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김기원 ( Ki Won Kim ),정혜경 ( Hye Kyoung Chung ),이한민 ( Han Min Lee ),조아라 ( A Ra Cho ),이세환 ( Se Whan Lee ),나성수 ( Seong Su Nah ),모상일 ( Sang Il Mo ),이혁규 ( Hyeok Gyu Lee ),고규봉 ( Gyu Bong Ko ),강병일 ( Byong Il Ka 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.1
Klinefelter`s syndrome (KFS) is a gonosomal aberration disease that occurs in males, and is characterized by 47, XXY karyotype, hypogonadism and a lack of secondary sexual characteristics. A potential link between this hormonally deficient syndrome and autoimmune disease, particularly systemic lupus erythematosus (SLE), has been reported. On the other hand, KFS is rarely reported to be accompanied by rheumatoid arthritis (RA), and there are no Korean cases reported. We report the first Korean case of a KFS patient with sero-positive RA and discuss the role of the pathogenesis of RA with KFS.