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Histological activity & ALT as predictors of HBeAg loss in lamivudine tx for chronic hepatititis B
강경희 ( Kang Gyeong Hui ),김세환 ( Kim Se Hwan ),박지현 ( Park Ji Hyeon ),이종협 ( Lee Jong Hyeob ),박창근 ( Park Chang Geun ),김성국 ( Kim Seong Gug ),최용환 ( Choe Yong Hwan ),권영오 ( Kwon Yeong O ),배한익 ( Bae Han Ig ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<배경 및 목적> 만성 B형 간염에서 Interferon 치료의 경우 반응을 예측할 수 있는 인자들로서는 상승된 ALT수치, 낮은 HBV DNA수치, 최근 감염, 야생형 등이 잘 알려져 있으나, 현재 만성 B형 간염의 치료에 많이 사용하는 Lamivudine의 경우 1년 치료시 약 15~30%의 내성 발현율을 보이고 있어 치료반응을 예측할 수 있는 인자를 통해 적절한 치료대상자를 선택하는 것이 중요한 문제이나 아직까지 그러한 인자들에 대한 연구결과들은
한국인에서 XPC 유전자의 다형성과 원발성 폐암의 위험도
김경록 ( Kim Gyeong Log ),이수연 ( Lee Su Yeon ),최진은 ( Choe Jin Eun ),김경미 ( Kim Gyeong Mi ),장상수 ( Jang Sang Su ),정치영 ( Jeong Chi Yeong ),강경희 ( Kang Gyeong Hui ),전경녀 ( Jeon Gyeong Nyeo ),차승익 ( Cha Seung Ig ) 대한결핵 및 호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.53 No.2
임상적으로 간경변증의 증후가 없는 만성 B형 간염에서 간섬유화의 지표로서 AST/ALT 비와 혈소판 수치의 임상적 유용성
박수영 ( Park Su Yeong ),강경희 ( Kang Gyeong Hui ),박지현 ( Park Ji Hyeon ),이종협 ( Lee Jong Hyeob ),조창민 ( Jo Chang Min ),탁원영 ( Tag Won Yeong ),권영오 ( Kwon Yeong O ),김성국 ( Kim Seong Gug ),최용환 ( Choe Yong Hwan ) 대한소화기학회 2004 대한소화기학회지 Vol.43 No.4
Background/Aims: Hepatic fibrosis is an important prognostic factor in chronic hepatitis B. Liver biopsy is a gold standard diagnostic tool but an invasive procedure, so it cannot be done on all patients. We evaluated the clinical efficacy of AST/ALT ratio and platelet counts as predictors of fibrosis in chronic hepatitis B. Methods: We reviewed retrospectively clinical records of 323 patients, who visited Kyungpook National University Hospital for chronic hepatitis B and underwent liver biopsy from September 1998 to May 2002. Correlation with laboratory parameters with hepatic fibrosis stage was identified. Results: Of 323 patients, there were 278 male patients with mean age 27 (9~59). Platelet counts showed a significant correlation (r=-0.343, p=0.000), and AST/ALT ratio showed a weak but significant correlation (r=0.137, p=0.013) with fibrosis stage. Patients with severe fibrosis or cirrhosis (stage 3 and 4) can be identified to have AST/ALT ratio >1 and platelet counts <150,000/mm3, which showed with positive predictive value of 66.7%. Sensitivity, specificity, and negative predictive value were 14.6%, 97.5%, and 77.0%, respectively. Conclusions: In chronic hepatitis B patients without clinical evidence of cirrhosis, severe hepatic fibrosis might be predicted using laboratory parameters of AST/ALT>1 in combination with platelet counts. However, its sensitivity is too low to replace liver biopsy. (Korean J Gastroenterol 2004;43:246-251)
한국인에서 hOGG1 유전자의 Ser326Cys 다형성과 원발성 폐암의 위험도
채상철 ( Chae Sang Cheol ),김경록 ( Kim Gyeong Log ),주소영 ( Ju So Yeong ),이수연 ( Lee Su Yeon ),강경희 ( Kang Gyeong Hui ),전경녀 ( Jeon Gyeong Nyeo ),차승익 ( Cha Seung Ig ),김창호 ( Kim Chang Ho ),정태훈 ( Jeong Tae Hun ) 대한결핵 및 호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.52 No.1
한국인 남성에서 GSTM1과 CYP1A1 유전자 다형성과 원발성폐암의 유전적 감수성
배낙천 ( Bae Nag Cheon ),이수연 ( Lee Su Yeon ),채포희 ( Chae Po Hui ),강경희 ( Kang Gyeong Hui ),김경록 ( Kim Gyeong Log ),차승익 ( Cha Seung Ig ),채상철 ( Chae Sang Cheol ),김창호 ( Kim Chang Ho ),정태훈 ( Jeong Tae Hun ),박재용 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.50 No.5
재배중심 원예치료가 감정표현불능증 정도에 따른 만성정신분열병 환자들의 대인관계변화와 자존감 및 기분에 미치는 영향
송미혜(Mi Hye Song),박철수(Chul Soo Park),강경희(Gyeong Hui Kang),이선숙(Sun Sook Lee),허무룡(Moo Ryong Huh) 인간식물환경학회 2015 인간식물환경학회지 Vol.18 No.2
The objective of this study was to feasibility search about horticultural therapy program focusing on cultivation with emotion promotion program for chronic schizophrenic patients according to alexithymia levels by analyzing effect on personal relationship, self-esteem and mood. This study was conducted once a week from March 26th, 2014 to June 11th, 2014 at health center in Haman for 10 chronic schizophrenic patients. Only heavy alexithymia group had significant decline about factor 1 (difficulty identifying feelings: F1) and factor 2 (difficulty describing feelings: F2) in TAS-20K after horticultural therapy program focusing on cultivation. And confidence, openness, and understanding scores in relationship respectively increased significant (1.4 score, 5 score, 5.4 score). In addition self-esteem increased significant score in heavy and none-heavy alexithymia group without reference to alexithymia. On the other hand, mood had not significant to both. This result showed a possibility of horticultural therapy program focusing on cultivation for chronic schizophrenic patients according to alexithymia levels as therapeutic tool.
건강검진 수진자에서 ALT치의 증가와 비만 관련인자들과 상관관계
이종협 ( Lee Jong Hyeob ),김세환 ( Kim Se Hwan ),박지현 ( Park Ji Hyeon ),강경희 ( Kang Gyeong Hui ),권영오 ( Kwon Yeong O ),조창민 ( Jo Chang Min ),김성국 ( Kim Seong Gug ),최용환 ( Choe Yong Hwan ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<배경> 원인이 뚜렷하지 않은 경우 과체중이나 비만이 간질환과의 관련성이 있다고 알려져 있다. 비알코올성 지방관질환(NAFLD)은 단순한 지방증에서부터 지방간염, 간경변 심지어 간부전까지를 포함하며 비만이 지방간만을 유발하는 것이 아니라 염증소견을 동반하면서 섬유화를 일으키며 간경변증으로 진행이 가능하며 또한 간암까지 합병될 수 있다는 점에서 중요하다. 물론 모든 NAFLD 환자들이 비만한 것은 아니지만 비만이 가장 중요한 위험인자로 여겨지고 있다. 비
농촌지역 주민들에서 만성 의학적 질환이 자살사고에 미치는 영향
장지훈(Jihoon Jang),차보석(Boseok Cha),이동윤(Dongyun Lee),강경희(Gyeong Hui Kang),이선숙(Sun Sook Lee),홍미향(Mi Hyang Hong),강미옥(Mi Ok Kang),김봉조(Bong-Jo Kim),이철순(Cheol-Soon Lee),이소진(So-Jin Lee),서지영(Jiyeong Seo),안인영(In 대한생물치료정신의학회 2016 생물치료정신의학 Vol.22 No.3
Objectives:This study attempted to investigate the effects of chronic medical diseases on suicidal ideation in a rural population, focusing on differences between adults and elderly individuals. Methods:We conducted a community-based, cross-sectional study on 682 subjects residing in rural areas. Participants aged 18–79 years were interviewed at home to assess the presence of current or past chronic medical diseases(lifetime). All participants completed the Center for Epidemiologic Studies Depression scale, Beck Scale for Suicide Ideation, Beck Anxiety Inventory, Alcohol Use Disorder Identification Test, and Barratt Impulsiveness Scale-11. Multiple logistic regression analysis was conducted to analyze the influences of chronic medical diseases on suicidal ideation in the “adult group” and “elderly group.” Results:In the unadjusted model, cardiovascular diseases(odds ratio : OR, 11.86; 95% confidence interval : 95% CI, 3.07-45.83), arthritis(OR, 3.72; 95% CI, 1.55-8.95), and cerebrovascular diseases(OR, 9.47 : 95% CI, 2.64-34.00) were significantly associated with increased suicidal ideation among adults. Furthermore, the association between cardiovascular diseases and increased suicidal ideation remained significant(OR, 12.53 : 95% CI, 1.51-104.17) after adjusting for sociodemographic factors, depression, anxiety, impulsivity, and problematic alcohol use. In elderly group, arthritis was the only significant risk factor for increased suicidal ideation in both unadjusted and adjusted models(OR, 2.80; 95% CI, 1.13-6.94 and OR, 3.71; 95% CI, 1.05-13.08, respectively). Conclusion:Chronic medical diseases that were associated with suicidal ideation differed by age group. This study suggests that primary-care physicians need to carefully assess suicidal ideation in adult patients with cardiovascular diseases and elderly patients with arthritis.
안인영(In-Young Ahn),서지영(Ji-Yeong Seo),이동윤(Dongyun Lee),이철순(Cheol-Soon Lee),최재원(Jae-Won Choi),이소진(So-Jin Lee),차보석(Boseok Cha),김봉조(Bong-Jo Kim),강경희(Gyeong Hui Kang),이선숙(Sun Sook Lee),홍미향(Mi Hyang Hong),조재 대한생물치료정신의학회 2017 생물치료정신의학 Vol.23 No.3
Objectives:The aim of this study was to examine the severity of family relations risk and depressive symptom of marriage immigrant women and investigate risk factors which influence family relations risk. Methods:All participants conducted self-report questionnaire survey including sociodemographic characteristics, Family Relations Problem Symptoms Scale, Patient Health Questionnaire-9(PHQ-9). Spearman correlation analysis was performed to examine the relationship between depressive symptoms and family relations problem symptoms. Also, logistic regression analysis was conducted to identify the risk factors which influence the family relations risk. Results:A total of 350 participants were enrolled in this study. There was a significant positive correlation between depressive symptom score and Family Relations Problem Symptoms Scale score(r=0.33, p<0.01). Obtaining Korean nationality(O.R=3.23, 95% CI=1.04-10.01) and depression(O.R=11.32, 95% CI=1.73-74.21) were significant predictors for increased family relations risk in marriage immigrant women. Conclusion:This study emphasizes the need for institutional support including acquisition of nationality and active management of depressive symptoms to help marriage immigrant women settle in domestic society.