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Bo Liu,Mahdi Jasim M,Rahbari Alireza,Majdi Hasan Sh,Xin Yi,Yaïci Wahiba,Talebizadehsardari Pouyan 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.6
Phase change material (PCM) is considered as one of the most effective thermal energy storage (TES) systems to balance energy supply and demand. A key challenge in designing efficient PCM-based TES systems lies in the enhancement of heat transmission during phase transition. This study numerically examines the privilege of employing twisted-fin arrays inside a shell-and-tube latent heat storage unit to improve the solidification performance. The presence of twisted fins contributes to the dominating role of heat conduction by their curved shapes, which restricts the role of natural convection but largely aids the overall heat-transfer process during solidification. The heat-discharge rate of twisted-fin configuration is increased by ∼14 and ∼55% compared to straight fin and no fin configurations—leading to a reduction in the solidification duration by ∼13 and ∼35%, respectively. The solidification front at various times has also been assessed through a detailed parametric study over the fin height, fin pitch number, and fin thickness. Over the range of values assumed, the fin height is the most dominant parameter – increasing the heat-retrieval rate from 10.0 to 11.4 W and decreasing the discharge time from above 3600 to 2880 s by varying the fin height from 2.5 to 7.5 mm.
Liu, Li-Ya,Yu, Hao,Bai, Jian-Ling,Zeng, Ping,Miao, Dan-Dan,Chen, Feng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3
Background: With development and application of new and effective anti-cancer drugs, the median survival post-progression (SPP) is often prolonged, and the role of the median SPP on surrogacy performance should be considered. To evaluate the impact of the median SPP on the correlation between progression-free survival (PFS) and overall survival (OS), we performed simulations for treatment of four types of cancer, advanced gastric cancer (AGC), metastatic colorectal cancer (MCC), glioblastoma (GBM), and advanced non-small-cell lung cancer (ANSCLC). Materials and Methods: The effects of the median SPP on the statistical properties of OS and the correlation between PFS and OS were assessed. Further, comparisons were made between the surrogacy performance based on real data from meta-analyses and simulation results with similar scenarios. Results: The probability of a significant gain in OS and HR for OS was decreased by an increase of the SPP/OS ratio or by a decrease of observed treatment benefit for PFS. Similarly, for each of the four types of cancer, the correlation between PFS and OS was reduced as the median SPP increased from 2 to 12 months. Except for ANSCLC, for which the median SPP was equal to the true value, the simulated correlation between PFS and OS was consistent with the values derived from meta-analyses for the other three kinds of cancer. Further, for these three types of cancer, when the median SPP was controlled at a designated level (i.e., < 4 months for AGC, < 12 months for MCC, and <6 months for GBM), the correlation between PFS and OS was strong; and the power of OS reached 34.9% at the minimum. Conclusions: PFS is an acceptable surrogate endpoint for OS under the condition of controlling SPPs for AGC, MCC, and GBM at their limit levels; a similar conclusion cannot be made for ANSCLC.
Liu, Ya-Qi,Park, Nam Sook,Kim, Yong Gyun,Kim, Keun Ki,Park, Hyun Chul,Son, Hong Joo,Hong, Chang Ho,Lee, Sang Mong Korean Society of Sericultural Science 2014 International Journal of Industrial Entomology Vol.28 No.2
The full-length heat shock protein 88 (HSP88) complementary DNA (cDNA) of Paecilomyces tenuipes Jocheon-1 was obtained by screening the Paecilomyces tenuipes (P. tenuipes) Jocheon-1 Uni-Zap cDNA library and performing 5' RACE polymerase chain reaction (PCR). The P. tenuipes Jocheon-1 HSP88 cDNA contained an open reading frame (ORF) of 2,139-basepair encoding 713 amino acid residues. The deduced amino acid sequence of the P. tenuipe s Jocheon-1 HSP88 cDNA showed 77% identity to Nectria haematococca HSP88 and 45-76% identity to other fungal homologous HSP88s. Phylogenetic analysis and BLAST program analysis confirmed that the deduced amino acid sequences of the P. tenuipes Jocheon-1 HSP88 gene belonged to the ascomycetes group within the fungal clade. The P. tenuipes Jocheon-1 HSP88 also contained the conserved ATPase domain at the N-terminal region. The cDNA encoding P. tenuipes Jocheon-1 HSP88 was expressed as an 88 kilodalton (kDa) polypeptide in baculovirus-infected insect Sf9 cells. Under higher temperature conditions for the growth of the entomopathogenic fungus, mRNA expression of P. tenuipes Jocheon-1 HSP88 was quantified by real time PCR (qPCR). The results showed that heat shock stress induced a higher level of mRNA expression compared to normal growth conditions.
Liu, Yong-Qi,Li, Yi,Qin, Jie,Wang, Qian,She, Ya-Li,Luo, Ya-Li,He, Jian-Xin,Li, Jing-Ya,Xie, Xiao-Dong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Matrine, a main active component extracted from dry roots of Sophora flavecens, has been reported to exert antitumor effects on A549 human non-small lung cancer cells, but its mechanisms of action remain unclear. To determine effects of matrine on proliferation of A549 cells and assess possible mechanisms, MTT assays were employed to detect cytotoxicity, along with o flow cytometric analysis of DNA content of nuclei of cells following staining with propidium iodide to analyze cell cycle distribution. Western blotting was performed to determined expression levels of Bax, Bcl-2, VEGF and HDAC1, while a microarray was used to assessed changes of miRNA profiles. In the MTT assay, matrine suppressed growth of human lung cancer cell A549 in a dose- and timedependent manner at doses of 0.25-2.5 mg/ml for 24h, 48h or 72h. Matrine induced cell cycle arrest in G0/G1 phase and decreased the G2/M phase, while down-regulating the expression of Bcl2 protein, leading to a reduction in the Bcl-2/Bax ratio. In addition, matrine down regulated the expression level of VEGF and HDAC1 of A549 cells. Microarray analysis demonstrated that matrine altered the expression level of miRNAs compared with untreated control A549 cells. In conclusion, matrine could inhibit proliferation of A549 cells, providing useful information for understanding anticancer mechanisms.
UV-crosslinked Solution Blown PVDF Nanofiber Mats for Protective Applications
Ya Liu,Xueming Wang,Nana Li,Xiaoyin Wang,Lei Shi,Enjie Wu,Rui Wang,Mingjing Shan,Xupin Zhuang 한국섬유공학회 2020 Fibers and polymers Vol.21 No.3
Nanofiber mats have received considerable attention from researchers in the field of particulate protection. In thisstudy, polyvinylidene fluoride (PVDF) nanofiber mats were prepared on a large scale by a solution blowing process, and thencrosslinked by ultraviolet (UV)-radiation using trimethylolpropane tri-acrylate (TMPTA) as a crosslinker. The structure,morphology, mechanical and thermal properties, and protective performance of the nanofiber mats were evaluated. Resultsshow that the addition of TMPTA and UV treatment decreased the diameter of the nanofibers and enhanced the mechanicalproperties, air permeability, and moisture permeability. Nanofiber mats show higher filtration and lower filtration resistancecompared with a commercial product. Furthermore, the nanofiber mats were bonded with Nylon 6 fabric, which showedgood performance as a novel functional layer in protective clothing.
New Analysis of Reduced-Version of Piccolo in the Single-Key Scenario
( Ya Liu ),( Liang Cheng ),( Fengyu Zhao ),( Chunhua Su ),( Zhiqiang Liu ),( Wei Li ),( Dawu Gu ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.9
The lightweight block cipher Piccolo adopts Generalized Feistel Network structure with 64 bits of block size. Its key supports 80 bits or 128 bits, expressed by Piccolo-80 or Piccolo-128, respectively. In this paper, we exploit the security of reduced version of Piccolo from the first round with the pre-whitening layer, which shows the vulnerability of original Piccolo. As a matter of fact, we first study some linear relations among the round subkeys and the properties of linear layer. Based on them, we evaluate the security of Piccolo-80/128 against the meet-in-the-middle attack. Finally, we attack 13 rounds of Piccolo-80 by applying a 5-round distinguisher, which requires 2<sup>44</sup> chosen plaintexts, 2<sup>67.39</sup> encryptions and 2<sup>64.91</sup> blocks, respectively. Moreover, we also attack 17 rounds of Piccolo-128 by using a 7-round distinguisher, which requires 2<sup>44</sup> chosen plaintexts, 2<sup>126</sup> encryptions and 2<sup>125.49</sup> blocks, respectively. Compared with the previous cryptanalytic results, our results are the currently best ones if considering Piccolo from the first round with the pre-whitening layer.