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      • 複制中國書畵文物的歷史和現狀及複制工藝技術

        曹靜樓,郭文林 용인대학교 박물관 2003 丹豪文化硏究 Vol.- No.7

        Imno(臨摹 copying) of the painting and writing in China is combined result of many closely-related elements that include Chinese cultural tradition and philosophy and substantial characteristics of Chinese paintings and calligraphy. ① Chinese rulers throughout history, under the so-called theory of 'Sungkyohuajoinlon' (成敎化助人論 to help people by educating them) often relied on paintings as a means to strengthen their governing foundation while using them to educate their subjects and people. For example, Hyojaeuisudo ≪孝子義士圖, a painting of devoted children and righteous people≫ meant the loyalty and obedience, Yulyujun ≪烈女傳, a story of virtuous women≫ was used to signify the importance of chastity in a feudal society. Paintings with such themes were met with the rulers ethics and, with the supports from the rulers, used as a means to publicize their ethics and educate their subjects and people. ② There were many rulers who were good at or loved the writing and painting in ancient China. Among many, Taizhong Li Shimin at Tang Dynasty(唐 太宗 李世民), Xianzhong Li Jiangji(玄宗 李降基), Huizhong Jo Ji at Song Dynasty (宋代 徽宗 趙佶), Xunzhong Zhu Jianshen at Ming Dynasty(明代 憲宗 朱見深), Gaozhong Hong Li at Qing Dynasty(靑代 高宗 弘力) are such examples. Development of painting and writing arts in China was achieved with the interests of rulers in them, and important eras that marked the history of Chinese painting and writing arts were created. Until the year of Huizhong(徽宗), the level of painting and writing was an important condition in deciding a governmental position. However, in ancient times, since there was a limited number of painting and writing works and lack of printing technology, emperors and high officials of literature had to be satisfied only with enjoying them and hoped to possess them. In the government, a special bureau was established to educate and raise the professionals who could duplicate the paintings and writings. This tendency influenced the society as a whole, and the atmosphere of reproduction of painting and writing works by duplication gradually culminated. ③ Chinese philosophy had also influenced their painting and writing arts. Chinese drawings pursue objectivity and has an expression style of Chuninhapil (天人合一, heaven and human beings are one). In Chinese drawings, artists describe the natural object and at the same time transfer their mind and feelings in them. Nature in the drawings is not just the nature as it is seen, but it is the nature observed and attained by artists and drawn from deep inside of artists. When people learn Chinese drawings for the first time, they are not taught how to describe the forms as in the western style but receive formative train in that people enter into the nature and sketch. This is the reason why artists, when copying the works in the past, are able to obtain the feelings of nature and learn various brush techniques that are applied in Chinese drawings. Therefore, copying is a significant method to learn Chinese drawings. For example, SunMyo(線描 line description) has a certain form, and a famous ShipPalMyo (十八描 18 descriptions) including ChulSunMyo(鐵線描), YuSaMyo (遊絲描), NanYupMyo (蘭葉描), YuYupMyo (柳葉描), JoEuiMyo (曹衣描) was created. Since these lines don't exist in natural objects, it is impossible to learn them through sketching. They can be learned only by copying the works in the past, in which they equates with various drawing styles that are applied when painting various objects. For example, JunBup(준法 technique to express the feel of the surface as it is) used for landscape drawings is helpful when expressing the touch and feelings of various rocks. For example, BuByukJun(斧劈준) or WooJumJun(雨點준) are good for expressing the characteristics of Chinese northern landscape, PiMaJun(披痲준) or MiJumJun(米點준) for Chinese southern landscape. This JunBup does not exist in natural objects such as mountain or rock, and artists can learn the right JunBup for various rocks through copying the works of the past. ④ Traditional thinking that stresses the relationship between a teacher and disciple in Chinese culture had also influenced Chinese painting and writing arts. When people beging to learn Chinese drawings, they must copy the works of their teacher. Therefore, when other people look at the drawings, they know who is with which teacher and which school. The drawings of certain artists are used as an educational purpose when students learn drawings for copying. For example, SaSaengJinBuDo ≪寫生珍禽圖≫ by Huang Jun (黃筌) in Song Dynasty was inherited to his son and learned as a work for copying. Each word in Immo(臨摹), according to the explanation in the ancient literature, has a separate meaning, Mo(摹 to copy) means Tap(榻 to copy), and Im(臨 to overlook) means Sa(寫 to write). Current meaning of Im(臨) is, while looking at the original drawing, to understand deeply and in details. When doing it, not only the techniques of brush, ink, and color but also the compositional characteristics should be thoroughly studied in order to completely familiarize with the form and line of the original drawing. And then, it has to be reproduced on another paper in one moment, and the copy does not have to be and can not be exactly the same as the original. Im(臨), based upon the complete understanding of the original, is to complete the copy with one energy without looking at the original. Mo(摹) is, while placing a thin paper right over the ancient drawing book, to copy both thick and thin lines, and Mo(摹)'s meaning in copying of a painting (摹畵) is the same. In ancient times, Mo(摹) was replaced with Mo(模 to imitate) or Mu(撫 to stroke). In other words, a transparent paper is placed over the original, the first copy is accurately made, the original is removed, drawing paper is placed over the first copy, and drawing is done in details while referring the original. Two words, Im(臨) and Mo(摹), originally impose a separate meaning and cant be one word, but they are habitually used as one word. Mo(摹) used in current China cant be Im (臨) but has to be called as Motap (摹榻). Especially, copying and counterfeiting are fundamentally different and can't be used as same meaning. The purpose of copying is a complete reproduction of energy and form of the original, and it is to conserve and actively publicize the original. The purpose of counterfeiting is to gain profits while falsely stating someone else's name as his or her own, and it includes the meaning of damaging the original. They also have difference in using the technique. The work of copying is faithful to the original and completely reproduce the smallest detail. People producing the copies must perfectly understand the spirit and form of the original, and successful copies should contain both the form and spirit. Rather, counterfeit is not based on the original but freely drawn upon studying a certain brush style of ones own. As a result, artists of counterfeit who are very well aware of the brush style used by the original artist are famous artists and might be the person who lives the same period with or the disciple of the original artist. Paintings produced for the purpose of counterfeiting possibly be the fraud and trouble to judge the authenticity of the work in a later period. Copying project of painting and writing at the Palace Museum is to replace the original work with the copied one by the time of difficulty in exhibiting the original, which is the best way to conserve the original. Copying of ancient paintings and calligraphy does not only mean the line description, outlining, coloring), or usage of ink. It is a very difficult process of re-creation that requires sincerity and efforts. Since the Palace Museum has started the copying project in 1950s, top artists are putting their efforts to copy and duplicate highly-valuable cultural artifacts. They have copied famous drawings of Qin, Tang, Song and Yuan dynasty with strict working attitude and exquisite techniques. Famous Chungmyungsanghudo≪淸明上河圖≫, Hanheejaeyayeondo ≪韓熙載夜宴圖≫, Guasukpyungwondo≪과石平遠圖≫ by Kwak Hee(郭熙), and Chunggeumdo ≪聽琴圖≫ by Jo Gil (趙佶) are such examples. Not many professionals are working for the copies in China. There were few in the Shanghai(上海) and Nanjing(南京) Museum during 1980s, but they are no longer there with various reasons. In Dunhuang(敦煌) and Xian (西安), frescoes are mainly being replicated. The quality of professionals who work to copy at the Palace Museum are the best in its technique and size and cannot be compared to other museums. Copying one painting successfully requires a lot of preparations. When producing the copies, it takes from few days to several years. Thus, safety of the original should be guaranteed, and there should not be done even a small damage. But observing the original should be convenient, and copying process should be progressed with many attentions.

      • BRCA1 Gene Exon 11 Mutations in Uighur and Han Women with Early-onset Sporadic Breast Cancer in the Northwest Region of China

        Cao, Yu-Wen,Fu, Xin-Ge,Wan, Guo-Xing,Yu, Shi-Ying,Cui, Xiao-Bin,Li, Li,Jiang, Jin-Fang,Zheng, Yu-Qin,Zhang, Wen-Jie,Li, Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

        The prevalence of BRCA1 gene mutations in breast cancer differs between diverse ethnic groups. Relatively little information is known about patterns of BRCA1 mutations in early-onset breast cancer in women of Uighur or Han descent, the major ethnic populations of the Xinjiang region in China. The aim of this study was to identify BRCA1 mutations in Uighur and Han patients with early-onset (age <35 years), and sporadic breast cancer for genetic predisposition to breast cancer. For detection of BRCA1 mutations, we used a polymerase chain reaction single-stranded conformation polymorphism approach, followed by direct DNA sequencing in 22 Uighur and 13 Han women with early-onset sporadic breast cancer, and 32 women with benign breast diseases. The prevalence of BRCA1 mutations in this population was 22.9% (8/35) among early-onset sporadic breast cancer cases. Of these, 31.8% (7/22) of Uighur patients and 7.69% (1/13) of Han patients were found to have BRCA1 mutations. In 7 Uighur patients with BRCA1 mutations, there were 11 unique sequence alterations in the BRCA1 gene, including 4 clearly disease-associated mutations on exon 11 and 3 variants of uncertain clinical significance on exon 11, meanwhile 4 neutral variants on intron 20 or 2. None of the 11 BRCA1 mutations identified have been previously reported in the Breast Cancer Information Core database. These findings reflect the prevalence of BRCA1 mutations in Uighur women with early-onset and sporadic breast cancer, which will allow for provision of appropriate genetic counseling and treatment for Uighur patients in the Xinjiang region.

      • SCIESCOPUSKCI등재

        Sensing behavior of Cu‑embedded C3N monolayer upon dissolved gases in transformer oil: a first‑principles study

        Wen Cao,Chunmei Liu,Pengfei Jia,Hao Cui 한국탄소학회 2021 Carbon Letters Vol.31 No.3

        Using first-principles theory, this work investigated the Cu-doping behavior on the N-vacancy of the C3N monolayer and simulated the adsorption performance of Cu-doped C3N (Cu–C3N) monolayer upon two dissolved gases ( H2 and C2H2). The calculations meant to explore novel candidate for sensing application in the field of electrical engineering evaluating the operation status of the transformers. Our results indicated that the Cu dopant could be stably anchored on the N- vacancy with the Eb of ? 3.65 eV and caused a magnetic moment of 1 μB. The Cu–C3N monolayer has stronger performance upon C2H2 adsorption than H2 give the larger Ead, QT and change in electronic behavior. The frontier molecular orbital (FMO) theory indicates that Cu–C3N monolayer has the potential to be applied as a resistance-type sensor for detection of such two gases, while the work function analysis evidences its potential as a field-effect transistor sensor as well. Our work can bring beneficial information for exploration of novel sensing material to be applied in the field of electrical engineering, and provide guidance to explore novel nano-sensors in many fields.

      • SCIESCOPUSKCI등재

        Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in H22 tumor-bearing mice

        Cao, Wen,Mo, Kai,Wei, Sijun,Lan, Xiaobu,Zhang, Wenjuan,Jiang, Weizhe The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6

        Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species of Boraginaceae and Lamiaceae. The previous studies have revealed that RA had therapeutic effects on hepatocellular carcinoma (HCC) in the H22-xenograft models by inhibiting the inflammatory cytokines and $NF-{\kappa}B$ p65 pathway in the tumor microenvironment. However, its molecular mechanisms of immunoregulation and pro-apoptotic effect in HCC have not been fully explored. In the present study, RA at 75, 150, and 300 mg/kg was given to H22 tumor-bearing mice via gavage once a day for 10 days. The results showed that RA can effectively inhibit the tumor growth through regulating the ratio of $CD4^+/CD8^+$ and the secretion of interleukin (IL)-2 and interferon-${\gamma}$, inhibiting the expressions of IL-6, IL-10 and signal transducer and activator of transcription 3, thereby up-regulating Bax and Caspase-3 and down-regulating Bcl-2. The underlying mechanisms involved regulation of immune response and induction of HCC cell apoptosis. These results may provide a more comprehensive perspective to clarify the anti-tumor mechanism of RA in HCC.

      • KCI등재

        Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in H22 tumor-bearing mice

        Wen Cao,Kai Mo,Sijun Wei,Xiaobu Lan,Wenjuan Zhang,Weizhe Jiang 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6

        Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species of Boraginaceae and Lamiaceae. The previous studies have revealed that RA had therapeutic effects on hepatocellular carcinoma (HCC) in the H22-xenograft models by inhibiting the inflammatory cytokines and NF-κB p65 pathway in the tumor microenvironment. However, its molecular mechanisms of immunoregulation and pro-apoptotic effect in HCC have not been fully explored. In the present study, RA at 75, 150, and 300 mg/kg was given to H22 tumor-bearing mice via gavage once a day for 10 days. The results showed that RA can effectively inhibit the tumor growth through regulating the ratio of CD4+/CD8+ and the secretion of interleukin (IL)-2 and interferon-γ, inhibiting the expressions of IL-6, IL-10 and signal transducer and activator of transcription 3, thereby up-regulating Bax and Caspase-3 and down-regulating Bcl-2 . The underlying mechanisms involved regulation of immune response and induction of HCC cell apoptosis. These results may provide a more comprehensive perspective to clarify the anti-tumor mechanism of RA in HCC.

      • KCI등재
      • Associations Between TLR9 Polymorphisms and Cancer Risk: Evidence from an Updated Meta-analysis of 25,685 Subjects

        Wan, Guo-Xing,Cao, Yu-Wen,Li, Wen-Qin,Li, Yu-Cong,Zhang, Wen-Jie,Li, Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

        A meta-analysis incorporating 34 case-control studies from 19 articles involving 12,197 cases and 13,488 controls was conducted to assess the effects of three genetic variants of Toll-like receptor 9 (TLR9): rs187084, rs352140, and rs5743836. Studies on associations between TLR9 polymorphisms and cancer risk were systematically searched in electronic databases. The reported odds ratios (OR) and 95% confidence intervals (CI) were pooled to assess the strength of any associations. The results showed that the rs187084 polymorphism was significantly associated with an increased risk of cancer (CC vs TC+TT: OR=1.14, 95% CI=1.02-1.28), specifically cervical cancer (C vs T: OR=1.19, 95% CI=1.05-1.34; TC vs TT: OR=1.32, 95% CI=1.10-1.58; CC vs TT: OR=1.31, 95% CI=1.03-1.68; CC+TC vs TT: OR=1.32, 95% CI=1.11-1.56), and that this association was significantly positive in Caucasians (CC vs. TC+TT: OR=1.18, 95% CI=1.01-1.38). The rs352140 polymorphism had a protective effect on breast cancer (GA vs GG: OR=0.77, 95% CI=0.66-0.89), whereas the rs5743836 polymorphism was likely protective for digestive system cancers (CC+TC vs TT: OR=0.81, 95% CI=0.66-0.98). In conclusion, our results suggest that the rs187084 polymorphism may be associated with an elevated cancer risk, whereas polymorphisms of rs352140 and rs5743836 may play protective roles in the development of breast and digestive system cancers, respectively. From the results of this meta-analysis further large-scale case-control studies are warranted to verify associations between TLR9 polymorphisms and cancer.

      • SCIESCOPUSKCI등재

        A Trellis-based Technique for Blind Channel Estimation and Equalization

        Cao, Lei,Chen, Chang-Wen,Orlik, Philip,Zhang, Jinyun,Gu, Daqing The Korea Institute of Information and Commucation 2004 Journal of communications and networks Vol.6 No.1

        In this paper, we present a trellis-based blind channel estimation and equalization technique coupling two kinds of adaptive Viterbi algorithms. First, the initial blind channel estimation is accomplished by incorporating the list parallel Viterbi algorithm with the least mean square (LMS) updating approach. In this operation, multiple trellis mappings are preserved simultaneously and ranked in terms of path metrics. Equivalently, multiple channel estimates are maintained and updated once a single symbol is received. Second, the best channel estimate from the above operation will be adopted to set up the whole trellis. The conventional adaptive Viterbi algorithm is then applied to detect the signal and further update the channel estimate alternately. A small delay is introduced for the symbol detection and the decision feedback to smooth the noise impact. An automatic switch between the above two operations is also proposed by exploiting the evolution of path metrics and the linear constraint inherent in the trellis mapping. Simulation has shown an overall excellent performance of the proposed scheme in terms of mean square error (MSE) for channel estimation, robustness to the initial channel guess, computational complexity, and channel equalization.

      • SCIESCOPUSKCI등재

        Online monitoring of IGBT junction temperature based on V<sub>ce</sub> measurement

        Cao, Han,Ning, Puqi,Chai, Xiaoguang,Zheng, Dan,Kang, Yuhui,Wen, Xuhui The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.2

        In this paper, an online junction temperature monitoring method based on the on-state voltage under high collector current density measurements for IGBT power modules is proposed. Unlike the conventional junction temperature monitoring method, the presented method can extract the junction temperature during operation without altering the modulation strategy or topology of the converter. The proposed method is verified by simulations and the JEDEC-51 standard recommended approach. To accurately extract the on-state voltage during operation, a measurement circuit that combines the advantages of both the active MOSFET clamp and the diode clamp is designed and tested. It has been shown to have good accuracy and a rapid response time. After the calibration results are obtained, the presented method is applied to a three-phase voltage source converter controlled by a closed-loop SVPWM modulation strategy.

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