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Lee, Meesun,Lee, Sangmi,Jeong, Hohyn,Park, Manyong,Kim, Dong-Woung,Song, Bong-Keun,Lee, Jong-Deok,Lee, Ho Sub,Kim, Sungchul KOREAN PHARMACOPUNCTURE INSTITUTE 2013 Journal of pharmacopuncture Vol.16 No.1
Objective: The aim of this experiment was to investigate the effect and the mechanism of Geumgoeshingi-whan (GGSGW) Pharmacopuncture at the acupoint GV 4 on the blood pressure in spontaneously hypertensive rats (SHR). Methods: SHR were injected with normal saline solution (Control-SHR group)or GGSGW Pharmacopuncture (GGSGW-SHR group) at the acupoint GV 4. The systolic arterial blood pressure and renal parameters were measured for two weeks. Results: The systolic arterial blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR, followed by a significant rise in creatine clearance. The plasma levels of aldosterone were decreased significantly after GGSGW Pharmacopunctureas were the plasma levels of atrial natriuretic peptide (ANP). Conclusion: These results suggest that the blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR and that the depressor response of the blood pressure was related to decreases in the plasma levels of aldosterone and ANP.
Lee, Sukjun,Lim, Donghyun,Lee, Eunyoung,Lee, Nakyung,Lee, Hong-gun,Cechetto, Jonathan,Liuzzi, Michel,Freitas-Junior, Lucio H.,Song, Jin Sook,Bae, Myung Ae,Oh, Sangmi,Ayong, Lawrence,Park, Seung Bum American Chemical Society 2014 Journal of medicinal chemistry Vol.57 No.17
<P>New antimalarial agents that exhibit multistage activities against drug-resistant strains of malaria parasites represent good starting points for developing next-generation antimalarial therapies. To facilitate the progression of such agents into the development phase, we developed an image-based parasitological screening method for defining drug effects on different asexual life cycle stages of <I>Plasmodium falciparum</I>. High-throughput screening of a newly assembled diversity-oriented synthetic library using this approach led to the identification of carbohybrid-based 2-aminopyrimidine compounds with fast-acting growth inhibitory activities against three laboratory strains of multidrug-resistant <I>P. falciparum</I>. Our structure–activity relationship study led to the identification of two derivatives (<B>8aA</B> and <B>11aA</B>) as the most promising antimalarial candidates (mean EC<SUB>50</SUB> of 0.130 and 0.096 μM against all three <I>P. falciparum</I> strains, selectivity indices >600, microsomal stabilities >80%, and mouse malaria ED<SUB>50</SUB> values of 0.32 and 0.12 mg/kg/day, respectively), targeting all major blood stages of multidrug-resistant <I>P. falciparum</I> parasites.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2014/jmcmar.2014.57.issue-17/jm5009693/production/images/medium/jm-2014-009693_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm5009693'>ACS Electronic Supporting Info</A></P>
Factors Affecting Health Behaviors in Late School-aged Children from Multicultural Families
Lee, Sangmi Korean Academy of Child Health Nursing 2020 Child Health Nursing Research Vol.26 No.1
Purpose: This study was conducted to investigate factors affecting health behaviors in late school-aged children from multicultural families. Methods: This study included 401 children (112 from multicultural families and 289 from non-multicultural backgrounds) in grades 4~6 in 11 elementary schools. Data on health behaviors and related factors (school adjustment, the mother-child relationship, self-efficacy, etc.) were collected from the children using self-reported questionnaires between May and June in 2019. The collected data were analyzed through a univariate analysis and multiple regression analysis. Results: The health behavior score of multicultural children was lower than that of non-multicultural children (t=3.32, p=.001). In multicultural children, school adjustment (β=.55, p<.001), mother-child relationship (β=.25, p=.001), and perceived health status (very healthy=1; β=.19, p=.011) were significant factors affecting their health behavior and explained 47.0% (F=30.93, p<.001) of the variance. Conclusion: Multicultural late school-aged children are at risk to engage in a lower level of health behaviors than their non-multicultural counterparts. More attention should be paid to ways of improving multicultural children's perceptions of their health status, maternal relationships, and school adjustment in order to promote health behaviors.
A New Method for Preparing Slide Mounts of Whole Bodies of Microlepidoptera
Sangmi Lee,Richard L. Brown 한국응용곤충학회 2006 Journal of Asia-Pacific Entomology Vol.9 No.3
A new method is described for preparing slide mounts of whole bodies of microlepidoptera to facilitate comparative morphological studies. This method conserves traditional characters of wing pattern while revealing wing venation and other morphological structures of the denuded body. Examples of new characters revealed on slide mounts of whole bodies and photographed with a Confocal Laser Scanning Microscope are given for selected species of Gelechioidea. Also, the historical use of morphological characters for defining taxa of Lepidoptera is briefly reviewed.
Stability of Purified Bee Venom on the Treatment Temperature
Sangmi Han,Miran Cho,JoungMin Kim,Myeonglyeol Lee,Manyoung Lee,Inpyo Hong,Soonok Woo,Hasik Sim,Yongsu Choi 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
For the investigation of the stability of purified bee venom(PBV) during the treatment in the temperature range of 50℃ to 120℃ for 24 hours, respectively, melittin contents, antibacterial effects, and cell regenerations were investigated. The changes in the melittin contents of PBV were not significantly different by treatment temperature below 70℃ for 24 houes and 80℃ for 4 hours. However the melttin contents is great decline after 24 hours above 80℃ for 24 hours. Antibacterial effects is not change below 80℃ for 4 houes but significantly decrease above 80℃ for 24 hours. Cell regenerations of PBV on human dermal fibroblast decreased at 80℃ for 24 houes, showing a significant difference from the below 80℃ for 4 houes. Through the temperature stability of PBV results of this study, it was treated that the melittin contents, antibacterial effects and cell regeneration effects of PBV could be maintained above 80℃ for 4 hours.
Sangmi Han,JungMin Kim,Miran Cho,Myeonglyeol Lee,Manyoung Lee,Inpyo Hong,Soonok Woo,Hasik Sim,Yongsu Choi,Younhee Jo 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
Royal jelly (RJ) is exclusive food that is secreted from the hypopharyngeal and mandibular glands of worker honeybees, and it is well known to be a necessary for the growth of the queen honeybee Although fresh royal jelly have been demonstrated to enhance wound healing, the wound healing effects of water soluble royal jelly (WSRJ) have not been elucidated. We investigated whether WSRJ promotes the migration, attachment, and proliferation of human dermal fibroblasts (HDFs) during in vitro wound healing. HDFs were treated with 1-5ug/ml WSRJ and RJ for up to 24hr following wound formation. Cell migration was assessed by measuring recovery from wound margin, while cell attachment and proliferation were determined by MTT assay. By observing the numbers of cell attached, we confirmed that not only WSRJ but also RJ did not affect on the initial cell adhesion. WSRJ (5 ug/ml) enhanced cell migration rate approximately 84.3% in HDFs at 24hr, whereas RJ (5 ug/ml) increased cell migration rate 71.3% in HDFs at 24hr, which is similar to cell migration rate of WSRJ 1 ug/ml (73.7%). In cell proliferation assays, WSRJ induced an increase in the number of HDFs, compared with control and RJ. In conclusion, WSRJ promotes cell migration with increased cell proliferation in an in vitro wound healing model.
Anti-melanogenic effect of Water Soluble Royal Jelly on Melanin Biosynthesis
Sangmi Han,Jungmin Kim,Miran Jo,Myeonglyeol Lee,Manyoung Lee,Inpyo Hong,Soonok Woo,Hasik Sim,Yongsoo Choi 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
Royal jelly (RJ) is one of the most attractive functional foods that have been a commercial product, especially in dietetics and cosmetics in many countries. However, RJ has been evoked with dermatitis, acute asthma and anaphylaxis because of major RJ proteins. Therefore, to access water soluble royal jelly (WSRJ) that removed allergy-induced proteins as an effective whitening agent for cosmetics and potential external treatment for topical use, we investigated its ability to inhibit melanin biosynthesis. B16F1 cells were treated with 10 nM α-melanocyte-stimulating hormone (α -MSH) for 48hr, and then were treated with various doses of WSRJ for 36hr. WSRJ (1-10ug/ml) inhibited direct tyrosinase activity and cellular tyrosinase activity, which lead to the decrease of melanin synthesis in α-MSH stimulated B16F1 melanoma cells. In addition, we examined RT-PCR and Western blotting for melanogenesis-related genes such as tyrosinase, tyrosinase related protein 1 (TRP-1) and 2. WSRJ suppressed mRNA and protein expression of tyrosinase, tyrosinase related protein (TRP)-1 and TRP-2 in α-MSH stimulated B16F1 cells, and similar to positive control, arbutin. Our findings suggest that WSRJ induced the downregulation of melanogenesis by inhibiting tyrosinase, TRP-1 and 2 activations. It may serve as a new candidate in the new skin-whitening agents.
Sangmi Lee 한국응용곤충학회 2011 Journal of Asia-Pacific Entomology Vol.14 No.3
The eight species of Pseudotelphusa (Gelechiidae: Litini) are known to occur in North America. Three new species of the genus from North America are described and illustrated.