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Yoon, Hoi Soo,Im, Ho Joon,Moon, Hyung Nam,Lee, Jae Hee,Kim, Hee-Jin,Yoo, Keon Hee,Sung, Ki Woong,Koo, Hong Hoe,Kang, Hyung Jin,Shin, Hee Young,Ahn, Hyo Seop,Cho, Bin,Kim, Hack Ki,Lyu, Chuhl Joo,Lee, M Blackwell Publishing Ltd 2010 Pediatric transplantation Vol.14 No.6
<P>Yoon HS, Im HJ, Moon HN, Lee JH, Kim H-J, Yoo KH, Sung KW, Koo HH, Kang HJ, Shin HY, Ahn HS, Cho B, Kim HK, Lyu CJ, Lee MJ, Kook H, Hwang TJ, Seo JJ. The outcome of hematopoietic stem cell transplantation in Korean children with hemophagocytic lymphohistiocytosis.Pediatr Transplantation 2010: 14:735–740. © 2010 John Wiley & Sons A/S.</P><P>Abstract: </P><P>Chemoimmunotherapy-based treatments have improved the survival of patients with HLH, but outcomes of the patients are still unsatisfactory. We report here the outcome of Korean children with HLH who underwent HSCT, which was analyzed from the data of a nation-wide HLH registry. Retrospective nation-wide data recruitment for the pediatric HLH patients diagnosed between 1996 and 2008 was carried out by the Histiocytosis Working Party of the Korean Society of Hematology. Nineteen patients who received HSCT among the total of 148 enrolled children with HLH were analyzed for the transplant-related variables and events. The probability of five-yr survival after HSCT was 73.3% with a median follow-up of 57. Two months compared to 54.3% for the patients who were treated with chemoimmunotherapy only (p<I> </I>=<I> </I>0.05). The reasons for HSCT were active disease after eight wk of initial treatment (n = 9), relapsed disease (n = 5), and FHL (n = 5). Fourteen patients are currently alive without disease after HSCT, four patients died of treatment-related events (infection in two and graft failure in two) at early post-transplant period, and one patient died of relapse at one yr post transplantation. The survival of patients who were transplanted because of active disease after eight wk of initial treatment was worse compared to those patients who had inactive state at that time (60.6% vs. 100%, respectively, p<I> </I>=<I> </I>0.06). Of the four patients who received transplants using cord blood, three died of graft failure (n = 2) and relapse (n = 1). The five-yr probability of survival after HSCT according to the donor type was 85.7% for the MRDs (n = 6), 87.5% for the MUDs (n = 8), and 40% for the MMUDs (n = 5) (p<I> </I>=<I> </I>0.03). Other variables such as age, CNS involvement at the time of diagnosis, the etiology of HLH (familial or secondary), and the conditioning regimens had no influence on the five-yr OS of the HLH patients who underwent HSCT. HSCT improved the survival of the patients who had familial, relapsed, or severe and persistent SHLH in the Korean nation-wide HLH registry. Although numbers were small, these results are similar to other reports in the literature. The disease state after initial treatment, the stem cell source of the transplant, and the donor type were the important prognostic factors that affected the OS of the HLH patients who underwent HSCT.</P>
Retrovirus-Mediated Gene Transfer and Expression of EGFP in Chicken
Koo, Bon Chul,Kwon Mo Sun,Choi, Bok Ruyl,Lee, Hoon Tack,Choi, Ho-Jun,Kim, Jin-Hoi,Kim, Nam-Hyung,Jeon, Iksoo,Chang, Wonkyong,Kim, Teoan 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8
Here, we successfully demonstrate expression of the EGFP (enhanced green fluorescence protein) gene in chickens using replication-defective MLV (murine leukemia virus)-based retrovirus vectors encapsidated with VSV-G (vesicular stomatitis virus G glycoprotein). The recombinant retrovirus was injected beneath the blastoderm of non-incubated chicken embryos (stage X). After 12 days incubation, all of the eight living embryos assayed were found to express this vector-encoded EGFP gene, which was under the control of the RSV (Rous Sarcoma Virus) promoter, in diverse organ tissues, including head, beak, neck, wing, hock, tail, toes, heart, amnion, and yolk sac. Surprisingly, despite the presumed cytotoxicity of EGFP, some embryos hatched and survived and these had prominent green fluorescent spots, both in internal organs and externally.
KOMPSAT-2 Terminal for Polar Station (K2PS) Development by KARI
Koo, In-Hoi,Kang, Ji-Hoon,Bae, Hee-Jin,Ahn, Sang-Il The Korean Society of Remote Sensing 2008 大韓遠隔探査學會誌 Vol.24 No.5
Recently, KARI developed "KOMPSAT-2 Terminal for Polar Station" which is high performance system newly required for stimulating KOMPSAT-2 application. The KOMPSAT-2 Terminal for Polar Station consists of one receiving system and two processing systems. The receiving system has been installed at Svalbard Satellite Station located at Norwegian Svalbard island. and the two receiving systems have been installed at Kongsberg Satellite Service AS located at Tromso Norway and Spot Image SA located at Toulouse France respectively. In this paper overall items of KOMPSAT-2 Terminal for Polar Station, which includes requirements, designs and operation concepts, are to be addressed with the verification result on its performance.
Koo, Bon Chul,Kwon, Mo Sun,Choi, Bok Ryul,Kim, Jin-Hoi,Cho, Seong-Keun,Sohn, Sea Hwan,Cho, Eun Jung,Lee, Hoon Taek,Chang, Wonkyung,Jeon, Iksoo,Park, Jin-Ki,Park, Jae Bok,Kim, Teoan 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
The Moloney murine leukemia virus (MoMLV) -based retrovirus vector system has been used most often in gene transfer work, but has been known to cause silencing of the imported gene in transgenic animals. In the present study, using a MoMLV-based retrovirUs vector, we successfully generated a new transgenic chicken line expressing high levels of enhanced green fluorescent protein (eGFP). The level of eGFP expression was conserved after germline transmission and as much as 100μg of eGFP could be detected per 1 mg of tissue protein. DNA sequencing showed that the transgene had been integrated at chromosome 26 of the G₁and G₂generation transgenic chickens. Owing to the stable integration of the transgene, it is. now feasible to produce G₃generation of homozygous eGFP transgenic chickens that will provide 100% transgenic eggs. These results will help establish a useful transgenic chicken model system for studies of embryonic development and for efficient production of transgenic chickens as bioreactors.
Hip Fracture Management during the COVID-19 Pandemic in South Korea
Jin-Won Chung,Yong-Chan Ha,Mi-Kyung Lee,Jin-Hak Kim,Jung-Wee Park,Kyung-Hoi Koo 대한정형외과학회 2021 Clinics in Orthopedic Surgery Vol.13 No.4
Background: The purpose of this study was to introduce a screening system for coronavirus disease 2019 (COVID-19), to evaluate the overall orthopedic management in hip fracture patients during the COVID-19 pandemic in South Korea, and to compare the surgical results in hip fracture patients during the COVID-19 pandemic with those of the previous year. Methods: Hip fracture patients who visited emergency rooms were screened at the screening clinics before admission. The medical management was carried out with the medical staff wearing surgical masks, meticulous hand hygiene observed, and a minimum distance of 2 m between patients maintained. The demographics, operative parameters, and surgical results of patients treated during the pandemic were compared with those from the previous year. Results: From January 2020 to July 21, 2020, 119 patients with hip fractures (33 men and 86 women) were admitted to our institution for surgical treatment. Five patients showed symptoms of pneumonia, but no patient was positive for COVID-19. The mortality rate during the study period was 4.2%, and none of the patients died due to COVID-19. The interval between admission and surgery and the length of hospital stay were significantly shorter (p = 0.008, p = 0.002) and the proportion of spinal anesthesia was greater in hip fracture patients during the COVID-19 pandemic compared to those from the previous year (p = 0.011). Conclusions: The COVID-19 screening system for hip fracture patients has proven to be effective in preventing intrahospital spread of the disease. Hip fracture surgery performed during the COVID-19 pandemic has shown comparable results without any COVID-19 infection and COVID-19-related mortality.
이진민(Jin Min Lee),이민욱(Min Uk Lee),조수길(Su Kil Cho),구만회(Man Hoi Koo),김학인(Hak In Gimm),이태희(Tae Hee Lee) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.11
An open frame structure is fastened by bolt joints for strength and shock attenuation. Therefore the full finite element model of an open frame structure should be properly modeled including bolt joints for strength analysis of the frames and joint assemblies which are operated under multi-loading conditions such as driving, drop, inertia and torsional loads. Then the joints and frames must satisfy the specified allowable strength constraints. Because the full finite element model has a large number of elements to perform strength analysis, a detailed fine bolt analysis seems to be very expensive. Therefore bolts of the full finite element model are approximately modeled by constraints equations to constrain degree of freedoms between adjacent nodes. However, the constraints equation method can exaggerate stress results at the constrained nodes. Thus a detailed bolt analysis and a theoretical/experiential formula of bolts for a worst bolt joint are performed using reaction force applied both bolt and bolt joint. Finally, the results from the two methods are compared and discussed to verify the safety of the open frame structure.
자기공명영상으로 선택된 환자에서의 대퇴전자간 회전 내전 절골술을 이용한 대퇴골두 무혈성 괴사환자의 치료
양진원 ( Jin Won Yang ),구경회 ( Kyung Hoi Koo ),송해룡 ( Hae Ryong Song ),정순택 ( Soon Taek Jeong ),박형빈 ( Hyung Bin Park ),이승환 ( Seung Hwan Lee ),정운하 ( Oun Hwa Chung ),조세현 ( Se Hyun Cho ) 대한고관절학회 1998 Hip and Pelvis Vol.10 No.2
We used MR(magnetic resonance) image to formulate new selection criteria for the identification of suitable patients with femoral head osteonecrosis for transtrochanteric rotational varizational osteotomy. The selection criteria included: [1] an early post-collapse osteonecrotic hip(loss of congruity or crescent sign) without narrowing of joint space or acetabular involvement; [2] an age of less than 55 years and a painful hip; [3] an angle of more than 120 of intact portion of the femoral head on midsagittal MR image. Seventeen patients met predefined selection criteria and were treated with the osteotomy. The angle of rotation was determined preoperatively in midsagittal MR image. The osteotomy included 20 of intentional varization. Postoperative scintigraphy showed adequate perfusion of the femoral head. They were followed for a period of 36 to 67 months(mean, 50 months). Hip score by Merle dAubigne et al improved from a mean of 13.4 preoperatively to a mean of 17.6 at the latest follow- up. Collapse of the feporal head was arrested in all hips and no case required a total hip arthroplasty. Use of MR images(kstead of plain radiograph) in the patient selection and in the determination of rotational angle may improve the success rate of the transtrochanteric rotational varizational osteotomy.