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원통형 연소실에서 단발 분출화염의 온도분포에 관한 연구
김춘중,최태환 영남이공대학 산업기술연구소 2003 産業技術硏究 Vol.15 No.-
Many researches about the combustion process gas temperature and velocity in a constant volume combustion chamber have been conducted. The temperature and the distribution of velocity in the combustion chamber have a large influence in the combustion process. Temperature distribution and their histories of jet flame in a constant combustion chamber were measured by a laser rayleigh pyrometer , as a fundamental study of the combustion process in a spark ignition engine. It makes this study get the important data of temperature histories and flame state of jet flame.
급성골수백혈병에 대한 관해유도화학요법 후의 Granulocyte Colony-stimulating Factor의 효과
윤환중,최지영,전의건,길준영,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
Granulocyte colony-stimulating factor(G-CSF) have been shown to hasten the recovery of neutropenia following anti-cancer chemotherapy. There are controversial opinions on the use of G-CSF in acute myelogenous leukemia(AML) because clonogenic studies have shown that G-CSF stimulates leukemic colonies as well as granulocyte colonies. In this study, we evaluated the effectiveness and safety of recombinant human G-CSF after induction chemotherapy with DAV regimen(Ara-C 100mg/㎡ day 1-8, Doxorubicin 45mg/㎡ day 3-5, VP-16 100mg/㎡ day 6-8) in 9 patients with AML. G-CSF therapy(200 ㎍/㎡/day) was begun 2 days after the end of chemotherapy and continued for 10 days. 17 AML patients who recieved the same chemotherapy before the onset of this study were used as historical control. G-CSF shortened the duration of granulocytopenia (less than 500/㎣) significantly (13 vs 23 days, p<0.001), but it had no effect on platelet recovery. Although the incidence of febrile episodes was almost the same, the duration of febrile episodes was shorter in the group treated with G-CSF( 5 vs 12 days, p=0.03). There was no evidence that G-CSF accelerated the regrowth of leukemic cells and the complete remission rates between the 2 groups were not different. These results show that G-CSF accelerates the recovery of granulocytopenia and shortens the febrile days after chemotherpy in patients with AML, without affecting the regrowth of leukemic cells.
급성골수성백혈병 환자에서 DAV 병용화학요법 후의 장기생존율
김삼용,최지영,윤환중,전의건,길준영,조덕연 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
Background : Despite substantial progress, the treatment of acute myeloid leukemia(AML) has produced complete remission in 60-80% of patients receiving induction chemotherapy, and median remission duration is about 12 months and only 20% to 35% of patients undergoing consolidation chemotherapy achieve long-term disease-free survival(DFS). We evaluated the long-term outcome of AML patients treated with doxorubicin/Ara-C/VP-16(DAV) induction chemotherapy and consolidation/intensification therapy. Method : Induction therapy : From January 1986 to December 1991, twenty three patients with previously untreated acute myelogenous leukemia received a course of 45mg/㎡ doxorubicin daily intravenously for three consecutive days with Ara-C at 100mg/㎡ by continuous intravenous infusion for eight consecutive days and VP-16 at 100mg/㎡ daily intravenously for three consecutive days. A second course of treatment was started if leukemia persisted on 22 days after treatment. Post-remission therapy : Three to six cycles were given at three or four months interval with Ara-C/doxorubicin/VP-16 regimen or other therapy. Results : Twenty two pateints were evaluable and complete remission was achieved in 16 of 22(73%). Median duration of complete remission was 8 months. The relapse rate was 81% and 63% relapsed in first year. 4-year survival rate of patients entering complete remission(n=16) was 19% and median survival duration was 14.5 months. The postremission chemotherapy was the only significant prognostic factor influencing long term disease free survival. No significant correlation was observed between the probability of survival and age (40< or >40), sex, FAR subgroup, and leukocyte count at diagnosis. The median survival duration were 21 months and 12.5 months for patients who received, or not received postremission chemotherapy respectively(P=0.035). Conclusion : Our results show that DAV combination chemotherapy is a useful therapeutic regimen in remission induction and postremission chemotherapy offering survival advantage in patients with AML entering complete remission.
결핵 진단을 위한 검사 방법간의 효율성에 관한 비교 분석
이원재,최석철,정천환,성희경,김태운 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCINE 1999 Journal of biomedical laboratory sciences Vol.5 No.2
최근 다약제 내성균주의 출현과 후천성 면역결핍증으로 인한 결핵발병률의 증가는 전세계적으로 중요한 보건문제가 되었다. 따라서 보다 빠르고 신뢰할 만한 진단법은 결핵박멸을 위한 가장 중요한 필요조건 중의 하나일 것이다. 본 연구는 171명의 환자를 대상으로 폐결핵 진단의 전통적 방법들 (X-선,항산성 염색,배양)과 PCR법간의 진단적 가치와 효율성을 비교 검토하기 위해 시행하였다. 흉부 X-선 소견 및 검사 결과 그리고 다른 임상 소견들을 통해 결핵으로 확진된 예는 전체 171건의 검체 중 39예 (22.8%)였다. 이러한 확진을 근거로 할 때 각 검사별 민감도, 특이도, 효율성, 위양성률, 위음성률을 살펴 보면 흉부 X-선의 경우 각각 69.2%, 87.1%, 83.0%, 12.9%, 30.8%; 항산성 염색의 경우 79.9%, 95.5%, 91.8%, 4.6%, 20.5%; 배양의 경우 56.4%, 99.2%, 89.5%, 0.8%, 43.6%; PCR의 경우 82.1%, 96.2%, 93.0%, 3.8%, 17.9%였다. PCR의 경우 가장 높은 민감도 및 효율성과 가장 낮은 위음성률을 보였다. 배양법은 가장 높은 특이도와 가장 낮은 위양성률을 보였다. 결론적으로 PCR은 결핵 진단을 위한 신속하고 효율적인 우수한 검사 방법이므로 일상적 임상 검사로의 활용가치가 매우 높다고 하겠다. 그러나 전통적인 여러 방법들 역시 임상상황에 따라 그 나름대로의 특별한 가치를 지니고 있으므로 철저한 정도관리를 통해 PCR과 병행한다면 결핵균 검출율을 보다 높일 수 있으리라 판단된다. In recent years continuously increasing number of tuberculosis (TB) cases due to the emergence of strains with multidrug resistance and AIDS is a significant global health problem. Therefore, more rapid and reliable diagnosis of TB may be one of the most urgent needs in efforts to eradicate the disease. The present study was designed to compare and assess the diagnostic values and efficiencies between the conventional methods (X-ray, AFB stain and culture) and PCR for pulmonary TB on 171 cases. Chest X-ray finding and clinical features revealed that 39 (22.8%) of 171 sputum specimens were pulmonary TB cases. The statistical data were taken on the basis of the definitive diagnosis: In X-ray, overall sensitivity, specificity, efficiency and false positive and false negative incidence was respectively 69.2%, 87.1%, 83.0%, 12.9%, and 30.8%; 79.5%, 95.5%, 91.8%, 4.6% and 20.5% in AFB-stain; 56.4%, 99.2%, 89.5%, 0.8% and 43.6% in culture; 82.1%, 96.2%, 93.0%, 3.8% and 17.9% in PCR. PCR got a highest sensitivity and efficiency as well as a lowest false negative incidence. Culture had a highest specificity with a lowest false positive incidence. These results imply that PCR assay is fast, sensitive and efficient method for diagnosis of pulmonary TB. However, combined use of the conventional methods wish thorough quality control may offer more opportunities for detecting Mycobacterium tuberculosis and diagnosting TB although they have some limits.
지역사회에서 형성된 사회적 지지와 근로자의 사회심리적 스트레스간의 관련성
임화영,김형수,최영환,장성훈,이건세,정최경희,오원기,최재욱,정춘화 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4
Objective: This study was performed to examine the relationship between community-based social support and psychosocial distress in workers. Methods: The study subjects were 596 workers recruited from 11 companies in Chungju city. A structured questionnaire was used to assess sociodemographics, health-related behaviors, job characteristics, job stress, work-based social support, community-based social support and level of psychosocial distress. Results: Hierarchical multiple regression analysis showed that workers with no chronic disease, exercise and sufficient sleep had a higher score of psychosocial distress than those with chronic disease, no exercise, and not enough sleep. Coworker's work-based social support and community-based social support were negatively associated with psychosocial distress. The R square value of total independent variables on psychosocial distress was 0.409, and that of community-based social support on psychosocial distress was 0.052. Conclusion: This study showed that community-based social support served as a protective factor against psychosocial distress in some workers. We recommend the establishment of a worksite stress reduction program in occupational level as well as community-based social support.
Antitumor Components Isolated from the Heartwood Extract of Dalbergia odorifera
Choi, Chun-Whan,Choi, Yeon-Hee,Cha, Mi-Ran,Kim, Young-Sup,Yon, Gyu-Hwan,Kim, Young-Kyoon,Choi, Sang-Un,Kim, Young-Ho,Ryu, Shi-Yong The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.4
Ongoing search for promising antitumor components from plant resources, we found that the methanol extract from the heartwood of Dalbergia odorifera (Leguminosae) demonstrated a significant inhibition on the proliferation of human tumor cell lines including multidrug resistant cells in vitro. Intensive bioassay-guided purification of the extract finally led to the isolation of seven flavonoids and two phenolic components as active constituents for antitumor property, in vitro, i.e., medicarpin (1), 2-hydroxy-3,4-dimethoxybenzaldehyde (2), formononetin (3), tectorigenin (4), mucronulatol (5), (3R)-5'-methoxyvestitol (6), hydroxyobtustyrene (7), liquiritigenin (8), and (3R)-calussequinone (9), respectively.
α-Glucosidase Inhibitiors from Seed Extract of Paeonia Lactiflora
( Chun Whan Choi ),( Yeon Hee Choi ),( Mi Ran Cha ),( Jee Hee Park ),( Young Sup Kim ),( Young Kyoon Kim ),( Sang Un Choi ),( Gyu Hwan Yon ),( Kyung Sik Hong ),( Young Ho Kim ),( Shi Yong Ryu ) 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
Alpha-glucosidase inhibitors are oral antihyperglycemic agents that act on alpha-glucosidase competitively, delaying intestinal carbohydrate absorption and lessening postprandial increases in glucose levels. In the search for new classes of α-glucosidase inhibitors extracted from natural resources, 420 different plant extracts were evaluated for their inhibitory effect on α-glucosidase, in vitro. Amongst the tested extracts, the seed extract of Paeonia lactiflora (Paeoniaceae) demonstrated a significant degree of inhibition on the enzyme, according to dose. Extensive bioassay-guided fractionation of the extract resulted in the isolation of six materials, luteolin (1), resveratrol (2), trans-ε-viniferin (3), gnetin H (4), suffruticosol A (5) and suffruticosol B (6), that are active agents for α-glucosidase inhibition. Resveratrol (2) is a well-known naturally occurring hydroxystilbene, particularly abundant in wine and some related stilbene oligomers. Materials (3-6) exhibited relatively strong inhibition of α-glucosidase and their IC50 values were calculated as: 0.92mM (2), 3.15mM (3), 1.15 mM (4), 2.53mM (5) and 3.15mM (6). In contrast, the (IC50) value of the reference drug, acarbose, was estimated as 8.28mM in vitro.
Antitumor Components Isolated from the Heartwood Extract of Dalbergia odorifera
( Chun Whan Choi ),( Yeon Hee Choi ),( Mi Ran Cha ),( Young Sup Kim ),( Gyu Hwan Yon ),( Young Kyoon Kim ),( Sang Un Choi ),( Young Ho Kim ),( Shi Yong Ryu ) 한국응용생명화학회 2009 Journal of Applied Biological Chemistry (J. Appl. Vol.52 No.4
Antitumor Components Isolated from the Heartwood Extract of Dalbergia odorifera
( Chun Whan Choi ),( Yeon Hee Choi ),( Mi Ran Cha ),( Young Sup Kim ),( Gyu Hwan Yon ),( Young Kyoon Kim ),( Sang Un Choi ),( Young Ho Kim ),( Shi Yong Ryu ) 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.4
Ongoing search for promising antitumor components from plant resources, we found that the methanol extract from the heartwood of Dalbergia odorifera (Leguminosae) demonstrated a significant inhibition on the proliferation of human tumor cell lines including multidrug resistant cells in vitro. Intensive bioassay-guided purification of the extract finally led to the isolation of seven flavonoids and two phenolic components as active constituents for antitumor property, in vitro, i.e., medicarpin (1), 2-hydroxy-3,4-dimethoxybeuzaldehyde (2), formononetin (3), tectorigenin (4), mucronulatol (5), (3R)-5`-methoxyvestitol (6), hydroxyobtustyrene (7), liquiritigenin (8), and (3R)-calussequinone (9), respectively.