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Family History of Cancer and Head and Neck Cancer Risk in a Chinese Population
Huang, Yu-Hui Jenny,Lee, Yuan-Chin Amy,Li, Qian,Chen, Chien-Jen,Hsu, Wan-Lun,Lou, Pen-Jen,Zhu, Cairong,Pan, Jian,Shen, Hongbing,Ma, Hongxia,Cai, Lin,He, Baochang,Wang, Yu,Zhou, Xiaoyan,Ji, Qinghai,Zho Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Background: The aim of this study was to investigate whether family history of cancer is associated with head and neck cancer risk in a Chinese population. Materials and Methods: This case-control study included 921 cases and 806 controls. Recruitment was from December 2010 to January 2015 in eight centers in East Asia. Controls were matched to cases with reference to sex, 5-year age group, ethnicity, and residence area at each of the centers. Results: We observed an increased risk of head and neck cancer due to first degree family history of head and neck cancer, but after adjustment for tobacco smoking, alcohol drinking and betel quid chewing the association was no longer apparent. The adjusted OR were 1.10 (95% CI=0.80-1.50) for family history of tobacco-related cancer and 0.96 (95%CI=0.75-1.24) for family history of any cancer with adjustment for tobacco, betel quid and alcohol habits. The ORs for having a first-degree relative with HNC were higher in all tobacco/alcohol subgroups. Conclusions: We did not observe a strong association between family history of head and neck cancer and head and neck cancer risk after taking into account lifestyle factors. Our study suggests that an increased risk due to family history of head and neck cancer may be due to shared risk factors. Further studies may be needed to assess the lifestyle factors of the relatives.
Amy Chan Hyung Kim,Janelle E. Wells,Yu Kyoum Kim,Pakianathan Chelladurai 한국체육학회 2012 International journal of human movement science Vol.6 No.2
Over the last three decades, hosting mega-sport events have been popular due to political, cultural, and economic benefits. When it comes to maximizing the potential benefits of events, it is critical to manage and satisfy the stakeholders who affect the event or are affected by the event. For this, many management literatures have developed organizational strategies to identify and satisfy influential groups for the pursuit of organizational goals by focusing on dyadic relationships between focal organizations and stakeholder groups. Yet, embracing the fact that these studies tend to ignore the autonomous relationships among stakeholders, this study introduces the model of multi-stakeholder network in mega-sport events settings to highlight the importance of stakeholders’ interactions. The purpose of this study is: 1) to develop a conceptual framework for the model of multi-stakeholder network employing an issue-focused stakeholder management approach and social network analysis in mega-sport events settings, and 2) to simulate a model by creating a random stakeholder network from the issue categories and external stakeholder groups identified by Parent (2008) to provide empirical implications. The theoretical, methodological, and practical implications of the model, and future directions are discussed.
Evaluation of children's after-school programs in Taiwan: FAHP approach
Amy H. I. Lee,Chih-Neng Yang,Chun-Yu Lin 서울대학교 교육연구소 2012 Asia Pacific Education Review Vol.13 No.2
The need of after-school programs has become urgent for school-age children in many industrialized countries due to social structure changes. This research develops a hierarchical framework to evaluate after-school programs from two distinct aspects-service quality from parents' perspectives and marketing strategy from operators' perspectives-each aspect respectively associated with five mutually independent criteria. Two different questionnaire surveys are conducted respectively to parents and providers in Hsinchu, Taiwan based on pairwise comparison on Saaty's nine-point scale. Fuzzy analytic hierarchy process is then employed to calculate the relative importance of the criteria under each aspect. The results show that the top three concerns from parents' perspectives are communication and attentiveness, teacher qualification and counseling, and fee and location, whereas the top three concerns from operators' perspectives are promotion, price, and product. Our findings reveal a consistency between the concerns of parents and of operators, but the important rankings from the two perspectives are not exactly the same, implying that the parents and the operators do have somewhat different viewpoints in evaluating the after-school programs.
Liew Amy Kia Cheen,Yeh Yi-Chun,Abdullah Dalia,Tu Yu-Kang 대한치과보존학회 2021 Restorative Dentistry & Endodontics Vol.46 No.3
Objectives This study aimed to evaluate the efficacy of various local anesthesia (LA) in vital asymptomatic teeth. Materials and Methods Randomized controlled trials comparing pulpal anesthesia of various LA on vital asymptomatic teeth were included in this review. Searches were conducted in the Cochrane CENTRAL, MEDLINE (via PubMed), EMBASE, ClinicalTrials.gov, Google Scholar and 3 field-specific journals from inception to May 3, 2019. Study selection, data extraction, and risk of bias assessment using Cochrane Risk of Bias Tool were done by 2 independent reviewers in duplicate. Network meta-analysis (NMA) was performed within the frequentist setting using STATA 15.0. The LA was ranked, and the surface under the cumulative ranking (SUCRA) line was plotted. The confidence of the NMA estimates was assessed using the CINeMA web application. Results The literature search yielded 1,678 potentially eligible reports, but only 42 were included in this review. For maxillary buccal infiltration, articaine 4% with epinephrine 1:100,000 was more efficacious than lidocaine 2% with epinephrine 1:100,000 (odds ratio, 2.11; 95% confidence interval, 1.14–3.89). For mandibular buccal infiltration, articaine 4% with epinephrine 1:100,000 was more efficacious than various lidocaine solutions. The SUCRA ranking was highest for articaine 4% with epinephrine when used as maxillary and mandibular buccal infiltrations, and lidocaine 2% with epinephrine 1:80,000 when used as inferior alveolar nerve block. Inconsistency and imprecision were detected in some of the NMA estimates. Conclusions Articaine 4% with epinephrine is superior when maxillary or mandibular infiltration is required in vital asymptomatic teeth. Objectives This study aimed to evaluate the efficacy of various local anesthesia (LA) in vital asymptomatic teeth. Materials and Methods Randomized controlled trials comparing pulpal anesthesia of various LA on vital asymptomatic teeth were included in this review. Searches were conducted in the Cochrane CENTRAL, MEDLINE (via PubMed), EMBASE, ClinicalTrials.gov, Google Scholar and 3 field-specific journals from inception to May 3, 2019. Study selection, data extraction, and risk of bias assessment using Cochrane Risk of Bias Tool were done by 2 independent reviewers in duplicate. Network meta-analysis (NMA) was performed within the frequentist setting using STATA 15.0. The LA was ranked, and the surface under the cumulative ranking (SUCRA) line was plotted. The confidence of the NMA estimates was assessed using the CINeMA web application. Results The literature search yielded 1,678 potentially eligible reports, but only 42 were included in this review. For maxillary buccal infiltration, articaine 4% with epinephrine 1:100,000 was more efficacious than lidocaine 2% with epinephrine 1:100,000 (odds ratio, 2.11; 95% confidence interval, 1.14–3.89). For mandibular buccal infiltration, articaine 4% with epinephrine 1:100,000 was more efficacious than various lidocaine solutions. The SUCRA ranking was highest for articaine 4% with epinephrine when used as maxillary and mandibular buccal infiltrations, and lidocaine 2% with epinephrine 1:80,000 when used as inferior alveolar nerve block. Inconsistency and imprecision were detected in some of the NMA estimates. Conclusions Articaine 4% with epinephrine is superior when maxillary or mandibular infiltration is required in vital asymptomatic teeth.
Shin, Seungwon,Kim, Jinyoung,Yu, Ami,Seo, Hyung-Sik,Shin, Mi-Ran,Hong, Seung-Ug,Jung, Chan Yung,Kim, Koh-Woon,Cho, Jae-Heung,Lee, Euiju Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>Cervicogenic dizziness is dizziness triggered by movement or positioning of the cervical spine and is often accompanied by neck pain or stiffness. This is a prospective, pragmatic, assessor-blind, randomized controlled trial aimed at testing the efficacy and safety of adjuvant Chuna Manual Therapy (CMT) in patients with cervicogenic dizziness under usual care treatments. Fifty patients with cervicogenic dizziness will be randomly allocated to CMT or usual care (UC) groups in a 1 : 1 ratio. Extensive screening procedures, including examinations for central nervous system problems and nystagmus, will be applied to exclude other dizziness-inducing disorders. The eligible participants will receive 12 sessions of CMT plus UC or only UC over 6 weeks. CMT includes mandatory and discretionary techniques, whereas UC includes electrotherapy, thermotherapy, and patient education. The efficacy will be evaluated primarily as Dizziness Handicap Inventory score. The severity and frequency of dizziness, the level of neck pain or stiffness, and the cervical range of motion will also be evaluated. Safety will be assessed by adverse events. The data will be statistically analyzed at <I>p</I> < 0.05.<I> Trial Registration</I>. This trial was registered with Clinical Research Information Service (CRIS) in Korea, KCT0002565, on 29 November 2017, https://cris.nih.go.kr/cris/search/search_result_st01_kren.jsp?seq=9610<ype=&rtype=.</P>
Shin, Seungwon,Kim, Jinyoung,Yu, Ami,Seo, Hyung-Sik,Shin, Mi-Ran,Cho, Jae-Heung,Yi, Gilhee,Hong, Seung-Ug,Lee, Euiju Hindawi 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-
<P>This study protocol aims to explore the effectiveness, safety, and cost-effectiveness of a herbal medication,<I> Gongjindan</I> (GJD), in patients with chronic dizziness. This will be a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group, clinical trial. Seventy-eight patients diagnosed with Meniere's disease, psychogenic dizziness, or dizziness of unknown cause will be randomized and allocated to either a GJD or a placebo group in a 1 : 1 ratio. Participants will be orally given 3.75 g GJD or placebo in pill form once a day for 56 days. The primary outcome measure will be the Dizziness Handicap Inventory score. Secondary outcome measures will be as follows: severity (mean vertigo scale and visual analogue scale) and frequency of dizziness, balance function (Berg Balance Scale), fatigue (Fatigue Severity Scale) and deficiency pattern/syndrome (qi blood yin yang-deficiency questionnaire) levels, and depression (Korean version of Beck's Depression Inventory) and anxiety (State-Trait Anxiety Inventory) levels. To assess safety, adverse events, including laboratory test results, will be monitored. Further, the incremental cost-effectiveness ratio will be calculated based on quality-adjusted life years (from the EuroQoL five dimensions' questionnaire) and medical expenses. Data will be statistically analyzed at a significance level of 0.05 (two-sided). This trial is registered with ClinicalTrials.gov NCT03219515, in July 2017.</P>