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- 저자 : 허성구 (검색결과 87 건)
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Genetic Risk Prediction for Normal-Karyotype Acute Myeloid Leukemia Using Whole-Exome Sequencing
허성구,홍은표,박지완 한국유전체학회 2013 Genomics & informatics Vol.11 No.1
Normal-karyotype acute myeloid leukemia (NK-AML) is a highly malignant and cytogenetically heterogeneous hematologic cancer. We searched for somatic mutations from 10 pairs of tumor and normal cells by using a highly efficient and reliable analysis workflow for whole-exome sequencing data and performed association tests between the NK-AML and somatic mutations. We identified 21 nonsynonymous single nucleotide variants (SNVs) located in a coding region of 18 genes. Among them, the SNVs of three leukemia-related genes (MUC4, CNTNAP2, and GNAS) reported in previous studies were replicated in this study. We conducted stepwise genetic risk score (GRS) models composed of the NK-AML susceptible variants and evaluated the prediction accuracy of each GRS model by computing the area under the receiver operating characteristic curve (AUC). The GRS model that was composed of five SNVs (rs75156964, rs56213454, rs6604516, rs10888338, and rs2443878) showed 100% prediction accuracy, and the combined effect of the three reported genes was validated in the current study (AUC, 0.98; 95% confidence interval, 0.92 to 1.00). Further study with large sample sizes is warranted to validate the combined effect of these somatic point mutations, and the discovery of novel markers may provide an opportunity to develop novel diagnostic and therapeutic targets for NK-AML.
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첨단 전자산업 폐수처리시설의 Water Digital Twin(II): e-ASM 모델 보정, 수질 예측, 공정 선택과 설계
허성구,정찬혁,이나희,심예림,우태용,김정인,유창규 한국청정기술학회 2022 청정기술 Vol.28 No.1
In this study, an electronics industrial wastewater activated sludge model (e-ASM) to be used as a Water Digital Twinwas calibrated based on real high-tech electronics industrial wastewater treatment measurements from lab-scale and pilot-scalereactors, and examined for its treatment performance, effluent quality prediction, and optimal process selection. For specializedmodeling of a high-tech electronics industrial wastewater treatment system, the kinetic parameters of the e-ASM were identifiedby a sensitivity analysis and calibrated by the multiple response surface method (MRS). The calibrated e-ASM showed a highcompatibility of more than 90% with the experimental data from the lab-scale and pilot-scale processes. Four electronics industrial wastewater treatment processes—MLE, A2/O, 4-stage MLE-MBR, and Bardenpo-MBR—were implemented with the proposedWater Digital Twin to compare their removal efficiencies according to various electronics industrial wastewater characteristics. Bardenpo-MBR stably removed more than 90% of the chemical oxygen demand (COD) and showed the highest nitrogen removalefficiency. Furthermore, a high concentration of 1,800 mg L-1 TMAH influent could be 98% removed when the HRT of theBardenpho-MBR process was more than 3 days. Hence, it is expected that the e-ASM in this study can be used as a Water DigitalTwin platform with high compatibility in a variety of situations, including plant optimization, Water AI, and the selection of bestavailable technology (BAT) for a sustainable high-tech electronics industry. 본 연구에서는 Part I에서 제안한 첨단 전자산업 폐수처리시설 특화 Water Digital Twin모델인 e-ASM을 이용하여 랩-파일럿 처리장 데이터를 바탕으로 모델 보정(Calibration), 유입 성상에 따른 제거 효율, 유출수 예측 및 최적 공법 선정을 수행하였다. 첨단전자산업 폐수처리시설의 특화 모델링을 위하여, 민감도 분석을 통해 e-ASM 모델의 정합성과 상관성이 높은 동역학적 파라미터를 선정하였고, 다중반응표면분석법 (Multiple response surface methodology, MRS)을 이용하여 동역학적 파라미터를 보정하였다. e-ASM 모델의 보정 결과, Lab-scale, Pilot-scale 단위의 실험데이터와 90% 이상의 높은 정합성을 보였다. 그리고 4가지 유기폐수 처리처리공법인 MLE, A2/O, 4-stage MLE-MBR, Bardenpho-MBR을 제안한 Water Digital Twin으로 구현하여 유입 폐수의 성상별 운전조건에 따라 제거효율을 분석하였으며, Bardenpho-MBR이 C/N ratio 변화에서도 안정적으로 COD (Chemicaloxygen demand)를 90% 이상 제거하며 높은 총 질소 제거 효율을 보였다. 그리고 유입 폐수의 조건별 Bardenpho-MBR공정의수리학적 체류시간(Hydraulic retention time, HRT)이 3일 이상일 때 1,800 mg L-1의 고농도 TMAH 폐수를 98% 이상 제거할 수있음을 확인할 수 있었다. 이와 같이, 본 연구에서 개발한 e-ASM은 전자산업 제조시설별, 유입 폐수의 성상별 특화 모델링을 통해 높은 정합성을 가진 전자산업 폐수처리공정의 Water Digital Twin를 구현할 수 있고, 최적운전, Water AI, 최적가용기법 선정등의 응용 가능성을 바탕으로 지속 가능한 첨단전자 산업을 위해 활용될 수 있을 것으로 사료된다.
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허성구,김기성,안재훈,임경재,최중대,Heo, Seong-Gu,Kim, Gi-Seong,An, Jae-Hun,Im, Gyeong-Jae,Choe, Jung-Dae 한국관개배수위원회 2006 한국관개배수논문집 Vol.13 No.2
The Soil and Water Assessment Tool (SWAT) model has been widely used in hydrology and sediment simulation worldwide. In most cases, the SWAT model is first calibrated with adjustments in model parameters, and then the validation is performed. However, very little study regarding the effects on SWAT estimation of subwatershed delineation was performed. Thus, the SWAT model was applied to the Doam-dam watershed with various threshold values in subwatershed delineation in this study to examine the effects on the number of subwatershed delineated on SWAT estimation. It was found the flow effect of subwatershed delineation is negligible. However there were huge variations in SWAT estimated sediment, T-N, and T-P values with the use of various threshold value in watershed delineation. Sometimes these variations due to watershed delineation are beyond the effects of parameter adjustment in model calibration and validation. The SWAT is a semi-distributed modeling system, thus, the subwatershed characteristics are assumed to be the same for all Hydrologic Response Unit (HRU) within that subwatershed. This assumption leads to variations in the SWAT estimated sediment and nutrient output values. Therefore, it is strongly recommended the SWAT users need to use the HUR specific slope length and slope value in model runs, instead of using the slope and the corresponding slope length of the subawatershed to exclude the effects of the number of subwatershed delineated on the SWAT estimation.
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객토 농경지의 토양특성을 고려한 도암댐 유역에서의 수문 및 유사 거동 모의
허성구,김재영,유동선,김기성,안재훈,윤정숙,임경재,Heo, Sung-Gu,Kim, Jae-Young,Yoo, Dong-Sun,Kim, Ki-Sung,Ahn, Jae-Hun,Yoon, Jong-Suk,Lim, Kyoung-Jae 한국농공학회 2007 한국농공학회논문집 Vol.49 No.2
The alpine agricultural activities are usually performed at higher and steep areas in nature. Thus, significant amounts of soil erosion are occurring compared with those from other areas. Thus, the soil erosion induced environmental impacts in these areas are getting greater. The Doam watershed is located at alpine areas and it has been well known that the agricultural activities in the watershed are causing accelerated soil erosion and water quality degradations. Many modeling approaches were employed to solve soil erosion and water quality issues. In this study, the Soil and Water Assessment Tool (SWAT) model was utilized to simulate the hydrologic and sediment behaviors in the Doam watershed. In many previous modeling studies, the digital soil map and its corresponding soil properties were used without modification to reflect soil conditioning at many agricultural fields of the Doam watershed. Thus, the soil sample was taken at the agricultural field within the Doam watershed and analyzed for its physical properties. In this study, the digital topsoil properties in the agricultural fields within the Doam watershed were replaced with the soil properties for reconditioned soil analyzed in this study to simulate the impacts of using soil properties for reconditioned soil in hydrologic and sediment modeling at the Doam watershed using the SWAT model. The hydrologic component of the SWAT model was calibrated and validated for measured flow data from 2002 to 2003. The $R^2$ value was 0.79 and the EI value was 0.53 for weekly simulated data. The calibrated model parameters were used for hydrologic component validation and the $R^2$ value was 0.86 and the EI value was 0.74 for weekly data. For sediment comparison, the $R^2$ value was 0.67 and the EI value was 0.59. These statistics improved with the use of soil properties of the reconditioned soil in the field compared with the results obtained without considering soil reconditioning. The simulated sediment amounts with and without considering the soil properties of the reconditioned soil were 284,813 ton and 158,369 ton, respectively. This result indicates that there could be approximately 79% of errors in estimated sediment yield at the Doam watershed, although the model comparison with the measured data gave similar satisfactory statistics with and without considering soil properties from the reconditioned soil.
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허성구 ( Heo Sung-gu ),임경재 ( Lim Kyoung-jae ),김기성 ( Kim Ki-sung ),사공명 ( Myung Sagong ),안재훈 ( An Jae-hun ) 한국농공학회 2005 한국농공학회 학술대회초록집 Vol.2005 No.-
Doam watershed is located at alpine areas in the Kangwon province. The annual average precipitation, including snow accumulation during the winter, at the Doam watershed is significantly higher than other areas. Thus, pollutant laden runoff and sediment discharge from the alpine agricultural fields are causing water quality degradation at the Doam watershed. To estimate soil erosion from the agricultural fields, the Universal Soil Loss Equation (USLE) has been widely used because of its simplicity to use. The USLE rainfall erosivity (R) factor is responsible for impacts of rainfall on soil erosion. Thus, use of constant R factor for the Doam watershed cannot reflect variations in precipitation patterns, consequently soil erosion estimation. In the early spring at the Doam watershed, the stream flow increases because of snow melt, which results in erosion of loosened soil experiencing freezing and thaw during the winter. However, the USLE model cannot consider the impacts on soil erosion of freezing and thaw of the soil. Also, it cannot simulate temporal changes in USLE input parameters. Thus, the Soil and Water Assessment Tool (SWAT) model was investigated for its applicability to estimate soil erosion at the Doam watershed, instead of the widely used USLE model. The SWAT hydrology and erosion/sediment components were validated after calibration of the hydrologic component. The R<sup>2</sup> and Nash-Sutcliffe coefficient values are higher enough, thus it was found the SWAT model can be efficiently used to simulate hydrology and sediment yield at the Doam watershed. The effects of snow melt on SWAT estimated stream flow and sediment were investigated using long-term precipitation and temperature data at the Doam watershed. It was found significant amount of flow and sediment in the spring are contributed by melting snow accumulated during the winter. Thus, it is recommend that the SWAT model capable of simulating snow melt and long-term weather data needs to be used in estimating soil erosion at alpine agricultural land instead of the USLE model for successful soil erosion management at the Doam watershed.
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도암댐 유역의 산림 파편화에 따른 수(水)환경 영향 평가
허성구 ( Sung-gu Heo ),김기성 ( Ki-sung Kim ),안재훈 ( Jae-hun Ahn ),윤정숙 ( Jong-suk Yoon ),임경재 ( Kyoung Jae Lim ),최중대 ( Joongdae Choi ),신용철 ( Yong-chul Shin ),유창원 ( Changwon Lyou ) 한국농공학회 2006 한국농공학회 학술대회초록집 Vol.2006 No.-
The water quality impacts of forest fragmentation at the Doam-dam watershed were evaluated in this study. For this ends, the watershed scale model, Soil and Water Assessment Tool (SWAT) model was utilized. To exclude the effects of different magnitude and patterns in weather, the same weather data of 1985 was used because of significant differences in precipitation in year 1985 and 2000. The water quality impacts of forest fragmentation were analyzed temporarily and spatially because of its nature. The flow rates for Winter and Spring has increased with forest fragmentations by 8,366㎥/month and 72,763㎥/month in the S1 subwatershed, experiencing the most forest fragmentation within the Doam-dam watershed. For Summer and Fall, the flow rate has increased by 149,901 ㎥/month and 107,109㎥/month, respectively. It is believed that increased flow rates contributed significant amounts of soil erosion and diffused nonpoint source pollutants into the receiving water bodies. With the forest fragmentation in the S1 watershed, the average sediment concentration values for Winter and Spring increased by 5.448mg/L and 13.354mg/L, respectively. It is believed that the agricultural area, which were forest before the forest fragmentation, are responsible for increased soil erosion and sediment yield during the spring thaw and snow melts. For Spring and Fall, the sediment concentration values increased by 20.680mg/L and 24.680mg/L, respectively. Compared with Winter and Spring, the increased precipitation during Summer and Fall contributed more soil erosion and increased sediment concentration value in the stream. Based on the results obtained from the analysis performed in this study, the stream flow and sediment concentration values has increased with forest fragmentation within the S1 subwatershed. These increased flow and soil erosion could contribute the eutrophication in the receiving water bodies. This results show that natural functionalities of the forest, such as flood control, soil erosion protection, and water quality improvement, can be easily lost with on-going forest fragmentation within the watershed. Thus, the minimize the negative impacts of forest fragmentation, comprehensive land use planning at watershed scale needs to be developed and implemented based on the results obtained in this research.
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고랭지 농업의 작물별 객토량 변화에 따른 토양유실 저감 분석
허성구 ( Sung Gu Heo ),전만식 ( Man Sig Jun ),박상헌 ( Sang Hun Park ),김기성 ( Ki Sung Kim ),강성근 ( Sung Keun Kang ),옥용식 ( Yong Sik Ok ),임경재 ( Kyoung Jae Lim ) 한국물환경학회 2008 한국물환경학회지 Vol.24 No.2
There is increased soil erosion potential at highland agricultural crop fields because of its topographic characteristics and site-specific agricultural management practices performed at these areas. The agricultural upland fields are usually located at the sloping areas, resulting in higher soil loss, pesticides, and nutrients in case of torrential rainfall events or typhoon, such as 2002 Rusa and 2003 MaeMi. At the highland agricultural fields, the soil reconditioning have been performed every year to decrease damage by continuous cropping and pests. Also it has been done to increase crop productivity and soil fertility. The increased amounts of soil used for soil reconditioning are increasing over the years, causing significant impacts on water quality at the receiving water bodies. In this study, the field investigation was done to check soil reconditioning status for potato, carrot, and cabbage at the Doam-dam watershed. With these data obtained from the field investigation, the Soil and Water Assesment Tool (SWAT) model was used to simulate the soil loss reduction with environment-friendly and agronomically enough soil reconditioning. The average soil reconditioning depth for potato was 34.3 cm, 48.3 cm for carrot, and 31.2 cm for cabbage at the Doam-dam watershed. These data were used for SWAT model runs. Before the SWAT simulation, the SWAT ArcView GIS Patch, developed by the Kangwon National University, was applied because of proper simulation of soil erosion and sediment yield at the sloping watershed, such as the Doam-dam watershed. With this patch applied, the Coefficient of Determination (R2) value was 0.85 and the Nash-Sutcliffe Model Efficiency (EI) was 0.75 for flow calibration. The R2 value was 0.87 and the EI was 0.85 for flow validation. For sediment simulation, the R2 value was 0.91 and the EI was 0.70, indicating the SWAT model predicts the soil erosion processes and sediment yield at the Doam-dam watershed. With the calibrated and validated SWAT for the Doam-dam watershed, the soil erosion reduction was investigated for potato, carrot, and cabbage. For potato, around 19.3 cm of soil were over applied to the agricultural field, causing 146% of more soil erosion rate, approximately 33.3 cm, causing 146% of more soil erosion for carrot, and approximately 16.2 cm, causing 44% of more soil erosion. The results obtained in this study showed that excessive soil reconditioning are performed at the highland agricultural fields, causing severe muddy water issues and water quality degradation at the Doam-water watershed. The results can be used to develop soil reconditioning standard policy for various crops at the highland agricultural fields, without causing problems agronomically and environmentally.
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