http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
정혜나,한부경,고은영,신정희 한국유방암학회 2014 Journal of breast cancer Vol.17 No.3
Purpose: The aim of this study is to describe our initial experiencewith magnetic resonance (MR)-guided biopsy and to determinethe malignancy rate of additional lesions identified by MR only inKorean women with breast cancer. Methods: A retrospective reviewidentified 22 consecutive patients with breast cancer whohad undergone MR-guided vacuum-assisted biopsies (VAB) ofMR-only identified lesions from May 2009 to October 2011.Weevaluated the rate of compliance, the technical success for MRguidedVAB and the MR imaging findings of the target lesions. VAB histology was compared with surgical histology and followupimaging findings. Results: The biopsy recommendations forMR-only identified lesions were accepted in 46.8% (22/47) ofpatients. One of 22 procedures failed due to the target’s posteriorlocation. Among 21 MR-guided VAB procedures, the target lesionswere considered as a mass in 12 cases and a nonmassenhancement in nine cases. VAB histology revealed malignanciesin 14% (3/21) of cases, high-risk lesions in 24% (5/21) andbenign lesions in 62% (13/21). Eleven cases (52%, 11/21) had apositive surgical correlation, and one of them was upgraded fromatypical ductal hyperplasia to invasive ductal carcinoma. In theremaining 10 lesions, follow-up breast ultrasound and mammographywere available (range, 15–44 months; mean, 32.1 months)and did not show suspicious lesions. The final malignancy ratewas 19% (4/21). Conclusion: MR-guided VAB for MR-only identifiedlesions yielded a 19% malignancy rate in Korean womenwith breast cancer. MR-guided VAB helps surgeons avoid an unnecessarywide excision or additional excisional biopsy.
정혜임,Junwei Liang,정유나,임동빈 한국미생물학회 2015 The journal of microbiology Vol.53 No.12
Exonuclease VII (ExoVII) of Escherichia coli is a single strandspecific DNA nuclease composed of two different subunits: the large subunit, XseA, and the small subunit, XseB. In this study, we found that multicopy single-stranded DNAs (msDNAs), Ec83 and Ec78, are the in vivo substrates of ExoVII; the enzyme cuts the phosphodiester bond between the fourth and fifth nucleotides from the 5 end. We used this msDNA cleavage to assess ExoVII activity in vivo. Both subunits were required for enzyme activity. Expression of XseA without XseB caused cell death, even though no ExoVII activity was detected. The lethality caused by XseA was rescued by surplus XseB. In XseA-induced death, cells were elongated and multinucleated, and their chromosomes were fragmented and condensed; these are the morphological hallmarks of apoptotic cell death in bacteria. A putative caspase recognition sequence (FVAD) was found in XseA, and its hypothetical caspase product with 257 amino acids was as active as the intact protein in inducing cell death. We propose that under ordinary conditions, XseA protects chromosome as a component of the ExoVII enzyme, but in some conditions, the protein causes cell death; the destruction of cell is probably carried out by the amino terminal fragment derived from the cleavage of XseA by caspase-like enzyme.
Cavernous Hemangioma of the Uterus in a Postmenopausal Woman - A Case Report -
정혜라,조치흠,권상훈,권선영 대한병리학회 2011 Journal of Pathology and Translational Medicine Vol.45 No.5
Cavernous hemangioma of the uterus is an uncommon mesenchymal tumor. Most cases have been reported in young, pregnant women and the condition is very rare in a postmenopausal patient. An 81-year-old woman presented with a huge pelvic mass. Abdominal computed tomography and magnetic resonance imaging results suggested a leiomyoma with degenerative change and hemorrhage. Microscopically, large, thick-walled and variable-sized vascular channels were evident in the majority part of myometrium; the lining cells were immunohistochemically reactive for CD31. Vascular tumors of the female genital tract should be cautiously excised due to the profuse intra-operative bleeding. The pathological examination of a hysterectomy specimen is the only method to confirm the diagnosis of this tumor.