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장익순,임지헌,박상철,여의주 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.2
Lysophosphatidic acid (LPA) is a phospholipid growth factor that acts through G-protein-coupled receptors. Previously, we demonstrated an altered profile of LPA-dependent cAMP content during the aging process of human diploid fibroblasts (HDFs). In attempts to define the molecular events asso-ciated with the age-dependent changes in cAMP profiles, we determined the protein kinase A (PKA) activity, phosphorylation of cAMP-response ele-ment binding protein (CREB), and the protein expression of CRE-regulatory genes, c-fos and COX-2 in young and senescent HDFs. We observed in senescent cells, an increase in mRNA levels of the catalytic subunit α of PKA and of the major regulatory subunit I α . Senescence-associated increase of cAMP after LPA treatment correlated well with increased CREB phosphorylation accompanying activation of PKA in senescent cells. In senescent cells, after LPA treatment, the expression of c-fos and COX-2 decreased initially, followed by an increase. In young HDFs, CREB phosphorylation decreased following LPA treatment, and both c-fos and COX-2 protein levels increased rapidly. CRE-luciferase assay revealed higher basal CRE-dependent gene expression in young HDFs compared to senescent HDFs. However, LPA-dependent slope of luciferase increased more rapidly in senescent cells than in young cells, presumably due to an increase of LPA-induced CREB phosphorylation. CRE-depen -dent luciferase activation was abrogated in the presence of inhibitors of PKC, MEK1, p38MAPK, and PKA, in both young and senescent HDFs. We conclude that these kinase are coactivators of the expression of CRE-responsive genes in LPA-indu -ced HDFs and that their changed activities during the aging process contribute to the final expression level of CRE-responsive genes.
A NOTE ON FUNCTIONAL INEQUALITY AND ADDITIVE MAPPING
장익순,이현욱,김학만 충청수학회 2022 충청수학회지 Vol.35 No.2
In this note, we prove some theorems concerning the stability of functional inequality associated with additive mappings on quasi-$\beta$-normed spaces.
On stability of the orthogonally cubic type functional equation
장익순 충청수학회 2006 충청수학회지 Vol.19 No.3
In this article, we establish the stability of the orthog-onally cubic type functional equation 2 f(x + 2 y) + 2 f(x 2y) +2f(2x)+7[f(x)+ f( x)] = 4f(x)+8[f(x + y)+ f(x y)]; x? y inwhich ? is the orthogonality in the sense in the Ratz.
장익순,이재곤 대한기계학회 1992 大韓機械學會誌 Vol.32 No.10
여기에서는 삼원촉매 장착엔진을 정밀하게 제어(연료 제어, 공회전 제어, 점화시기 제어, Purge Air 제어 등)하여 삼원촉매의 효율을 향상시키고, 그 결과 배기가스를 감소시킴과 더불어 운전성 및 동력성능을 향상시킨 엔진 전자 제어 시스템의 개요를 간단히 소개하였다. 앞으로도 북미지 역의 배기가스 관련법규가 더욱 강화될 것으로 예상되며, 이에 대응한 엔진 제어 시스템에 대한 지속적인 연구 개발이 필요하리라 생각된다.