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오화은,송지선,류기영,이선 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.4
Well differentiated papillary mesothelioma (WDPM) is an unusual variant of epithelial mesothelioma. Most WDPMs exhibit either benign or indolent behavior. Making the differential diagnosis between this rare tumor and serous papillary carcinoma can be problematic. We report here on a case of a 43-year-old woman with a WDPM of the surface. She presented to our hospital for a routine gynecologic evaluation, and she had no specific symptoms or a history of asbestos exposure. Gynecologic ultrasonography revealed a right ovarian mass that measured 6×3.8× 3 cm in size. No ascites was detected. Right salpingo-oophorectomy was performed; grossly, the tumor was a yellowish firm, multinodular mass. Microscopically, the tumor consisted of numerous papillae that were lined by a single layer of uniform mesothelial cells. Nuclear pleomorphism and mitoses were not found. On immunohistochemical study, the tumor cells were positive for calretinin and cytokeratin, but they were negative for CEA. It is important to differentiate WDPM from serous papillary carcinoma or other malignant tumors to avoid treating them as malignant tumors.
톡소플라즈마 림프절염에서 발견된 톡소플라즈마 충란 -1예 보고-
오화은,김인선 대한병리학회 2004 Journal of Pathology and Translational Medicine Vol.38 No.5
Toxoplasmic lymphadenitis is the most frequently observed clinical form of acquired toxoplasmosis. It is diagnosed by observing the characteristic histopathology, performing serologic tests and demonstrating the organisms. However, detection of the organisms in lymph node section is rarely accomplished. We demonstrate a case of a toxoplasmic lymphadenitis of a 40-year-old man with bradyzoites. The histopathologic findings of the lymph nodes showed reactive follicular hyperplasia associated with the presence of irregular clusters of epithelioid histiocytes, usually located in the cortical and paracortical zones, and monocytoid B cell proliferation. We demonstrated the bradyzoites of Toxoplasma gondii with periodic acid-Schiff (PAS)-stain, and serologic testing showed positive Ig-G and Ig-M toxoplasma antibodies.
흉막강액에서 진단된 악성 섬유성 조직구종 - 1예 보고 -
오화은,김유훈,조성진,김영식,김인선,Oh, Hwa-Eun,Kim, Yoo-Hoon,Cho, Seong-Jin,Kim, Young-Sik,Kim, In-Sun 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.1
Malignant fibrous histiocytoma is the most common soft tissue sarcoma of late adult life, but it is rare in the pleura. We recently experienced a case of cytology of malignant fibrous histiocytoma in plural fluid. The smear revealed histiocytic malignant cells, spindle malignant cells and inflammatory cells. The histiocytic cells showed abundant, pale cytoplasm and ovoid, irregular eccentrically-placed nuclei. The spindle cells showed elongated nuclei. Intercellular collagen was also present.
Diagnosis of Intestinal Tuberculosis by Polymerase Chain Reaction
Oh, Hwa Eun,Cho, Hyun Deuk,Choi, Jong Sang 고려대학교 의과대학 1998 고려대 의대 잡지 Vol.35 No.3
장결핵이 의심되는 42예의 생검 혹은 절제된 조직에서 PCR과 AFB 염색, 그리고 Rhodamine-Auramine 형광 염색(RAF-AFB)을 시행했다 환자는 만성 설사와 복통을 호소하였고 복통이 가장 흔한 증상이었다(76%). 병리학적 소견상, 10예에서 만성 건락성 육아종성염증으로 진단되었고. 32예는 만성 비건락성 육아종성 염증으로 진단되었다. Ziehl-Neelsen(ZN) AFB 염색에서 25예 중 11예에서 결핵균이 관찰되었으며(44%) Rhodamine-Auramine 형광 염색에서는 25예 중 13예에서 결핵균이 관찰되었다(52%). 25예 중 9예에서 Ziehl-Neelsen(ZN) AFB염색과 RAF-AFB 염색 모두에서 결핵균이 관찰되었으며. 6예는 두 AFB 염색중 어느 하나에서 결핵균을 관찰할 수 있었으므로 15예에서 결핵균을 관찰할 수 있었다(60%). PCR에서 전체 42예 중 8예에서 결핵균의 DNA를 확인할 수 있었다(19%). 비록 PCR이 장결핵의 진단에 있어서 빠르고, 민감한 방법이기는 하나, 우리의 실험결과에 의하면 상대적으로 덜 민감한 방법이었다. 그러므로, 결핵균을 검출하는데 있어서 AFB 염색과 PCR을 병행하는 것이 진단의 정확도를 높일 수 있으리라 생각한다. With 42 endoscopically biopsied or resected tissues, we performed a polymerase chain reaction(PCR), acid fast bacilli(AFB) stain assay and Rhodamine-Auramine fluorescent acid-fast (RAF-AFB) staining. With clinical impressions of intestinal tuberculosis, specimens were obtained from patients with chronic diarrhea or abdominal pain. Abdominal pain was the most common symptom (76%). On pathologic findings, ten of forty-two cases were diagnosed as chronic caseating granulomatous inflammation and thirty-two cases were diagnosed as chronic noncaseating granulomatous inflammation. Ziehl-Neelsen(ZN) stain from formalin-fixed, paraffin-embedded tissue revealed AFB in eleven of twenty-five cases(44%). Rhodamine-Auramine fluorescent acid-fast staining revealed AFB in thirteen of 25 cases(52%). Nine of 25 cases showed AFB on both ZN and RAF-AFB stainings and six of 25 cases showed AFB one each of ZN and RAF-AFB stainings, the resulting fifteen of 25 cases(60%) showed AFB with special stains. M. tuberculosis DNA was identified in 8 of 42 cases(l9%) by PCR, two cases of the positive eight cases and six cases without AFB stainings revealed positive findings on Tb-PCR. Although PCR is known a s a rapid, sensitive, and specific method for the diagnosis of intestinal tuberculosis, our study showed relatively low sensitivity and specificity, which might be caused by low numbers of organisms in the specimen and/or inadequate specimen. Therefore, for the detection of M. tuberculosis, diagnostic accuracy will be increased when both AFB stain and PCR are determined.
어깨의 피하조직에 발생한 기관지기원낭 - 1예 보고 -
송지선,오화은,이상엽,박노혁,김호영 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.1
Bronchogenic cyst is an uncommon congenital anomaly that arises from maldevelopment of the primitive foregut, and is usually found in the lung and mediastinum. Cutaneous or subcutaneous bronchogenic cysts are rare, and occur especially in the shoulder region. We report here on a 40-year-old woman with a soft, nontender, cystic mass on the upper posterior aspect of the right acromioclavicular joint; this had been recognized about 20 years before. She underwent incision and drainage of the lesion at a local clinic about 1 year ago, but the wound was not healed. MRI showed an irregular-shaped dark signal intensity lesion that measured 2×1.5cm in the subcutaneous fat layer. Microscopically, the cyst was lined by pseudostratified ciliated columnar epithelium that displayed squamous metaplasia. The cyst wall revealed frequent smooth muscle bundles, occasional seromucous glands and multifocal lymphocytic infiltration. This is the first reported case of subcutaneous bronchogenic cyst of the shoulder in a Korean adult.