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        원발성 포도막흑색종의 진단을 위한 영상의학적 검사

        배정훈,송원경,변석호,이성철,Jeong Hun Bae,Won Kyung Song,Suk Ho Byeon,Sung Chul Lee 대한안과학회 2008 대한안과학회지 Vol.49 No.9

        Purpose: To investigate various imaging techniques for the diagnosis of primary uveal melanomas in Korean patients. Methods: We retrospectively reviewed the medical records of 35 eyes in 35 patients (22 males, 13 females) diagnosed with uveal melanomas between September 2004 and December 2006. The findings of fundus photographs, ultrasonography, CT scan, MRI, and PET scan were documented. Results: A/B scan ultrasonography showed typical findings of uveal melanomas in 74.3% (26 eyes) of the patients. On CT scan, the mass appeared as a homogenous hyperdense lesion, and on MRI, the typical signal of hyperintensity on the T1-weighted image and hypointensity on the T2-weighted image was seen in 89.3% (25 eyes), with contrast enhancement in only 46.4% (13 eyes) of the patients. A PET scan revealed positive tumor uptake in 22.7% (5 eyes) of the patients. Conclusions: Although ultrasonography is the most useful and accurate method for the diagnosis of uveal melanoma, it provides more atypical cases in Korean patients than Caucasian patients. CT scans and MRI can be used for a differential diagnosis, but the diagnostic efficacy of PET scans is low. J Korean Ophthalmol Soc 2008;49(9):1461-1467

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        위장관 출혈 후 발생한 양측성 앞허혈시신경병증 1예

        고재상,김규아,신주연,변석호,Jae Sang Ko,Gyu Ah Kim,Joo Youn Shin,Suk Ho Byeon 대한안과학회 2014 대한안과학회지 Vol.55 No.1

        Purpose: To introduce a case of bilateral anterior ischemic optic neuropathy (AION) after blood loss due to gastrointestinal bleeding. Case summary: A 50-year-old male patient with a history of type 1 diabetes mellitus and alcoholic liver cirrhosis presented with 3 days of melena and 1 day of general weakness and dizziness. Initial hemoglobin level was 4.7 g/dL and blood pressure was 100/55 mm Hg. On esophagogastroduodenoscopy, a peptic ulcer with evident recent bleeding was observed. After transfusion of packed red blood cells and endoscopic hemostasis of bleeding, his general condition improved but he complained of blurred vision in both eyes which developed immediately after the onset of melena. Initial best-corrected visual acuity (BCVA) was 0.5 in his right eye and 0.6 in the left eye. On fundus examination, swollen optic disc with blurred margin was noted and he had constricted visual fields. On follow-up, the patient received posterior subtenon triamcinolone injection in his right eye. After the procedure, the BCVA was improved to 0.8 in both eyes, but he still had bilateral pale optic disc with constricted visual field. Conclusions: In the case of visual loss after recent blood loss, AION should be considered as a diagnosis, which can present as bilateral involvement. J Korean Ophthalmol Soc 2014;55(1):161-166

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        신생혈관녹내장이 동반된 유리체강내 유구낭충증 1예

        고재상,김규아,신주연,변석호,Jae Sang Ko,MD,Gyu Ah Kim,MD,Joo Youn Shin,MD,Suk Ho Byeon,MD,PhD 대한안과학회 2013 대한안과학회지 Vol.54 No.10

        Purpose: To introduce a case of intravitreal cysticercosis presenting as neovascular glaucoma. Case summary: A 42-year-old female who lives in the Philippines visited our clinic complaining of reduced visual acuity and decreased visual field in her right eye. She was treated at another clinic for neovascular glaucoma and posterior uveitis. Initial best-corrected visual acuity was 0.7 and intraocular pressure was 13 mm Hg with Goldmann applanation tonometry. Slit lamp examination showed inflammatory cells in the anterior chamber and vitreous with florid new vessel on iris. On fundus examination, a cystic lesion without movement was observed in the superonasal vitreous as well as tractional band. As other retinal vascular diseases were not observed on fluorescein angiography, the patient was diagnosed with secondary neovascular glaucoma due to cysticercosis. After a single course of intravitreal bevacizumab injection and cyst removal with pars plana vitrectomy, the best-corrected visual acuity was 0.5 and intraocular pressure was 14 mm Hg without recurrence of iris neovascularization during the 3 months of follow-up.

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        유리체 절제술 후 안압 상승 환자에서 무보존제 도르졸라미드-티몰롤 복합제제의 안압 하강효과

        이성훈(Sung Hoon Lee),이원석(Won Seok Lee),성공제(Gong Je Seong),변석호(Suk Ho Byeon),김성수(Sung Soo Kim),고형준(Hyoung Jun Koh),이성철(Sung Chul Lee),김민(Min Kim) 대한안과학회 2016 대한안과학회지 Vol.57 No.9

        목적: 유리체 절제술을 시행한 환자에서 무보존제 도르졸라미드-티몰롤 복합제제의 안압 하강효과 및 안구 자극증상을 보고자 하였다. 대상과 방법: 유리체절제술을 받은 뒤 안압 상승으로 무보존제 도르졸라미드-티몰롤 복합제제를 처방 받아 사용한 환자 33명을 대상으로 시력검사 및 안압검사를 하였고 점안액의 안구 자극증상에 관해서는 문진 및 세극등 검사를 통해 조사하였다. 결과: 유리체 절제술 전 점안안의 평균 안압은 13.6 ± 4.4 mmHg였고 유리체절제술 직후 평균 안압은 31.7 ± 5.4 mmHg (p<0.001)로 상승하였으며 점안액 사용 1주 후에 평균 안압이 17.2 ± 7.0 mmHg로 유의하게 낮아졌다(p<0.001). 충전체 종류 및 유무에 관계없이 모두 점안액 사용 후 안압 하강 효과가 있었으며(p<0.001), 안압이 30 mmHg 이상으로 다시 상승한 적 없었고, 추가적인 녹내장 수술이 필요한 경우도 없었다. 무보존제 도르졸라미드-티몰롤 복합제제 사용 후 불편감을 느낀 사람은 33명 중 5명(15.2%)이었으며 부작용으로 인하여 약제 사용을 중단할 정도의 소견을 보인 환자는 없었다. 결론: 무보존제 도르졸라미드-티몰롤 복합제제는 방수 생성 억제를 주 기전으로 하는 항녹내장 약제로서 충전술 없이 유리체 절제술 시행 안, 유리체 절제술 후 충전체 주입 안 모두에서 안압이 비정상적으로 상승하였을 때, 점안액만으로 충분한 안압 하강 효과가 있었고 결막 자극성이 적어 환자의 높은 순응도를 기대해 볼 수 있다. Purpose: To verify the effect of preservative-free Dorzolamide/Timolol fixed combination (PFDTC) on intraocular pressure (IOP) elevation after vitrectomy. Methods: We retrospectively reviewed medical records of 33 patients who used PFDTC after pars plana vitrectomy. All patients’ visual acuity and IOP was measured and symptoms of conjunctival irritation were investigated through survey and slit lamp examination. Results: Before vitrectomy, the mean IOP was 13.6 ± 4.4 mm Hg which was elevated to 31.7 ± 5.4 mm Hg after vitrectomy (p < 0.001) and applying eyedrop lowered the mean IOP to 17.2 ± 7.0 mm Hg (p < 0.001). Regardless of tamponade material type, all elevated IOP decreased (p < 0.001) and the IOP of all 33 eyes did not rise to over 30 mm Hg again. No additional surgery for IOP control was needed during two-month follow-up period. Of the 33 patients using PFDTC, patients who felt discomfort were five (15.2%) and no patients showed side effects severe enough to stop use of eyedrop. Conclusions: PFDTC is an anti-glaucomatic agent which can reduce the IOP by inhibiting aqueous humor production. Without need for additional surgery, the eyedrop can effectively lower elevated post-vitrectomy IOP, with expectation of good patient compliance due to low risk of conjunctival irritation.

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