Controllable Synthesis of Co-Doped Spinel LiMn2O4 Nanotubes as Cathodes for Li-Ion Batteries

Li-Xin Zhang,Yuan-Zhong Wang,Hong-Fang Jiu,Ya-Lei Wang,Yi-Xin Sun,Zhenzhong Li 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.2

Spinel Co-LiMn2O4 nanotubes have been synthesized via solid state reaction using α-MnO2 nanotubes as selftemplates. The as-prepared powders were investigated by XRD, TEM, and galvanostatic discharge/charge analysis. The optimal doping amount was confirmed by galvanostatic charge/discharge measurements. The results indicate that about 67% of initial capacity (115 mAh/g) of LiMn2O4 nanotubes can be retained after 50 cycles. For Co-LiMn2O4 nanotubes, the initial reversible capacity is 126.6 mAh/g and 100 mAh/g can be maintained after 50 cycles. The capacitance retention rate of Co-LiMn2O4 nanotubes is as high as 79%. These results indicate that the doping Co can effectively improve circle stability and electrochemical performance of LiMn2O4 nanotubes.

Characteristics of isolated lactic acid bacteria and their effects on the silage quality

Siran Wang,Xianjun Yuan,Zhihao Dong,Junfeng Li,Gang Guo,Yunfeng Bai,Junyu Zhang,Tao Shao 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.6

Objective: Four lactic acid bacteria (LAB) strains isolated from common vetch, tall fescue and perennial ryegrass on the Tibetan Plateau were characterized, and their effects on the fermentation quality of Italian ryegrass (Lolium multiflorum Lam.) silage were studied. Methods: The four isolated strains and one commercial inoculant (G, Lactobacillus plantarum MTD-1) were evaluated using the acid production ability test, morphological observation, Gram staining, physiological, biochemical and acid tolerance tests. The five LAB strains were added to Italian ryegrass for ensiling at three different temperatures (10°C, 15°C, and 25°C). Results: All isolated strains (LCG3, LTG7, I5, and LI3) could grow at 5°C to 20°C, pH 3.0 to 8.0 and NaCl (3.0%, 6.5%). Strains LCG3, LTG7, I5, and LI3 were identified as Lactobacillus plantarum, Pediococcus acidilactici, Lactobacillus paraplantarum, and Lactobacillus casei by sequencing 16S rDNA, respectively. All LAB inoculants significantly (p<0.05) increased lactic acid (LA) contents and ratios of lactic acid to acetic acid, and reduced pH and ammonia nitrogen/ total nitrogen (AN/TN) compared with uninoculated silages at various temperatures (10°C, 15°C, and 25°C). Compared to the commercial inoculant G, I5, and LI3 showed similar effects on improving the silage quality of Italian ryegrass at 10°C and 15°C, indicated by similar pH, LA content and AN/TN. Conclusion: All inoculants could improve the silage fermentation quality at various temperatures (10°C, 15°C, and 25°C). At the temperature of 10°C and 15°C, strain I5 and LI3 had similar effects with the commercial inoculant G on improving the silage quality of Italian ryegrass.

The complete mitochondrial genome of a threatened loach (Sinibotia reevesae) and its phylogeny

Yuan‑Chao Zou,Bi‑Wen Xie,Chuan‑Jie Qin,Yong‑Ming Wang,Deng‑Yue Yuan,Rui Li,Zheng‑Yong Wen 한국유전학회 2017 Genes & Genomics Vol.39 No.7

In present study, the complete mitochondrial genome of Sinibotia reevesae was first sequenced using the next-generation sequencing technology and annotated using bioinformatic tools. The circular mitochondrial genome was 16,572 bp in length, and contained 13 proteincoding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and 1 displacement loop locus. It presents a typical gene organization and order for completely sequenced cypriniformes mitogenomes. The control region could be divided into three parts included the extended termination associated sequence domain, the central conserved domain and the conserved sequence block. Interestingly, two stemloop domains were found in control region and OL region, respectively. Furthermore, phylogenetic analyses using concatenated amino acid and nucleotide sequences of the 13 protein-coding genes with two different methods (Maximum likelihood and Bayesian analysis) both highly supported the close relationship of S. reevesae and Sinibotia superciliaris, which was in line with the previous classifications based on morphological and molecular studies. These data provide useful information for a better understanding of the mitogenomic diversities and evolution in fish as well as novel genetic markers for studying population genetics and species identification.

Protective effects of vitamins C and E on dichlorodiphenyltrichloroethane-induced genotoxicity and hepatotoxicity in human liver cells

Xiao Ting Jin,Li Song,Xiang Yuan Liu,Hang Qing Li,Long Cheng,Zhuo Yu Li1,,Z. Y. Li 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.2

Dichlorodiphenoxytrichloroethane (DDT), a persistent organic pollutant and hepatotoxicant, is used to control the malaria. However, scarce information exists on relevant effective inhibitors of DDT’ toxicity. The aim of this study was to investigate protective effects of natural antioxidants vitamin C (VC) or/and vitamin E (VE) on p,pʹ-DDT-induced genotoxicity and hepatotoxicity in human liver cells. p,pʹ-DDT exposure increased levels of chromatin condensation, comet parameter, micronucleus induction and DPC coefficient of HL-7702 cells in a dose-dependent manner. Also, an increase in mRNA levels of CYP1A1 as well as CYP3A4, and a decrease in UGT along with GST were observed. Interestingly, supplementation with VC or/and VE prevented p,pʹ-DDT-caused alterations in DNA damage and phase metabolism gene expressions, and the combination of VC and VE had a more protective effect than VC or VE alone. These findings illustrated that VC or/and VE could be beneficial for the alleviation of p,pʹ-DDT-incurred toxicity in human liver cells.

다원화로 향해 가는 21세기 중국미학

주입원 중앙대학교 외국어문학연구소 1999 외국학연구 Vol.- No.3

Inhibition of α-glucosidase by 2-thiobarbituric acid: Molecular dynamics simulation integrating parabolic noncompetitive inhibition kinetics

Qin, Xiu-Yuan,Lee, Jinhyuk,Zheng, Li,Yang, Jun-Mo,Gong, Yan,Park, Yong-Doo Elsevier 2018 Process biochemistry Vol.65 No.-

<P><B>Abstract</B></P> <P>The phenomenon of α-glucosidase inhibition has attracted the attention of researchers due to its association with type 2 diabetes treatment in humans. In this study, we found that 2-thiobarbituric acid (TBA) induces complex inhibition of α-glucosidase using kinetics tests and molecular dynamics (MD) simulations. Computational MD and docking simulations demonstrate that TBA interacts with three residues on active sites of α-glucosidase such as Met69, Arg212, and His348. These biochemical tests indicate that TBA reversibly inhibits α-glucosidase in a parabolic noncompetitive manner (<I>IC</I> <SUB>50</SUB> =17.13±1.14mM; <I>K</I> <SUB>i</SUB> =13.25±0.56mM) and that this inhibition is accompanied by a biphasic kinetic process. The tertiary conformational changes were not synchronized with TBA inhibition but we observed hydrophobic disruption after inactivation at higher concentrations of TBA. Our results provide insight into the functional roles of residues located at the active sites of α-glucosidase, and we suggest that compounds similar to TBA (heterocyclic compounds) targeting the key residues of active sites are potential α-glucosidase inhibitors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 2-Thiobarbituric acid (TBA) induces complex inhibition of α-glucosidase. </LI> <LI> Computational MD simulations demonstrate that TBA interacts with Met69, Arg212, and His348. </LI> <LI> TBA reversibly inhibits α-glucosidase in a parabolic noncompetitive manner (<I>IC</I> <SUB>50</SUB> =17.13±1.14mM; <I>K</I> <SUB>i</SUB> =13.25±0.56mM). </LI> <LI> The high dose of TBA induces hydrophobic disruption after inactivation. </LI> <LI> Heterocyclic compounds targeting the key residues of active sites are potential α-glucosidase inhibitors. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Cell surface vimentin-targeted monoclonal antibody 86C increases sensitivity to temozolomide in glioma stem cells

Noh, Hyangsoon,Zhao, Qingnan,Yan, Jun,Kong, Ling-Yuan,Gabrusiewicz, Konrad,Hong, Sungguan,Xia, Xueqing,Heimberger, Amy B.,Li, Shulin Elsevier 2018 Cancer letters Vol.433 No.-

<P><B>Abstract</B></P> <P>Glioblastoma multiforme (GBM) is the most prevalent and aggressive brain tumor. The current standard therapy, which includes radiation and chemotherapy, is frequently ineffective partially because of drug resistance and poor penetration of the blood-brain barrier. Reducing resistance and increasing sensitivity to chemotherapy may improve outcomes. Glioma stem cells (GSCs) are a source of relapse and chemoresistance in GBM; sensitization of GSCs to temozoliomide (TMZ), the primary chemotherapeutic agent used to treat GBM, is therefore integral for therapeutic efficacy. We previously discovered a unique tumor-specific target, cell surface vimentin (CSV), on patient-derived GSCs. In this study, we found that the anti-CSV monoclonal antibody 86C efficiently increased GSC sensitivity to TMZ. The combination TMZ+86C induced significantly greater antitumor effects than TMZ alone in eight of 12 GSC lines. TMZ+86C–sensitive GSCs had higher CSV expression overall and faster CSV resurfacing among CSV<SUP>−</SUP> GSCs compared with TMZ+86C–resistant GSCs. Finally, TMZ+86C increased apoptosis of tumor cells and prolonged survival compared with either drug alone in GBM mouse models. The combination of TMZ+86C represents a promising strategy to reverse GSC chemoresistance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Anti-CSV monoclonal antibody 86C sensitize GSCs to TMZ treatment. </LI> <LI> GSCs with higher CSV expression are more sensitive to TMZ+86C. </LI> <LI> GSCs with higher CSV resurfacing rate among CSV<SUP>−</SUP> cells are more sensitive to TMZ+86C. </LI> <LI> TMZ+86C increased apoptosis and prolonged survival in GBM models. </LI> <LI> Tumor-specific CSV antibody 86C can efficiently target human GSCs to increase their sensitivity to TMZ. </LI> </UL> </P>

Controlled synthesis of Co₂C nanochains using cobalt laurate as precursor: Structure, growth mechanism and magnetic properties

Zhang, Yajing,Zhu, Yuan,Wang, Kangjun,Li, Da,Wang, Dongping,Ding, Fu,Meng, Dan,Wang, Xiaolei,Choi, Chuljin,Zhang, Zhidong Elsevier 2018 Journal of magnetism and magnetic materials Vol.456 No.-

<P><B>Abstract</B></P> <P>Cobalt carbides (Co<SUB>2</SUB>C and Co<SUB>3</SUB>C) nanocomposites exhibit interesting hard magnetic property, controlled synthesis of individual phase facilitates to clarify the magnetism of each, but it is difficult to obtain the single phase. We present a new approach to address this issue via a polyol refluxing process, using cobalt laurate as the precursor. The single phase Co<SUB>2</SUB>C magnetic nanochains self-assembled by nanoparticles are synthesized. The precursor is the key factor for controlling the growth kinetics of the Co<SUB>2</SUB>C nanochains. Cobalt, instead of cobalt carbides, is produced if cobalt chloride, acetate and acetylacetonate replace cobalt laurate as the precursor, respectively. The evolution of the growth process has been studied. In the formation of Co<SUB>2</SUB>C, first fcc-Co produces, then it transforms into Co<SUB>2</SUB>C by carbon diffusion process, and the produced carbon first exists in disordered state and then a small amount of them transforms into graphite. Saturation magnetization (<I>Ms</I>) of Co<SUB>2</SUB>C nanochains obtained at 300 °C for 20, 60, and 180 min are 27.1, 18.9, and 10.9 emu g<SUP>−1</SUP>, respectively. The decrease of <I>Ms</I> caused by increasing carbon content, and the carbon content are much larger than the stoichiometric ratio value of Co<SUB>2</SUB>C (9.2 wt%). The Co<SUB>2</SUB>C nanochains have mesoporous pore of 3.8 nm and the specific surface area of 48.6 m<SUP>2</SUP> g<SUP>−1</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Co<SUB>2</SUB>C magnetic nanochains are synthesized using cobalt laurate as the precursor in TEG. </LI> <LI> The precursor of cobalt laurate is the key factor for controlling the growth kinetics of Co<SUB>2</SUB>C nanochains. </LI> <LI> Ms of Co<SUB>2</SUB>C nanochains obtained at 300 °C for 20, 60, and 180 min are 27.1, 18.9, and 10.9 emu g<SUP>−1</SUP>, respectively. </LI> <LI> The decrease of Ms is caused by increasing carbon content with increasing reaction time. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>We present a new approach to obtain single phase Co<SUB>2</SUB>C nanochains by using cobalt laurate as the precursor.</P> <P>[DISPLAY OMISSION]</P>

Tunable magnetic properties of double perovskite La₂Fe_2-xCo_xO₆

Wang, Weihua,Feng, Wuwei,Yuan, Jiangyan,Pang, Ning,Zhao, Xiaoxue,Li, Meiyun,Bao, Zhidi,Zhu, Kun,Odkhuu, Dorj Elsevier 2018 PHYSICA B-CONDENSED MATTER - Vol.540 No.-

<P><B>Abstract</B></P> <P>Double perovskite La<SUB>2</SUB>Fe<SUB>2-x</SUB>Co<SUB>x</SUB>O<SUB>6</SUB> was prepared and studied. Orthorhombic and trigonal structures were obtained depend on the molar ratio of Fe to Co. Fe-rich sample demonstrate ferrimagnetic properties; with increasing content of Co, trigonal structure is favored and the net magnetic moment of sample decrease gradually to zero. Our experimental results were further supported by first-principle theoretical calculations and demonstrate that La<SUB>2</SUB>Fe<SUB>2-x</SUB>Co<SUB>x</SUB>O<SUB>6</SUB> is a new high <I>T</I> <SUB> <I>c</I> </SUB> ferromagnetic semiconductor with tunable magnetic properties and is thus a promising material for spintronics devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Phase-pure double perovskite La2Fe2-xCoxO6 was prepared. </LI> <LI> Orthorhombic and trigonal structures were obtained depending on the ratio of Fe to Co. </LI> <LI> La2Fe2-xCoxO6 is a new high Tc ferromagnetic semiconductor with tunable magnetic properties. </LI> <LI> Theoretical ab initio calculations further support our experimental results. </LI> </UL> </P>

Health Economics Evaluation of a Gastric Cancer Early Detection and Treatment Program in China

Li, Dan,Yuan, Yuan,Sun, Li-Ping,Fang, Xue,Zhou, Bao-Sen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Objective: To use health economics methodology to assess the screening program on gastric cancer in Zhuanghe, China, so as to provide the basis for health decision on expanding the program of early detection and treatment. Materials and Methods: The expense of an early detection and treatment program for gastric cancer in patients found by screening, and also costs of traditional treatment in a hospital of Zhuanghe were assessed. Three major techniques of medical economics, namely cost-effective analysis (CEA), cost-benefit analysis (CBA) and cost-utility analysis (CUA), were used to assess the screening program. Results: Results from CEA showed that investing every 25, 235 Yuan on screening program in Zhuanghe area, one gastric cancer patient could be saved. Data from CUA showed that it was cost 1, 370 Yuan per QALY saved. Results from CBA showed that: the total cost was 1,945,206 Yuan with a benefit as 8,669,709 Yuan and an CBR of 4.46. Conclusions: The early detection and treatment program of gastric cancer appears economic and society-beneficial. We suggest that it should be carry out in more high risk areas for gastric cancer.