마행의감탕의 소염.진통.해열작용

노은미,문영희,Roh, Eun-Mi,Moon, Young-Hee 한국생약학회 2001 생약학회지 Vol.32 No.3

The anti-inflammatory activity of water extract of Mahaengeuigam-Tang(MHEGTWE) was examined using the carrageenin and acetic acid induced edema, croton oil induced granuloma pouch, and adjuvant arthritis in rats. In addition, the acute toxicity, analgesic and antipyretic effects of MHEGTWE were investigated by the general experimental methods. In acute toxicity test in mice, MHEGTWE showed 10% mortality at 2400 mg/kg(p.o), but it did not showed at 1200 mg/kg(i.p). It was also showed significant analgesic action on the writhing syndrome induced by 0.7% acetic acid at 600 mg/kg(p.o) and its antipyretic activity was observed in the typhoid vaccine induced fevered rats at 300 mg/kg(p.o). By the oral administration of the MHEGTWE, the significant anti-inflammatory activity was observed on 1% carrageenin induced edema, and it significantly inhibited the granuloma and exudate formation in rats. In the adjuvant arthritis experiment, the MHEGTWE decreased the hind paw edema in rats for 19 days. The results suggest that MHEGTWE has analgesic, anti-inflammatory and antipyretic action.

Synthesis and Analgesic and Anti-inflammatory Activities of 1,2-Benzothiazine Derivatives

Lee, Eun Bang,Kwon, Soon Kyoung,Kim, Sang Geon 德成女子大學校 藥學硏究所 1999 藥學論文誌 Vol.10 No.1

Three 1,2-benzothiazine derivatives were synthesized, and their analgesic/ anti-inflammatory efficacy and their effects on gastric irritation were evaluated. Among the three compounds, 39 exhibited the most potent analgesic action, but the effect was weaker than that of piroxicam. Nonetheless, the compound showed 4 times more potent analgesic action with less gastric damage than did ibuprofen. These compounds did not show anti-inflammatory effect at an oral dose of 5 ㎎/㎏.

백두옹엑스 분획물의 소염진통작용

천선아,최병기,정춘식,이대위,이은방,Cheon, Seon-Ah,Choi, Byung-Kee,Jeong, Choon-Sik,Li, Da-Wei,Lee, Eun-Bang 한국생약학회 2000 생약학회지 Vol.31 No.2

From our previous report, the water extract of Pulsatilla koreana root was found to have potent anti-inflammatory and analgesic actions in intravenous administration in animals. Among chloroform, ethyl acetate, butanol and water fractions which were obtained through successive fractionation of the extract, only the water fraction was found to have the antiinflammatory and analgesic actions. The fraction did not affect normal body temperature at the effective doses in mice and showed low acute toxicity of which $LD_{50}$ was less than 500 mg/kg i.v. in mice. It is interesting that its anti-inflammatory action might be attributed in part to inhibition of cyclooxygenase-1 and -2.

서경탕의 소염 . 진통작용

고재종,이규종,문영희,Go, Jae-Jong,Lee, Kyu-Joung,Moon, Young-Hee 한국생약학회 2000 생약학회지 Vol.31 No.2

The anti-inflammatory activity of SEO-KYONG-TANG extract(SKTWE) was examined by using carrageenin- and acetic acid-induced edema, croton oil-induced granuloma pouch, and adjuvant arthritis in rats. In addition, the acute toxicity, analgesic and antipyretic effects of SKTWE were investigated by using general experimental methods in mice. SKTWE did not show acute toxicity at 2400 mg/kg(p.o.) nor 1200 mg/kg(i.p.). After oral administration of the SKTWE to rats, significant anti-inflammatory activity was observed on 1% carrageenin- and 5% acetic acid-induced edema. Also, it significantly inhibited granuloma and exudation in these. In the adjuvant arthritis experiment, the SKTWE decreased the hind paw edema after 3 days of oral administration. In addition, it inhibited the writhing syndromes induced by 0.7% acetic acid in mice. The antipyretic activity of SKTWE was also observed through the typhoid vaccine experiment. These results suggest that SKTWE has analgesic, anti-inflammatory and antipyretic action.

Anti-arthritic Effect of Glucosamine and Oriental Herbal Composition

Seong-Wan Cho,Young Il Kim,Young-Jae Lee,Hyoung-Kwon Cho,Young-Kwon Kim 대한의생명과학회 2008 Biomedical Science Letters Vol.14 No.2

This study was conducted to investigate the effect of an anti-inflammatory and analgesic action of the glucosamine HCl (Glucosamine) and SH-1 (Glucosamine + Oriental herbal composition combined group). Male sprague-Dawley rats (200~250 g) and ICR mice (20~30 g) were randomized and these experimental groups were divided into 4 groups. Two control group were given as negative control (saline) and positive control (Ibuprofen, 100 ㎎/㎏) and two groups given as oral administration of Glucosamine (320 m/㎏) and SH-1. Carrageenan induced paw edema test, hot plate method, croton oil induced granuloma, capillary permeability test and acetic acid writhing syndrome were also shown to be comparable in the SH-1 group to anti-inflammatory drug group such as positive control group (Ibuprofen). Although further studies should be performed to confirm the effects of SH-1, present results suggest that the combined administration of SH-1 have potential action in anti-inflammatory and analgesic action. It could be applicable for the improvement of arthritic symptoms as a new diet-supplement.

Morphine의 진통작용과 행동변화의 연관성

이성룡,김수경 啓明大學校 醫科大學 1991 계명의대학술지 Vol.10 No.1

Many studies have suggested a relationship between the analgesic action of morphine and monoaminergic systems of the brain. In this paper, the influences of morphine on the analgesic effect, locomotor activity, stereotyped behavior and rearing by alteration of brain catecholamine contents were studied in mice. Morphine (5 and 10mg/kg) significantly increased analgesic action and incresas of analgesic action was inhibited by naloxone pretreatment. Morphine significantly increased locomotor activity, stereotyped behavior (1, 5 and 10mg/kg) and rearing (5 and 10mg/kg), but were not affected by naloxone pretreatment. Apomorphine(400㎍/kg) did not significantly affect increase of analgesic action and locomotor activity, but significantly inhibited increase of the stereotyped behavior and rearing activity by morphine(10mg/kg). Reserpine(5mg/kg) slightly inhibited increase of analgesic anction but significantly inhibited the increase of locomotor activity and stereotyped behavior, and significantly increased or inhibited the change of rearing activity by morphine. These results suggest that morphine induces behavioral changes in analgesic dose and these changes are probably due to changes of catecholamine contents rather than opiate receptors in mice.

坐宮丹이 항균, 항혈전 및 진통작용에 미치는 영향

조선화,유동열,정진홍 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.4

This study was performed to evaluate antimicrobial, antithrombotic and analgesic action of Joa Goung Dan(JGD) which has been clinically used for warming lower-abdominal region and removing pathological blood component. The results were obtained as follows JGD didn't show antimicrobial action against S. aureus, E. coli, K. pneumonia, and C. albicans JGD inhibited platelet aggregation induced by collagen significantly in low concentration as compared with the control group. JGD inhibited pulmonary embolism induced by collagen and epinephrinesignificantly in only high concentration as compared with the control group. JGD increased number of platelet significantly in all concentration as compared with the control group in thrombus model induced by dextran. JGD decreased prothrombin time significantly in all concentration as compared with the control group in thrombus model induced by dextran. JGD shortened activated partial thromboplastin time insignificantly in all concentration as compared with the control group in thrombus model induced by dextran. JGD decreased fibrinogen amount insignificantly as compared with the control group in thrombus model induced by dextran. JGD did show analgesic action on the writhing syndrome induced by acetic acid From above results, JGD provide a successful therapeutic modality against symptom and sign of lower-abdominal region in woman as a medicine for external use.

구미강활탕의 소염.진통작용

고재종,박조영,문영희,Go, Jae-Jong,Park, Jo-Young,Moon, Young-Hee 한국생약학회 1999 생약학회지 Vol.30 No.1

This study was investigated on anti-inflammatory and analgesic activity on Gu-Mi-Gang-Hwal-Tang which has been used for the treatment of common cold and headache, arthralgia, fever in oriental medicine. The anti-inflammatory activities of Gu-Mi-Gang-Hwal-Tang water extract (GMGHT) on the carrageenin induced edema, acetic acid induced edema, and corton oil induced granuloma pouch in rats were examined. The analgesic effect of the GMGHT was investigated utilizing acetic acid induced writhing syndrome in mice. The antipyretic activity of the GMGHT was also investigated. The oral administration of GMGHT has been shown the anti-inflammatory activities in 1% carrageenin and acetic acid induced edema in rats. The GMGHT has been shown significant inhibitory effects on glanuloma and exudate formation in rats, especially the GMGHT (450 mg/kg) has the efficacy more than the GMGHT (150 mg/kg). The writhing syndromes induced by acetic acid in mice were inhibited, especially analgesic activity of the GMGHT (450 mg/kg) is similar to that of piroxicam and antipyretic activities were recognized in rats. In the present study, the GMGHT is indicated to have the anti-inflammatory, analgesic and antipyretic activities.

Anti-inflammatory, Analgesic and Antipyretic Activities of Loxoprofen Sodium Given Intramuscularly in Animals

Hyun, Jin Ee,Li, Da Wei,Lee, Eun Bang,Jeong, Choon Sik 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1

The evaluation of the anti-inflammatory, analgesic and antipyretic activities of loxoprofen sodium given in intramuscular route was investigated as compared to oral application in rats and mice. The intramuscular ED_50 values of loxoprofen sodium in carrageenan edema and vascular permeability tests are 1.15 and 7.8 ㎎/㎏, respectively, which represent more potent than in case of oral application. Its therapeutic effects in adjuvant arthritis were shown at 6 ㎎/㎏ i.m and 3 ㎎/㎏ p.o. Analgesic effect was shown to be more potent as given intramuscularly. Similar potency of antipyretic effects was shown in both administration routes. Considerably weak gastric damages were observed in intramuscular application.

Anti-inflammatory, Analgesic and Antipyretic Activities of Loxoprofen Sodium Given Intramuscularly in Animals

Hyun, Jin-Ee,Li, Da-Wei,Lee, Eun-Bang,Jeong, Choon-Sik The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.6

The evaluation of the anti-inflammatory analgesic and antipyretic activities of loxoprofen sodium given in intramuscular route was investigated as compared to oral application in rats and mice. The intramuscular $ED_{50}$ values of loxoprofen sodium in carrageenan edema and vascular permeability tests are 1.15 and 7.8 mg/kg, respectively, which represent more potent than in case of oral application. Its therapeutic effects in adjuvant arthritis were shown at 6 mg/kg l.m. and 3mg/kg p.o. Analgesic effect was shown to be more potent as given intramuscularly. Similar potency of antipyretic effects was shown in both administration routes. Considerably weak gastric damages were observed in intramuscular application.