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RISS 인기검색어
- 검색키워드
- 발행기관 : THE JAPANESE UROLOGICAL ASSOCIATION (검색결과 4 건)
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Body mass index influences prostate‐specific antigen in men younger than 60 years of age
Kim, Yong‐,June,Han, Byung Kuy,Hong, Sung Kyu,Byun, Seok‐,Soo,Kim, Wun‐,Jae,Lee, Sang Eun THE JAPANESE UROLOGICAL ASSOCIATION 2007 International Journal of Urology Vol. No.
<P><B>Objectives: </B> Prostate‐specific antigen (PSA) levels can be affected by many factors. Body mass index (BMI) is suspected to influence PSA levels, but the associations are controversial. The aim of this study was to examine whether PSA levels were affected by BMI and age in Koreans.</P><P><B>Methods: </B> We evaluated the association between BMI and PSA in a group of 8640 Korean men (aged 40–79 years) without prostate cancer who received a general health checkup. Eligible men were classified into age groups spanning 10 years. BMI was categorized as normal (BMI <22.9), overweight (BMI 23.0–24.9), obese (BMI 25.0–29.9), and very obese (BMI ≥30) according to the re‐defined World Health Organization (WHO) criterion for the Asia Pacific Region. PSA levels were stratified by age and BMI category.</P><P><B>Results: </B> Prostate‐specific antigen levels decreased with increasing BMI (<I>P</I> trend <0.001). However, the inverse correlations between PSA and BMI were significant only among men 40–59 years old (<I>P</I> trend <0.05, respectively). BMI showed no significant associations with PSA in 60–79 years old (<I>P</I> trend >0.05, respectively).</P><P><B>Conclusions: </B> Our study demonstrates that increased BMI is associated with decreased PSA levels only in men younger than 60 years of age. When determining whether to carry out prostate biopsy as part of early prostate cancer detection, obesity should be considered as a factor associated with reduced PSA in healthy young men (<60 years old) with marginal PSA levels.</P>
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Imaging of renal and prostate carcinoma with refractive index radiology
Yoon, Cheol Yong,Sung, Duck Je,Lee, Ju Han,Kim, Ae Ri,Oh, Chil Whan,Je, Jung Ho,Weon, Byung Mook,Seol, Seung Kwon,Pyun, Aram,Hwu, Yeukuang,Margaritondo, Giorgio,Joo, Kwan Joong,Yoon, Duck Ki THE JAPANESE UROLOGICAL ASSOCIATION 2007 International Journal of Urology Vol. No.
<P><B>Aim: </B> Having better edge enhancement and penetrating power, refractive index radiology is suitable for the imaging of weakly absorbing objects such as tissue specimens. In this study the potential of refractive index radiology was evaluated for the imaging of renal cell carcinoma (RCC) and prostate cancer (PCA).</P><P><B>Methods: </B> Specimens were cut in 3 mm and 4 µm thickness for X‐ray radiology and hematoxylin and eosin (HE) staining, respectively. Radiographic images of RCC and PCA were obtained using the synchrotron hard X‐rays from the 7B2 beam‐line of the Pohang Light Source (PLS). The imaging technique applied was phase‐contrast radiology based on the refraction enhancement mechanism. The resulting radiographic images were analyzed in correlation with those of optical microscopy.</P><P><B>Results: </B> Using unmonochromatized hard X‐rays, it was possible to obtain images with clear edge enhancement and relatively large field of view (6 cm × 6 cm). Even with overlapping signals from thick samples (more than 700‐fold thicker than microscopic images), radiographic images clearly showed histological information of organelles in normal kidney such as glomeruli, tubules, and collecting ducts. Histological information of RCC including tumor subtypes and minute changes such as cystic degeneration could be identified without difficulty. The radiographic images of the prostate were comparable with those of low magnification optical microscopy, providing good visualization of normal microstructures such as adenoma, smooth muscle, and normal glands, or differentiation of tiny tumors from surrounding normal tissues.</P><P><B>Conclusions: </B> These results suggest the potential of refractive index radiology to provide a new way of imaging biological tissues with low absorption contrast such as RCC and PCA.</P>
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Park, Eun‐,Ah,Lee, Hak Jong,Kim, Kwang Gi,Kim, Seung Hyup,Lee, Sang Eun,Choe, Ghee Young THE JAPANESE UROLOGICAL ASSOCIATION 2007 International Journal of Urology Vol. No.
<P><B>Objective: </B> To identify the most reliable predictor of the pathological stage among multiple parameters obtained by performing systematic biopsies and to assess the predictive value of any identified parameters in combination with the prostate specific antigen and the Gleason scores.</P><P><B>Methods: </B> We examined 5 biopsy parameters from 12 systematic needle biopsy results in 104 consecutive prostate cancer patients who underwent prostatectomy: the number of cores positive for cancer, percentage of positive biopsy cores, total linear cancer length (absolute sum of tumor length at each core), percentage cancer length (total cancer length divided by total length of cores obtained ×100), and maximum cancer core length. The predictive values of these parameters were assessed using multivariate logistic analysis and receiver operating characteristic analysis. We evaluated whether the most reliable biopsy parameter in combination with traditional variables show better predictability of the pathological stage than traditional variables alone by receiver operating characteristic analysis.</P><P><B>Results: </B> Of 104 patients, 85 (82.9%) had organ confined cancer and 19 (17.1%) showed extraprostatic extension. Of the five parameters examined, maximum cancer length was found to best predict pathological staging. Although insignificant, adding results of maximum cancer length to prostate specific antigen and Gleason scores improved predictability. Of 41 patients with a maximum cancer length of <0.9 cm, PSA of <16 ng/mL, and Gleason score of <7, none showed extraprostatic extension.</P><P><B>Conclusions: </B> The maximum cancer length was found to be the most reliable predictor of disease staging. The findings of a maximum cancer length of <0.9 cm, PSA of <16 ng/mL, and a Gleason score of <7 can suggest an organ‐confined disease.</P>
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CHANG, SUNG‐,GOO,KIM, CHUL‐,SOO,JEON, SEUNG HYUN,KIM, YOUN‐,WHA,CHOI, BO YOUL THE JAPANESE UROLOGICAL ASSOCIATION 2006 International Journal of Urology Vol. No.
<P><B>Aim: </B> To evaluate the cause of elevated prostate‐specific antigen (PSA) in patients with transrectal needle biopsy negative for prostate cancer.</P><P><B>Methods: </B> Serum PSA concentration, prostate volume, and pathologic findings were examined in 223 patients with negative biopsy for prostate cancer. The degree of prostate inflammation was determined by the extent and degree of inflammation shown by biopsy specimens and is expressed as an inflammation score (range: 0–36).</P><P><B>Results: </B> A significant correlation was found between PSA concentration and prostate total volume (<I>P</I> = 0.0001). Prostate chronic inflammation showed no correlation with PSA concentration (<I>P</I> = 0.485, F = 0.488). After allocating patients to normal PSA (≤4 ng/mL) and high PSA (>4 ng/mL) groups, we found that serum PSA concentrations in both groups were predominantly affected by prostate total volume.</P><P><B>Conclusions: </B> An increase in prostate volume appears to be the major contributor to a high serum PSA concentration in patients with negative biopsy for prostate cancer. However, in contrast to previous reports, there was no correlation between the degree of prostate chronic inflammation and serum PSA concentrations.</P>
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