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Marcia de Oliveira Franco,Edenio Detmann,Sebastiao de Campos Valadares Filho,Erick Darlisson Batista,Luana Marta de Almeida Rufino,Marcilia Medrado Barbosa,Alexandre Ribeiro Lopes 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.6
Objective: Effects of nitrogen supplementation associated with different levels of starch on voluntary intake, digestibility, and rumen and metabolic characteristics of cattle fed low-quality tropical forage (Brachiaria decumbens hay, 7.4% crude protein, CP) were evaluated using ruminal and abomasal cannulated steers. Methods: Five European×Zebu young bulls (186 kg body weight, BW) were distributed according to a 5×5 Latin square. The following treatments were evaluated: control, supplementation with 300 g CP/d (0:1), supplementation with 300 g starch/d and 300 g CP/d (1:1), supplementation with 600 g starch/d and 300 g CP/d (2:1), and supplementation with 900 g starch/d and 300 g CP/d (3:1). A mixture of nitrogenous compounds provided 1/3 from true protein (casein) and 2/3 from non-protein nitrogen (mixture of urea and ammonium sulphate, 9:1) was used as the nitrogen supplement. In order to supply energy a unique source of corn starch was used. Results: Supplements increased (p<0.05) dry matter intake, but did not affect (p>0.05) forage intake. There was a cubic effect (p<0.05) of starch on voluntary intake. This was attributed to the highest forage intake (g/kg BW) when using the 2:1 starch:CP ratio. Supplements increased (p<0.05) organic matter (OM) digestibility, but did not affect (p>0.05) neutral detergent fibre corrected for ash and protein (NDFap) digestibility. There was a positive linear effect (p<0.05) of the amount of starch supplemented on OM digestibility. Total NDFap digestibility was not affected (p>0.05) by the amount of supplemental starch. Ruminal ammonia nitrogen concentrations were higher (p<0.05) in supplemented animals, however, a negative linear effect (p<0.05) of amount of starch was observed. Supplements increased (p<0.05) the nitrogen balance (NB) and efficiency of nitrogen utilization. These effects were attributed to increased body anabolism, supported by higher (p<0.05) serum concentration of insulin-like growth factor 1. Increasing the amount of starch tended (p<0.06) to linearly increase the NB. In spite of this, there was a highest NB value for the 2:1 starch:CP ratio amongst the treatments with supplementation. Conclusion: Nitrogen supplementation in cattle fed low-quality tropical forage increases nitrogen retention in the animal’s body. An additional supply of starch increases nitrogen retention by increasing energy availability for both rumen and animal metabolism.
Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes
Bruna Oliveira de Almeida,João Agostinho Machado-Neto 생화학분자생물학회 2020 BMB Reports Vol.53 No.8
ANKHD1 (ankyrin repeat and KH domain containing 1) is a large protein characterized by the presence of multiple ankyrin repeats and a K-homology domain. Ankyrin repeat domains consist of widely existing protein motifs in nature, they mediate protein-protein interactions and regulate fundamental biological processes, while the KH domain binds to RNA or ssDNA and is associated with transcriptional and translational regulation. In recent years, studies containing relevant information on ANKHD1 in cancer biology and its clinical relevance, as well as the increasing complexity of signaling networks in which this protein acts, have been reported. Among the signaling pathways of interest in oncology regulated by ANKHD1 are Hippo signaling, JAK/STAT, and STMN1. The scope of the present review is to survey the current knowledge and highlight future perspectives for ANKHD1 in the malignant phenotype of cancer cells, exploring biological, functional, and clinical reports of this protein in cancer.
Luciana de Almeida Vittori Gouveia,Carolina Alves Cardoso,Glaucia Maria Moraes de Oliveira,Glorimar Rosa,Annie Seixas Bello Moreira 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.4
This study is aimed at assessing the scientific evidence on the effect of the intake of sesame seeds and derivatives on oxidative stress of individuals with systemic hypertension, dyslipidemia, and type 2 diabetes mellitus. A systematic review was conducted in seven databases (Lilacs, PubMed, ISI Web of Knowledge, Cochrane Library, Scopus, Trip Database, and Scielo) from September 2013 to January 2014. Clinical trials on the intake of sesame seeds and derivatives assessing the outcomes related to oxidative stress were retrieved. The risk of bias in the results of the studies selected was assessed according to the criteria of the Cochrane Handbook for Systematic Reviews of Interventions. This review included seven clinical trials showing that the intake of sesame resulted in the increase in enzymatic and nonenzymatic antioxidants, as well as in a reduction in oxidative stress markers. This was mainly observed with the use of sesame oil for hypertensive individuals during 2 months and black sesame meal capsules for prehypertensive individuals during four weeks. Most studies involved a small number of participants, sample size being considered a limiting factor for this review. In addition, a significant heterogeneity was observed in the type of population studied and the type of sesame and derivatives used, as well as their amount. The follow-up time was considered a limiting factor, because it varied in the different studies. The high risk of randomization and blinding biases found in the studies assessed determines lower scientific evidence of the results. Despite the limitations and biases identified in this systematic review, sesame showed relevant effects on oxidative stress, suggesting it could increase the antioxidant capacity.
Cristiane Urcina Joanna Oliveira Lima,Cláudio Olavo de Almeida Cordova,Otávio de Tolêdo Nóbrega,Silvana Schwerz Funghetto,Margô Gomes de Oliveira Karnikowski 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1
There has been a significant increase in the use of mushrooms for therapeutic and medicinal purposes, in particular, use of the species Agaricus blazei Murrill, a basidiomycota of Brazilian origin. The objective of this study was to identify scientific evidence regarding the influence of A. blazei Murrill on the immune system. We undertook an integrative review of indexed publications published between 2000 and 2009, using the following question as a guideline: “What evidence can be found in the literature regarding the influence of A. blazei Murrill on the immune system?” Fourteen studies verified that there is in vitro and in vivo research demonstrating this mushroom's influence on the immune system. All research was characterized as evidence level 7 (preclinical study [animals/in vitro]). The research shows that A. blazei Murrill functions through bioactive compounds via mechanisms that are not yet entirely clear, although it has been shown that they promote action on the innate and adaptive immunological response, activation of the complement system, and synthesis of pro- and anti-inflammatory cytokines and even aid in diapedesis. Despite broad scientific evidence demonstrating relevant immunomodulatory properties of A. blazei Murrill, randomized clinical trials with human subjects are still needed in order for the mushroom to be put into clinical practice.
Anderson Junger Teodoro,Carolina de Oliveira Ramos Petra de Almeida,Raquel Martins Martinez,Vanessa Rosse de Souza,Thuane Passos Barbosa Lima,Bruna Almeida Nascimento,Gabriel de Alcantara Noblat,Giova 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.1
This study evaluates the effects of supplementation of murici (Byrsonima crassifolia) and tapereba´ (Spondiasmombin) pulp extracts on dietary intake, body composition, biochemical parameters, and markers of oxidative stress. Twoexperiments were conducted with a total of 80 healthy male Wistar rats and a 30-day supplementation. In the first experiment,animals were divided into control (C) group, murici group 50 mg/(kg$day) (50Mu), murici group 100 mg/(kg$day) (100Mu),and murici group 200 mg/(kg$day) (200Mu). In the second experiment, animals were divided into C group, tapereba´ group50 mg/(kg$day) (50Tap), tapereba´ group 100 mg/(kg$day) (100Tap), and tapereba´ group 200 mg/(kg$day) (200Tap). Resultsshowed lower feed intake in 50Mu, 100Mu, and 100Tap groups (13%, 12%, and 10%, respectively, P < .05) and lower bodyfat in 200Mu, 100Tap, and 200Tap groups (16.0%, 29.1%, and 27.1%, respectively, P < .05). Only the 100Tap group showedreduced adipose tissue content (30.4%; P < .05). Increased plasma antioxidant capacity was observed at all doses for bothfruits. Tapereba´ supplementation reduced ferrous oxidation–xylenol orange levels (50Tap: 8.4%, 100Tap: 16.1%, 200Tap:24.3%; P < .05) and increased thiol levels (50Tap: 39%, 100Tap: 31%; P < .05). Serum thiobarbituric acid reactive substanceslevels were reduced in all groups receiving tapereba´ (50Tap: 77.7%, 100Tap: 73.1%, 200Tap: 73.8%; P < .05) and murici(50Mu: 44.5%, 100Mu: 34%, 200Mu: 43%; P < .05). Therefore, it is suggested that the inclusion of these fruits in the diet cancontribute to health maintenance and disease prevention, through their effects on controlling food intake, improving bodycomposition, and in combating oxidative stress.
Bruno Augusto Alves Martins,Marcelo de Melo Andrade Coura,Romulo Medeiros de Almeida,Natascha Mourão Moreira,João Batista de Sousa,Paulo Gonçalves de Oliveira 대한대장항문학회 2017 Annals of Coloproctolgy Vol.33 No.3
Transanal endoscopic microsurgery is considered a safe, appropriate, and minimally invasive approach, and complications after endoscopic microsurgery are rare. We report a case of sepsis and pneumoretroperitoneum after resection of a rectal lateral spreading tumor. The patient presented with rectal mucous discharge. Colonoscopy revealed a rectal lateral spreading tumor. The patient underwent an endoscopic transanal resection of the lesion. He presented with sepsis of the abdominal focus, and imaging tests revealed pneumoretroperitoneum. A new surgical intervention was performed with a loop colostomy. Despite the existence of other reports on pneumoretroperitoneum after transanal endoscopic microsurgery, what draws attention to this case is the association with sepsis.
Ozana Almeida Lessa,Nadabe dos Santos Reis,Selma Gomes Ferreira Leite,Melissa Limoeiro Estrada Gutarra,Alexilda Oliveira Souza,Simone Andrade Gualberto,Julieta Rangel de Oliveira,Elizama Aguiar-Olivei 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.1
During cocoa (Theobroma cacao L.) processing, the accumulated cocoa shell can be used for bioconversion to obtain valuable compounds. Here, we evaluate the effect of solid-state fermentation of cacao flour with Penicillium roqueforti on secondary metabolite composition, phenol, carotenoid, anthocyanin, flavonol, and fatty acids contents, and antioxidant activity. We found that the total concentrations of anthocyanins and flavonols did not change significantly after fermentation and the phenolic compound and total carotenoid concentrations were higher. The fermentation process produced an increase in saponin concentration and antioxidant activity, as well as significant changes in the levels of oleic, linoleic, gamma-linolenic, and saturated fatty acids. Based on our findings, we propose that the reuse of food residues through solid state fermentation is viable and useful.
Control and Reorganization of Heterogeneous Vehicle Platoons after Vehicle Exits and Entrances
Daniel Almeida Godinho,Armando Alves Neto,Leonardo Amaral Mozelli,Fernando de Oliveira Souza 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8
Platoons are efficient solutions to improve road transportation, traffic throughput, and other demands. But problems such as environmental disturbances, network imperfections, and unaware surrounding vehicles increase the necessity for resilient methods that ensure stability and connectivity among the platoon members. Hence, in this paper, we study the problem of decentralized control for platoons of heterogeneous vehicles under a limited communication range with a constant spacing policy. The goals are to guarantee inter-vehicle distances in steady-state, and resourcefulness to overcome entrances and exits of vehicles. Our main result is a resilient strategy, composed of a reconfiguration protocol and some simple rules for tuning the control law, based on local information about the relative connectivity to neighbors. It guarantees, in a decentralized manner, the automatic reorganization of the platoon under the entry and exit of agents. We conclude by illustrating our approach with simulated experiments on platoons with different numbers of vehicles, and by comparing it with the current state-of-the-art.