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RISS 인기검색어
- 검색키워드
- 저자 : Zulfiqar Ali Bhat (검색결과 4 건)
- 무료
- 기관 내 무료
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Preliminary pharmacognostical and phytochemical evaluation of Stachys tibetica Vatke
Zulfiqar Ali Bhat,Dinesh Kumar,Vijender Kumar,Ishtaq Ahmad Chashoo,Nisar Ahmad Khan,Irfat Ara,Mohammad Yassin Shah 셀메드 세포교정의약학회 2012 TANG Vol.2 No.1
Stachys tibetica Vatke (Lamiaceae) is an important medicinal plant in the folk medicine of Ladakh, India and Tibet for the treatment of various mental disorders. Infusion and decoction of the whole plant is used as a cup of tea for a severe fever, headaches and to relieve tension. The recent study is aimed to evaluate the preliminary pharmacognostical and phytochemical nature of Stachys tibetica Vatke. The whole plant material was subjected to successive soxhlet extraction with petroleum ether (40 - 60C), chloroform, ethyl acetate, methanol and finally decocted with water to get the respective extracts. The fluorescence characteristics of the powdered materials were analysed under ultraviolet light and ordinary light. Different physicochemical parameters such as ash value, extractive value, foaming index, pH values, loss on drying and determination of foreign matter were carried out as per WHO guidelines. The total fat, flavonoid, saponin and volatile contents were also determined. Macroscopical studies revealed the authentication of the plant drug. Physicochemical parameters helped to standardize the plant material while preliminary qualitative chemical tests of different extracts showed the presence of Glycosides, Carbohydrates, Phytosterols/triterpenoids, Saponins, Fixed oils, Fats and phenols/tannins. Quantification of the total flavonoids and saponins and contents were determined as 54.66 ± 0.58 mg/g and 75.42 ± 0.48 mg/kg respectively, while the volatile and fat contents were 6.5% and 0.7% respectively. Results may lay the foundation for the standardization of the drug and discovery of new molecules from S. tibetica for the treatment of various diseases.
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Effect of successive extracts of Stachys tibetica Vatke (Lamiaceae) in anxiety
Kumar, Dinesh,Bhat, Zulfiqar Ali,Shah, M.Y. 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.4
Stachys tibetica Vatke (Lamiaceae) is an important medicinal plant in the folk medicine of Ladakh, India and Tibet for the treatment of various mental disorders. Infusion and decoction of the whole plant is used as a cup of tea in severe fever, headache and to relieve tension. Present study is aimed to evaluate the anxiolytic effect of successive extracts of Stachys tibetica Vatke (SES). Stachys tibetica Vatke (1 kg) was subjected to successive extraction in a soxhlet apparatus with different solvents of increasing polarity like petroleum ether ($40-60^{\circ}C$), chloroform, ethyl acetate, methanol and finally decocted with water (yield 7.08 %, 3.98 %, 2.02 %, 16.40 % and 21.53 % w/w respectively). All successive extracts were subjected to phytochemical screening. Rutin was identified by TLC method in the extracts. SES were evaluated for anxiolytic activity using elevated plus maze and light/dark arena tests in rats. Phytochemical studies showed the presence of flavonoids, terpenoids, saponins, glycosides, tannins, alkaloids etc. which might be responsible for anxiolytic activity. TLC analysis of the extracts also showed the presence of flavonoids (rutin). SES increased number of entries and time spent in open arms on the elevated plus maze test while as in the light/dark arena test; they showed an increase in number of crossings and time spent in light arena. The results of both the models of anti-anxiety studies were reflected on the 1st, 3rd and 7th day. Methanol and aqueous showed the most, chloroform and petroleum ether ($40-60^{\circ}C$) intermediate and ethyl acetate the least anxiolytic activity ($^*P$ <0.05, $^{**}P$ <0.01, $^{***}P$ <0.001) in both the models. The results strongly justify the use of this plant for treatment of anxiety. Further studies are in progress in our laboratory to isolate and identify the components responsible for anxiolytic activity and the mechanism of action involved.
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Anti allergic and anti-inflammatory effects of the fruits of Randia dumetorum Lamk
Dinesh kumar,Satish C. Mudgade,Zulfiqar Ali Bhat,Santosh S. Bhujbal,R. Rub,이철훈,손은화 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3
Randia dumetorum Lamk. commonly known as Madana in Sanskrit and widely distributed throughout India. In Ayurveda, Randia dumetorum Lamk. is used in treatment asthma, rhinitis, bronchatitis, cold, cough, pain,inflammation etc. The aim of this study: was to assess the anti allergic effects of the fruit of Randia dumetorum Lamk. Allergy and anaphylaxis are the most responsible factor for diseases like asthma, rhinitis, bronchatitis, cold,cough, pain, inflammation etc. Asthma is an inflammatory disease of lungs and the hallmarks of the disease are the increased inflammatory cell infiltration into the airways and poor respiratory function although there is a possibility that Randia dumetorum Lamk. may have an inhibitory effect on lung inflammation and allergic mediators. The effects of Randia dumetorum Lamk. on allergy and asthma have not been fully investigated. In the present study, we investigated the antiallergic and antiinflammatory activity of Randia dumetorum Lamk. extract and its fraction on milk induced leucocytosis and eosinophilia in mice, passive paw anaphylaxis and mast cell degranulation in rat models. Randia dumetorum Lamk. extract was obtained from dried and powdered fruits of Randia dumetorum Lamk. using 95% methanol and its fractions were obtained by using increasing polarity of solvents like Petroleum ether, chloroform,ethylacetate and methanol. Milk was used to induce leucocytosis and eosinophilia in mice model, eggalbumin was used as sensitizer in passive paw anaphylaxis in rat model and clonidine was used to degranulate the mast cells in rat model. We examined the effects of Randia dumetorum Lamk. extract and its fraction on milk induced leucocytosis and eosinophilia in mice, passive paw anaphylaxis and mast cell degranulation in rats. The extract and its fractions significantly inhibited leukocytosis and eosinophilia in blood of mice. The extract and its fractions also significantly inhibited the passive paw oedema and mast cell degranulation in rats. Methanol extract showed dose dependent significant activity (**p<0.01). Amongst the fractions, chloroform fraction showed the most significant activity followed by ethyl acetate and residual methanol fraction with intermediate activity and finally the petroleum ether fraction with the least or negligible activity (*p<0.05, **p<0.01). These results suggest the possibility of extract and its fraction can exert suppressive effects on allergy, inflammation and asthma and may provide evidence that Randia dumetorum Lamk. is a useful agent for the treatment of allergic airway disease. Hence it would be a good path for the isolation of most bioactive principle for the management of allergic airway disease.
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