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Peng Zhou,Haichun Ma,Jingping Wang,Jiazhong Qian 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.5
The engineering water inrush events were affected by the hydraulic characteristics of the fractures. In order to quantitatively study the seepage characteristics of the fractures, the experimental analysis of artificial fracture of shale was carried out under different confining pressure (22 MPa − 38 MPa) to explore the influence of confining pressure on seepage characteristics. Three theoretical constitutive formulas to describe the characteristics of seepage were proposed based on cubic law and fracture constitutive equation (Bandis model, Rong model, Sun model), and these theoretical constitutive formulas all had good fitting results to experiment results which indicated that the derived formulas are feasible. The parameters for the three models were compared, among which the Rong model was more suitable to describe the connection between (Q) and (Pc). Rong model and Sun model were highly descriptive to the relationship between (Pc) and (Ps). The formulas that based on three theoretical models can provide quantitative calculation for the influence of in-situ stress change on the seepage of fractures in engineering practice.
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Reconfigurable Flight Control System Design for Blended Wing Body UAV Based on Control Allocation
Xiaobo Qu,Jingping Shi,Haijun Zhou,Ling Zuo,Yongxi Lyu 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10
The aircraft control surface fault reconfigurable scheme based on control allocation is an active approach to achieve fault-tolerant in flight control. It has obvious advantages such as the structure and parameters of the control law does not need to be redesigned as deflector failures occurs. The attainable moment subset and allocation efficiency with typical control allocation algorithms are evaluated. A modular scheme reconfigurable flight control system (FCS) of a miniature tailless Blended Wing Body UAV is studied by utilizing weighted pseudo-inverse, direct control, and fixed-point control allocation methods. The performance of the reconfigurable FCS is tested and verified with the simulation including typical failure modes such as deflector floating, loss-of-effectiveness and lock-in-place. Results validate that the reconfigurable FCS based on control allocation has preferable ability to handle deflector failures, improve the safety and reliability of aircraft. And the modular scheme proposed in the article demonstrates a good application prospect in the field of aviation and aerospace engineering.
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Zhang Shaolong,Zhou Jingping,Shang Pengzhao,Zhao Guomeng,Wang Anlei,Mao Jinlei,Tao Yuhang,Chen Ziyi,Wang Xuehao,Guo Changying 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Tumor-associated macrophages (TAMs) are one of the main cellular components in the tumor microenvironment (TME). In many types of solid tumors, TAMs tend to accumulate in hypoxic areas and are intimately related to poor patient prognosis. However, the underlying mechanisms by which TAMs infiltrate hypoxic tumor regions remain unclear. In this study, we report that genetic deletion of SE translocation (SET) in myeloid cells inhibited the entry of TAMs into the hypoxic tumor region and abated their proangiogenic and immunosuppressive functions, ultimately inhibiting tumor growth. Mechanistically, in response to hypoxic tumor supernatant stimulation, SET in macrophages shuttled between the nucleus and cytoplasm via the PKC-CK2α signaling axis. Cytoplasmic retention of SET increased ERK and P38 signaling by inhibiting PP2A, which promoted TAM migration into the hypoxic area and polarization toward the M2 phenotype. Therefore, we conclude that SET modulates tumor immunity by acting as a key regulator of macrophage positioning and function in the tumor.
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