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- 저자 : Zhifeng Ning (검색결과 3 건)
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Ning Xu,Aimin Wu,Fuming Li,Hao Lin,Jiada Wu,Peinan Wang,Yuancheng Du,Zhifeng Ying 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.32
CNx nanocrystals and nanotubes were synthesized on Co/Ni-covered Si(100) wafers using a nitrogen-atom-beam-assisted pulsed laser ablation deposition method. Transimission electron microscopy, X-ray photoelectron spectroscopy and Raman spectroscopy showed that nanometer-sized CNx nanocrystals and nanotubes were contained in the as-deposited lms. The co-catalyzation by the cobalt and nickel in the synthesis process is considered to play an important role in the formation of CNx nanocrystals and nanotubes. The reasons for the formation of CNx nanocrystals and nanotubes have been analyzed.
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Wang Yan,Wen Jun,Zheng Jiangyun,Deng Zhifeng,Zhou Yueyu,Jiang Guisheng,Xia Qiangsheng,He Enjie,Ning Lixin 한국물리학회 2021 Current Applied Physics Vol.26 No.-
Thermodynamic properties, electronic structures and spectroscopic properties of defects and Ce3+ in Y2O3 are studied by using the hybrid density functional theory associated with multi-reference configuration interaction ab-initio calculations. Thermodynamic transition energy levels of the easily generated oxygen vacancies in the host are analyzed according to HSE06-calculated formation energies, which may be conducive to interpretations of the persistent luminescence (PersL) of Y2O3-based phosphors. Besides, the locations of impurity states (caused by VO and Ce3+) in energy bands are obtained from derived density of states. Moreover, energies and oscillator strengths of 4f1 → 5d1 5 transitions of Ce3+ ions (at Y1 and Y2 sites) calculated from the CASSCF/CASPT2/ RASSI SO method agree reasonably well with experimental excitation spectra of Y2O3: Ce3+ phosphors, achieving the assignment of excitation spectra. The presented calculations can be applied to identify luminescent centers in Ce3+-doped phosphors and reveals possible native defects and their roles in the PersL of phosphors.
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Banghua Wang,Jia Shen,Zexia Wang,Jian-Xia Liu,Zhifeng Ning,Meichun Hu 한국유방암학회 2018 Journal of breast cancer Vol.21 No.1
Purpose: Vascular endothelial growth factor (VEGF) signal transduction mainly depends on its binding to VEGF receptor 2 (VEGFR-2). VEGF downstream signaling proteins mediate several of its effects in cancer progression, including those on tumor growth, metastasis, and blood vessel formation. The activation of VEGFR-2 signaling is a hallmark of and is considered a therapeutic target for breast cancer. Here, we report a study of the regulation of the VEGFR-2 signaling pathway by a small molecule, isomangiferin. Methods: A human breast cancer xenograft mouse model was used to investigate the efficacy of isomangiferin in vivo. The inhibitory effect of isomangiferin on breast cancer cells and the underlying mechanism were examined in vitro. Results: Isomangiferin suppressed tumor growth in xenografts. In vitro, isomangiferin treatment inhibited cancer cell proliferation, migration, invasion, and adhesion. The effect of isomangiferin on breast cancer growth was well coordinated with its suppression of angiogenesis. A rat aortic ring assay revealed that isomangiferin significantly inhibited blood vessel formation during VEGF-induced microvessel sprouting. Furthermore, isomangiferin treatment inhibited VEGF-induced proliferation of human umbilical vein endothelial cells and the formation of capillary-like structures. Mechanistically, isomangiferin induced caspase-dependent apoptosis of breast cancer cells. Furthermore, VEGFinduced activation of the VEGFR-2 kinase pathway was downregulated by isomangiferin. Conclusion: Our findings demonstrate that isomangiferin exerts anti-breast cancer effects via the functional inhibition of VEGFR-2. Pharmaceutically targeting VEGFR-2 by isomangiferin could be an effective therapeutic strategy for breast cancer.
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