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Wen-Hsuan Tseng,Wei-Chung Hsu,Tsung-Lin Yang,Tzu-Yu Hsiao,Jia-Feng Wu,Hui-Chuan Lee,Hsiu-Po Wang,Ming-Shiang Wu,Ming-Shiang Wu,Ping-Huei Tseng 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.3
Background/AimsLaryngeal symptoms are largely treated with empiric proton pump inhibitor (PPI) therapy if no apparent pathology shown on ear, nose, and throat evaluation and reflux-related etiologies are suspected. However, treatment response remains unsatisfactory. This study aimed to investigate the clinical and physiological characteristics of patients with PPI-refractory laryngeal symptoms. MethodsPatients with persistent laryngeal symptoms despite PPI treatment for ≥ 8 weeks were recruited. A multidisciplinary evaluation comprising validated questionnaires for laryngeal symptoms (reflux symptom index [RSI]), gastroesophageal reflux disease symptoms, psychological comorbidity (5-item brief symptom rating scale [BSRS-5]) and sleep disturbance (Pittsburgh sleep quality index [PSQI]), esophagogastroduodenoscopy, ambulatory impedance-pH monitoring, and high-resolution impedance manometry were performed. Healthy asymptomatic individuals were also recruited for comparison of psychological morbidity and sleep disturbances. ResultsNinety-seven adult patients and 48 healthy volunteers were analyzed. The patients had markedly higher prevalence of psychological distress (52.6% vs 2.1%, P < 0.001) and sleep disturbance (82.5% vs 37.5%, P < 0.001) than the healthy volunteers. There were significant correlations between RSI and BSRS-5 scores, and between RSI and PSQI scores (r = 0.26, P = 0.010, and r = 0.29, P = 0.004, respectively). Fifty-eight patients had concurrent gastroesophageal reflux disease symptoms. They had more prominent sleep disturbances (89.7% vs 71.8%, P < 0.001) than those with laryngeal symptoms alone but similar reflux profiles and esophageal motility. ConclusionsPPI-refractory laryngeal symptoms are mostly associated with psychological comorbidities and sleep disturbances. Recognition of these psychosocial comorbidities may help optimize management in these patients.
Li-Fei Wang,Panca Oktawirani,Bo-Kang Liou,Yih-Mon Jaw,Yu-Hsiu Tseng 한국관광연구학회 2019 관광연구저널 Vol.33 No.4
To probe a Muslim-friendly regulation which may be more implementable than the original Halal standards in Taiwan, this study tried to explore Muslims’ bottom line of acceptance for different dietary cultures when they are exposed to a place where Islam is not the main religion. In view of geographic position and population size, Indonesian Muslims are the most important Muslim customers for Taiwanese market, so this study focused on Indonesian Muslims’ dietary situations in Taiwan. A questionnaire survey was conducted and 233 adequate responses were collected from 3 groups of Indonesian Muslims in Taiwan. The results showed that most of the long/medium-period Indonesian Muslim residents prefer preparing their daily foods to taking the foods supplied by their employers or school canteens. General markets are their major shopping places for foods/food raw materials without special taboos. Multiple choices from 19 categories of foods revealed that they are not used to the Western-style foods. Statistical analyses on the acceptability of the 13 non-Halal scenarios indicated that Indonesian Muslims do not expect the foods/restaurants of 100% Halal qualified in Taiwan. As long as “no pork and no alcohol” can be assured by the credible institutes, many Taiwanese foods and restaurants can be well accepted by the Indonesian Muslims.