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Clinical Characteristics of Post-COVID-19 Persistent Cough in the Omicron Era
Kang Yu Ri,Huh Jin-Young,Oh Ji-Yoon,Lee Ji-Hyang,Lee Daegeun,Kwon Hyouk-Soo,Kim Tae-Bum,Choi Jae Chol,Cho You Sook,Chung Kian Fan,Park So-Young,Song Woo-Jung 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.3
Cough is one of the most common symptoms of acute coronavirus disease 2019, but cough may persist for weeks or months. This study aimed to examine the clinical characteristics of patients with post-coronavirus disease (COVID) persistent cough in the Omicron era. We conducted a pooled analysis comparing 3 different groups: 1) a prospective cohort of post-COVID cough (> 3 weeks; n = 55), 2) a retrospective cohort of post-COVID cough (> 3 weeks; n = 66), and 3) a prospective cohort of non-COVID chronic cough (CC) (> 8 weeks; n = 100). Cough and health status was assessed using patient-reported outcomes (PROs). Outcomes, including PROs and systemic symptoms, were longitudinally evaluated in the prospective post-COVID cough registry participants receiving usual care. A total of 121 patients with post-COVID cough and 100 with non-COVID CC were studied. Baseline cough-specific PRO scores did not significantly differ between post-COVID cough and non-COVID CC groups. There were no significant differences in chest imaging abnormality or lung function between groups. However, the proportions of patients with fractional exhaled nitric oxide (FeNO) ≥ 25 ppb were 44.7% in those with post-COVID cough and 22.7% in those with non-COVID CC, which were significantly different. In longitudinal assessment of the post-COVID registry (n = 43), cough-specific PROs, such as cough severity or Leicester Cough Questionnaire (LCQ) scores, significantly improved between visits 1 and 2 (visit interval: median 35 [interquartile range, IQR: 23–58] days). In the LCQ score, 83.3% of the patients showed improvement (change ≥ +1.3), but 7.1% had worsened (≤ −1.3). The number of systemic symptoms was median 4 (IQR: 2–7) at visit 1 but decreased to median 2 (IQR: 0–4) at visit 2. In summary, post-COVID persistent cough was similar in overall clinical characteristics to CC. Current cough guideline-based approaches may be effective in most patients with post-COVID cough. Measurement of FeNO levels may also be useful for cough management.
Kang, Yu Ri,Byun, Jun Seok,Kim, Tae Jung,Park, Han Gyeol,Park, Jae Chan,Barange, Nilesh,Nam, Koo Hyun,Kim, Young Dong American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.6
<P>The epidermal growth factor receptor (EGFR) protein has received significant attention in medical biotechnology because it is an important component in cell growth and division. We report the results of a study on the binding between the EGFR protein and the associated aptamer, measured in real time. Aptamers can be used for clinical purposes including macromolecular medicine and basic research. In particular, EGFR aptamers are promising molecular agents for targeting cancer. The data were obtained in-situ with total internal reflection ellipsometry (TIRE), which combines the analytic capability of spectroscopic ellipsometry with the high surface sensitivity of surface plasmon resonance measurements. Our results show that TIRE can be used to determine adsorption of nanoscale biomolecules. Our results are supported by additional data obtained by liquid atomic-force-microscopy.</P>
Kang, Min Ah,Kyu Sik Yoon,Hye Ri Kwon,Min Woo Park,Shin Hyuk Jo,Shin Hyo Seob,Sae Hee Kim,Eun Jin Kang,Mi Ja Seo,Yong Man Yu,Young Nam Youn 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10
Pyrifluquinazon, as a quinazinalone chemical group, based on a new mode of biological activity. It is reported that mode of action is modifies insect behavior, rapidly stopping feeding such that insects starve to death. Time-release feature and mortality effect on M. persicae using different pyrifluquinazon nano type and non-nano type were compared. Pyrifluquinazon nano type was formulated with different molecular weight and density of used chitosan (CS 30000 0.1% and CS 3000 0.3%). In the CS 30,000 0.1%, the mortality was weakly occurred at early time, but steadily increased after 4days. Finally, we confirmed more than 70% mortality as a peak at 16days. In CS 3000 0.3%, the mortality showed about 70% until 18days as a effective controlled release. Also, We examine time-release feature and mortality effect on M. persicae according to the different pyrifluquinazon nano type(CS 30000 0.1% and CS 3000 0.3%) of concentrations. The CS 30000 0.1% bioassay results of different concentration were showed that the highest concentration(100ppm) was measured better mortality than other concentration at 0 day, but cannot confirm different effect about dissimilar concentration. However, increasing rates of M. persicae were low as treatment concentrate was high. In CS 3000 0.3% 100ppm concentration bioassay result, aphid mortality reached peak at 24 days and increasing rate also low. Additionally, for the comparing of bioassay and feeding behavior of M. persicae against pyrifluquinazon nano types and non-nano type, EPG technique was carried out. In case of non nano type, feeding inhibition efficacy was showed during 4 days after treatment, but appeared similar level with control after 10days. In CS 3000 0.3% 50ppm, residual efficacy was specially showed until 28days after treatment whereas treatments with CS 30000 0.1% were similar to the control after 22days. These result show that the change of feedinng behavior and motrality of M. persicae is correlated with the change of nano type or non nano type of pyrifluquinazon.
( Yu Ri Kang ),( Yong Hoon Kim ),( Ki Hyun Seo ),( Jae Sung Choi ),( Ho Sung Lee ),( Jiwon Lyu ),( Ji Hye Lee ),( Ju Ock Na ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Bronchodilator response (BDR) is sometimes observed in patients with bronchiectasis but reports on the relations between BDR and clinical characteristics and prognosis of bronchiectasis are few. The aims of our study are to compare clinical characteristics and lung function and prognosis between group with BDR and without BDR in bronchiectasis. Methods Data were collected from the Korean Multicenter Bronchiectasis Audit and Research Collaboration (KMBARC) registry, a protocol for a multicenter observational cohort study on non-cystic fibrosis bronchiectasis in Korea. Among this total 1003 patients registry, we reviewed the medical records of 355 patients who underwent baseline spirometry and 1-year follow up spirometry. Significant BDR was defined as FEV1 or FVC improvement from pre-bronchodilator value by at least 200 mL and 12% or significant pulmonary function improvement which increase at least 12% and 200 mL in FEV1 or FVC at the point of 1-year follow-up spirometry. Results Among 355 patients, total sixty-nine patients (19.4%) had BDR on PFT. Among 69 patients with BDR, 24 patients (34%) had asthma history by doctor clinically and 45 patients (66%) did not. Patients with BDR used ICS plus LABA more frequently than patients without BDR (30.4% vs 18.1%, p=0.03). Patients with BDR showed worse pulmonary function compared with no BDR patients on baseline spirometry (FEV1%, 54.3% vs 62.4%) and also in 1-year follow up spirometry. Patients with BDR showed higher risk of emergency room visit (30.4% vs 17.8% p=0.03) and hospital admission (27.8% vs 15.3%, p=0.006) compared with no BDR patients. FACED score (FEV1% predicted, age, chronic colonization by Pseudomonas aeruginosa, radiological extent of the disease, and dyspnea) were high in patients with BDR (2.1 vs 2.6, p value 0.009) . Conclusion Significant BDR in bronchiectasis patients is associated with worse pulmonary function, more frequent ER visit and hospital admission and low FACED score.
cDNA Library Construction of Aphis gossypii Using Gateway Cloning System
Hye-Ri Kwon,Jung-Kyu Kim,Na-Yeon Ko,Yu-Bin Jung,Chan-yeong Kang,Tae-Hee Ryu,Mi-Ja Seo,Hyoun-Sub Lim,Yong-Man Yu,Young-Nam Youn 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.10
Aphis gossypii was widely distributed throughout the tropical, subtropical and temperate zone. The chemical control of A. gossypii is becoming problem because it was rapidly appeared resistance expression to chemicals. We will attempt to resolve the this problem using RNAi technique. Besides, RNAi technology can be helpful to study the target genes of A. gossypii. In this study we produce cDNA library construction using gateway cloning system for selecting target gene in order to control of A. gossypii using RNAi. As a result, the 100-400bp of insert size, which is appropriate for RNAi was confirmed. Most of insert gene is associated with A. gossypii, after that insert sequence was compared with DNA databases and EST databases using NCBI blast search. Consequentially, A. gossypii of cDNA library with the titer of 3.15x105 clones were completed. And we will perform the LR recombination to transfer cDNA library into TRV2 (tobacco rattle virus) vector with att site. Then, after performing transformation using Agrobacterium tumefaciens (GV 2260), we inoculated to cucumber with A. tumefaciens. An insecticidal effect or a repellent activity against A. gossypii by changing behavior in transgenic cucumber plants were conformed. Also, the selecting target gene in order to control A. gossypii using RNAi may be provided.
강유리(Yu Ri Kang),이상훈(Sang Hoon Lee),김현영(Hyun Young Kim),우관식(Koan Sik Woo),황인국(In Guk Hwang),황영(Young Hwang),유선미(Seon Mi Yoo),김행란(Haeng Ran Kim),김혜영(Hae Young Kim),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.9
건조방법에 따른 품종별 고춧가루의 물리적 특성을 알아보기 위하여 집단밀도, 압축특성, 쌓임각, 비회복성 일 및 응력이완 특성을 살펴보았다. 이완집단밀도는 0.4197~0.4274g/cm3 범위로 열풍건조 한반도품종이 큰 밀도를, 청양품종 열풍건조가 작은 밀도를 나타내었다. 충격집단밀도는 0.523~0.586 g/cm3 범위로 원적외선건조 한반도 품종이 큰 밀도를 나타내었고 한반도품종 천일건조가 0.523 g/cm3로 작았다. 하우스너 비는 1.225~1.370의 범위를 보였으며, 두 품종 모두 원적외선 건조에서 큰 값을 나타내었다. 압축성은 0.00157~0.00225 범위로 한반도품종 원적외선건조가 큰 압축성을 나타내었다. 압축비는 0.971~1.032의 범위로 열풍건조가 크게 나타났으며, 품종에 따라서는 한반도품종이 큰 값을 나타내었다. 안식각은 37.47~42.38o 범위로 열풍건조가 큰 값을 나타내었으며, 비회복성 일은 76.0~81.7%의 범위로 건조방법에 따른 차이는 작았지만 한반도품종이 청양품종에 비해 큰 값을 보였다. k2값은 1.20~1.24 범위로 건조방법 및 품종 간 차이는 작았으며, 이완성은 13.41~24.31%범위로 원적외선 건조가 큰 값을 보였고 건조방법별로 청양 품종이 큰 값을 나타내었다. This study investigated the bulk properties of red pepper powders according to drying method and variety. Bulk density, compressive characteristics, irrecoverable work, dynamic angle, and stress relaxation were investigated. Loose bulk density ranged between 0.420 g/cm3 for Cheongyang cultivar and 0.427 g/cm3 for Hanbando cultivar by hot-air drying. The highest tapped bulk density was 0.586 g/cm3 for Hanbando cultivar by far-infrared drying and the lowest value was 0.523 g/cm3 for Hanbando cultivar by sun drying. Hausner ratio reached a maximum value of 1.370 for Hanbando cultivar by far-infrared drying. Compressibility ranged between 0.0016 for Cheongyang cultivar by sun drying and 0.0023 for Hanbando cultivar by far-infrared drying. Compression ratio reached a maximum value of 1.032 for Hanbando cultivar by hot-air drying. Dynamic angle of repose ranged between 37.47 and 42.97o. Irrecoverable work ranged between 76.0 and 81.7%. Relaxation reached a maximum value of 24.31% for Cheongyang cultivar by far-infrared drying.