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한국인 정신분열증 환자와 6번 염색체 D6S274(6p23) 다형성의 연합
김길숙,이영호,양병환,한진희,김인,오동열,곽상곤,최재영,엄상화,Kim, Gil-Sook,Lee, Young-Ho,Yang, Byung-Hwan,Han, Jin-Hee,Kim, Leen,Oh, Dong-Yul,Kwak, Sang-Kon,Choi, Jae-Young,Yrm, Sang-Hwa 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2
An association study with korean schizophrenic patients(N=75) and normal controls(N=87) was performed to find the relationship between D6S274 polymorphism and schizophrenia using polymerase chain reaction. Nine different alleles of a dinucleotide polymorphism on D6S273 locus were observed in both group. When we compared the frequencies of alleles between schizophrenics and normal controls, there was no significant difference between two groups. To increase homogeneity of schizophrenic group, we divided schizophrenic group by clinical phenotypes such as DSM-IV diagnostic subtype, family history, negative and positive symptoms(PANSS), soft neurologic signs(NES-K). Then we compared the frequencies of alleles among subgroups of clinical phenotypes. there was only significant difference between two subgroups on soft neurologic signs(p<0.05). Although our findings fail to provide on evidence of association between schizophrenia and D6S274 locus, follow-up investigation of this locus may be needed in homogeneous subtypes of schizophrenia and schizophrenic pedigrees.