방사성 면역측정상의 혈청 FSH와 LH에 관한 일차성 무월경증 환자의 진단적 고찰

유형식,이종태,박창윤,유경자,홍인수,김귀언 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.1

일차성 무월경증을 주소로 하는 환자 16명을 대상으로 혈청 FSH와 LH의 단독측정치와 최종 진단과의 관계 그리고 차후검사로는 어떤 검사가 필요한지를 조사하였던 바 다음과 같은 결론을 얻었다. 1) 혈청 FSH와 LH가 모두 증가된 경우는 5명으로 모두 난소의 일차적 병변블 보였으며 효과적 차후검사로는 구강점막 도말검사, 염색체검사, 복강경검사 및 부인과계검사 등이 필요하였다. 2) 혈청 FSH와 LH가 모두 정상인 경우는 9명으로 이중 4명은 말단 장기 즉 자궁이나 경부의 발생이상을 보였으며 5명은 원인이 불분명한 경우로 차후검사로는 환자내진, 복강경검사, 부인과계검사 및 자궁난관조영술이 필요하였다. 3) 혈청 FSH가 감소되고 LH가 정상 또는 감소를 보인 경우는 2명으로 1명은 FSH단독결핍을 보였으며 1명은 원인이 불분명한 경우로 효과적인 차후 검사로는 뇌하수체분비능검사와 두부 X-선 검사 및 LH-RH 자극시험이 필요하였다. 또한 일차성 무월경증 환자에 있어서 방사성면역측정을 이용한 혈청 FSH와 LH의 단독측정치로는 어떤 특정 원인을 진단할 수는 없었으나 주된 병변을 의심할 수는 있었고 또한 확진하기 위한 차후검사의 선택을 효과적이고 유용하게 함으로 단독측정치의 유용성이 있음을 알 수 있었다. The usefulness of single, random measurements of serum FSH and LH in the diagnosis of Primary amenorrhea by radioimnnunoassay was investigated. The 16 patients were divided into 3 groups by the level of serum FSH and LH. The first group with increased level of serum FSH and LH is five patients, all of these are related to the acquired or congenital abnormality of the ovary. Further studies indicated include buccal smear, chromosome analysis, gynecography and laparosocopy. The second group with normal serum FSH and LH is nine patients, four patients of these are related to the developmental anomaly of the Mullerian duct and five patients are undetermined origin. Further studies indicated include laparoscopy and gynecography. The third group with decreased serum FSH and normal or decreased serum LH is two patients, one of these is related to the pituitary function, isolated FSH deficiency, the other is undetermined origin. Further studies indicated include the pituitary function test, LH-RH stimulation test, skull radiography. Determination of serum FSH and LH levels does not permit a specific etiologic diagnosis of primary amenorrhea. However the serum levels of FSH and LH can be used to differentiate the principal area of the investigation and can be of assistance in choosing more specific testing procedures. $quot;

성장홀몬과 내분비계 질환

박창윤,최규옥,김기황,허갑범,유경자,이혜리,손희영 대한핵의학회 1979 핵의학 분자영상 Vol.13 No.1

1976년 1월부터 1979년 3월까지 연세대학교 부속 세브란스병원에 내원하여 뇌하수체 기능부전이 의심되어 성장홀몬의 분비능을 관찰하기 위해 L-Dopa 자극시험을 실행했던 35명과 L-Dopa 자극시험과 포도당 부가반응을 관찰하였던 4예의 달단비대증 환자를 연구 검토하여 다음과 같은 결과를 얻었다. 1) 각종 질환에서 성장홀몬의 기저치는 Sheehan씨 증후군에서는 평균치는 대조군보다 낮으나 통계적으로 유의한 차이는 없었고 당뇨병 환자에서도 평균치는 높으나 통계적으로 유의한 차이는 아니었다. 말단비대증 환자 4예 모두 대조군보다 현저한 증가를 보여주었다. 2) 당뇨병 환자 13명종 9명은 당뇨병성 망막증이 합병되었던 환자였고 이중 6명에서 L-Dopa 자극에 성장홀몬의 분비항진을 보여주었다. 망막증이 없었던 4명 중 1명에서만 분비 항진을 보여주었다. 3) Sheehan씨 증후군 10예중 L-Dopa에 분비항진을 보여준 경우는 2예였다. 4) 뇌하수체 혐염기성선종 8예중 L-Dopa 자극반응에 분비항진을 관찰한 수 있었던 것은 1예였다. 5) 4명의 말단비대증 환자중 3명은 호산성 선공이였고 1명은 혐염기성 선종이였다. 이중 3명에서 L-Dopa 자극시험을 행하였는데 1명은 그 측정치가 80 ng/ml 이상이어 반응 판정이 불가능했고 2명은 L-Dopa에 paradoxical response를 보여주었다. 포도당 부가검사를 시행한 2명 모두에서 포도당 투여후 억제반응을 보여주었다. 6) 두개인두종 2예중 1예에서 L-Dopa 자극반응을 보여주었 저신장(short statas)는 2예중 1예에서 L-Dopa 자극후 분비 항진을 보여주었다. This is an analysis of 39 patients studied at the Yonsei Medical Center from January, 1976 to March 1979. Of these 35 patient were suspected of having hypothalamic insufficiency and subjected to the L-Dopa stimulation test to observe growth hormone sceretory function while four acromegaly patient received the glucose loading test and L-Dopa stimulation test. The results are as follows: 1) The basal level of GH in the various disease was as follows: a) The basal level was lower than the control level but was not statisfically significant b) In diabetes the mean value tended to higher than the control level but was not significant statistically c) In all four acromegaly patients the GH level was significantly higher than the control level 2) Of 13 patients with diabetes, nine had diabetic retinopathy, and of those nine, six showed increased L-Dopa response. However, of the four non retinopathic DM patients, onl one showed increased response to L-Dopa. 3) Two patients out of ten with Sheehan's syndrome responded to L-Dopa stimulation. 4) One Patient of eight prith pituitary chromophobe adenoma responded to L-Dopa stimulation. 5) Four acromegaly patients revealed 3 acidophilic adenoma and one chromophobe adenoma histologically. Of patients receiving the L-Dopa stimulation test. Two showed a paradoxical response. Two patients who received the glucose loading test showed supressed response. 6) Of two craniopharyngioma patients, one showed increased GH response after L-Dopa stimulation. Increased response of GH after L-Dopa stimulation was seen in one two craniopharyngioma patients and also in one of two patients with short statasture.

시상하부 - 뇌하수체 질환에 있어서 뇌하수체의 TSH 분비능에 관한 연구

최규옥,김선용,박창운,허갑범,유경자 대한핵의학회 1979 핵의학 분자영상 Vol.13 No.1

1977년 4월부터 1979녈 1월까지 연세대학교 의과대학 부속 세브란스 병원에 입원하였던 시상하부-뇌하수체 질환 환자 27예를 대상으로 TRH 자극시험과 안의 용적을 측정하고, 관계를 조사 연구하여 다음과 같은 결론을 얻었다. 1) Sheehan씨 증후군 12예에서 TRH 자극에 대한 TSH 분비 반응이 모두 나타나지 않았다. 2) 말단비대증을 동반한 뇌하수체종양에서 TSH 분비 반응은 정상이었다. 3) 혈염기성선종 4예에서는 2예는 반응을 나타나지 않았다. 안의 용적이 심하게 커지고 상안으로 파급된 예에서는 갑상선기능저하를 보이면서 TSH 반응은 나타났다. 4) 두개인두종 3예중 2예에서 반응을 나타내지 않았는데 이중 1예에서 갑상선 기능저하와 안내로 파급된 것으로 나타났다. 5) 안의 용적과 TSH 반응관계는 뇌하수체 종양과 두 개인두종의 각각 1예에서 있었다. 6) 요붕증 환자 3예에서 모두 반응이 나타나지 않았다. 7) 일차성 무월경증 3예중 1예에서 반응을 나타낸 것은, FSH의 단독 결핍에 의한 것으로 나타났다. The TRH stimulation test was known as a highly diagnostic method in hypothalamopituitary disorders. To evaluate the location and the extension of the lesion, we estimated TSH response to TRH test in 27 patients. Correlation between volume of sella and TSH response was also studied. The results obtained were 25 follows: 1) In Sheehan's syndrome, TSH response after TRH test were not observed in all of 12 patients. 2) All 2 acromegaly patients showed normal TSH response. 3) In 4 cases of chromophobe adenoma, 2 cases showed no TSH response. In 2 responded cases, one patient whose tumor mass extended to suprasella region was hypothyroid state. 4) In craniopharyingioma 3 cases, the tumor which extended to intrasella showed hypothyroid and no TSH response. 5) Correlation between volume of sella and TSH response were valuable in 2 cases, but no diagnostic significance. 6) In diabetes inspidus, TSH response were all absent. 7) In primary amenorrhea, TSH response observed in 1 case, which conformed with isolated FSH deficiency.

Interrelatedness of Fe composition on structural and magnetic properties in Fe-doped SrRuO3 thin films

Yoo, Y. Z.,Chmaissem, O.,Kolesnik, S.,Brown, D. E.,Dabrowski, B.,Kimball, C. W.,Kim, T.-W.,Kim, M.-S.,Genis, A. P.,Song, J.-H. Springer-Verlag 2014 APPLIED PHYSICS A MATERIALS SCIENCE AND PROCESSING Vol.115 No.3

Measurement of Hard X-Rays on KSTAR

Yoo, J. W.,Lee, Y. S.,England, A. C.,Chen, Z. Y.,Kim, W. C.,Oh, Y. K.,Kwon, M. Informa UK (TaylorFrancis) 2011 Fusion science and technology Vol.60 No.t1

High control rate for lymph nodes in cervical cancer treated with high-dose radiotherapy using helical tomotherapy.

Kim, Y J,Kim, J Y,Yoo, S H,Min, B J,Chung, K Z,Seo, S S,Kang, S B,Lim, M C,Hwang, J H,Yoo, H J,Park, S Y Adenine Press 2013 Technology in cancer research & treatment Vol.12 No.1

<P>The purpose of this study was to evaluate whether bulky lymphadenopathy located in the abdominopelvic cavity in cervical cancer can be controlled without severe toxicity by increasing radiation dose using helical tomotherapy. From January 2007 to December 2010, 26 patients with cervical cancer with metastatic lymph nodes (LNs) having at least one short diameter > 1.5?cm were treated with helical tomotherapy. A total of 58 LN sites were treated and the largest LN of each site was evaluated for response. Median follow-up time was 28 months (4-50 months). Median short diameter of the LNs was 1.7?cm (0.7-4.2?cm) with median radiation dose of 62.6?Gy(10) in 2?Gy equivalent dose (53.3-77.9?Gy(10)). Initial LN response was evaluated on imaging obtained within 4 months after radiotherapy. Initial complete response (CR), partial response (PR), and stable disease (SD) were observed in 54, 2 and 2 lesions, respectively. Recurrence occurred in two with CR and progression in one with PR. Therefore, final CR, PR, SD, and progression of disease were observed in 52, 1, 2, and 3, respectively. Actuarial 3-year LN progression-free survival and overall survival (OS) were 63% and 65%, respectively. Multivariate analysis revealed final LN response (CR vs. non-CR) as a strong prognostic factor for OS (p =?0.016). Radiation Therapy Oncology Group grade 2 or more acute and late toxicity was observed in 8 and 1 patients, respectively. The treatment of bulky lymphadenopathy using helical tomotherapy in advanced cervical cancer is highly effective and has acceptable toxicity.</P>

당뇨병 및 신부전에서의 폐투과성에 관한 연구

유진목(Z . M . Yoo),안태훈(T . H . Ahn),인광호(K . H . In),조재연(J . Y . Cho),강경호(K . H . Kang),유세화(S . H . Yoo) 대한내과학회 1989 대한내과학회지 Vol.36 No.2

N/A To evaluate the changes of alveolar epithelial permeability in chronic renal failure (CRF) and diabetes mellitus (DM), we studied the index of alveolar permeability in 9 normal controis, 9 CRF patients under regular hemodialysis treatment and 15 DM patients. The half time clearance from lung to blood (tl/2LB) of radioactivities was calculated by a technetium labelled diethylene triamine pentaacetic acid ( 99mTc- DTPA) radioaerosol inhalation scan. The tl/2LB was not different between the control group (RUL 47.44±6. 61 min, RLL 51.44±6.61 min) and CRF group (RUL 43.72±9.80 min, RLL 45.35±7.26 min). The tl/2 did not differ between the control group and DM group with (RUL 56.01±16.80 min, RLL 49.00±19.23 min) or without (RUI. 54.B4±8.33 min, RLL 56.77±7.80 min) retinopathy. These results suggest that alveolar epithelial permeability is not significantly inceased in CRF patients under regular hemodialysis, and it is al salso not changed in DM patilents, irrespective of the presence of diabetic retinopathy.

Development of a Compact Diagnostic System for Monitoring Hard X-Rays

Lee, Y.S.,Nam, U.W.,England, A.C.,Chen, Z.Y.,Yoo, J.W.,Kim, W.C.,Oh, Y.K. AMERICAN NUCLEAR SOCIETY, INC. 2011 Fusion science and technology Vol.60 No.2

A Lactate-Induced Response to Hypoxia

Lee, D.,Sohn, H.,Park, Z.Y.,Oh, S.,Kang, Y.,Lee, K.m.,Kang, M.,Jang, Y.,Yang, S.J.,Hong, Y.,Noh, H.,Kim, J.A.,Kim, D.,Bae, K.H.,Kim, D.,Chung, Sang J.,Yoo, H.,Yu, D.Y.,Park, K.,Yeom, Y. Cell Press ; MIT Press 2015 Cell Vol.161 No.3

Organisms must be able to respond to low oxygen in a number of homeostatic and pathological contexts. Regulation of hypoxic responses via the hypoxia-inducible factor (HIF) is well established, but evidence indicates that other, HIF-independent mechanisms are also involved. Here, we report a hypoxic response that depends on the accumulation of lactate, a metabolite whose production increases in hypoxic conditions. We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normoxia but is protected from destruction by binding to lactate that accumulates under hypoxia. The stabilized NDRG3 protein binds c-Raf to mediate hypoxia-induced activation of Raf-ERK pathway, promoting angiogenesis and cell growth. Inhibiting cellular lactate production abolishes the NDRG3-mediated hypoxia responses. Our study, therefore, elucidates the molecular basis for lactate-induced hypoxia signaling, which can be exploited for the development of therapies targeting hypoxia-induced diseases.

先天性心臟疾患의 臨床的 觀察 : 277例 報告

鄭英姬,郭景魯,李每子,李謹洙,柳會性 대한의학협회 1968 대한의학협회지 Vol.11 No.2