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Mutational analysis of KRAS and its clinical implications in cervical cancer patients
Wei Jiang,Libing Xiang,Xuan Pei,Tiancong He,Xuxia Shen,Xiaohua Wu,Huijuan Yang 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.1
Objective: The predictive and prognostic role of KRAS mutations in cervical cancer remainsinconclusive. The aim of this study was to explore the clinicopathological and prognosticrelevance of KRAS mutations in invasive cervical cancers (ICC). Methods: Reverse transcription polymerase chain reaction (PCR) and Sanger sequencingwere employed to detect KRAS mutations in 876 ICC patients. Quantitative real-time PCR wasused to detect human papillomavirus (HPV) 16 and HPV 18. Results: Non-synonymous mutations of KRAS were identified in 30 (3.4%) patients. Thesemutations were more common in non-squamous cell carcinoma than in squamous cellcarcinoma (SCC) (8.2% vs. 2.2%, respectively, p<0.001) and were associated with HPV 18infection (p=0.003). The prevalence of mutations was highest (18.2%) in the uncommonhistological subtypes followed by adenocarcinoma (AC, 7.3%) and adenosquamouscarcinoma (ASC, 5.8%). During the median follow-up of 55 months, compared to patientswith wild-type KRAS, a greater percentage of patients with mutant KRAS relapsed (20.0%vs. 42.9%, respectively, p=0.007). The 3-year relapse-free survival was poorer in patientswith mutant KRAS than in patients without KRAS mutations (57.1% vs. 81.9%, respectively,p=0.001). Furthermore, the multivariate analysis showed that the presence of a KRASmutation was an independent predictor for disease recurrence (hazard ratio [HR]=2.064;95% confidence interval [CI]=1.125–3.787; p=0.019). Conclusion: KRAS mutations were predominant in non-SCCs of the cervix and wereassociated with HPV 18 infection. A combination of KRAS mutation detection andHPV genotyping would be useful in identifying patient with poor prognosis for furtherinterventions.
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Modeling and Analysis of an Avionic Battery Discharge Regulator
Chen, Qian,Yu, Haihong,Huang, Xiaoming,Lu, Yi,Qiu, Peng,Tong, Kai,Xuan, Jiazhuo,Xu, Feng,Xuan, Xiaohua,Huang, Weibo,Zhang, Yajing The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.3
The avionic battery discharge regulator (BDR) plays an important role in a power-conditioning unit. With its merits of high efficiency, stable transfer function, and continuous input and output currents, the non-isolated Weinberg converter (NIWC) is suitable for avionic BDR. An improved peak current control strategy is proposed to achieve high current-sharing accuracy. Current and voltage regulators are designed based on a small signal model of a three-module NIWC system. The system with the designed regulators operates stably under any condition and achieves excellent transient response and current-sharing accuracy.
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Modeling and Analysis of an Avionic Battery Discharge Regulator
Qian Chen,Haihong Yu,Xiaoming Huang,Yi Lu,Peng Qiu,Kai Tong,Jiazhuo Xuan,Feng Xu,Xiaohua Xuan,Weibo Huang,Yajing Zhang 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.3
The avionic battery discharge regulator (BDR) plays an important role in a power-conditioning unit. With its merits of high efficiency, stable transfer function, and continuous input and output currents, the non-isolated Weinberg converter (NIWC) is suitable for avionic BDR. An improved peak current control strategy is proposed to achieve high current-sharing accuracy. Current and voltage regulators are designed based on a small signal model of a three-module NIWC system. The system with the designed regulators operates stably under any condition and achieves excellent transient response and current-sharing accuracy.
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