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RISS 인기검색어
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- 저자 : Xiao-Ran Ma (검색결과 4 건)
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Xiao-Ran Ma,Li Zhang,You-Rong Li 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.4
In order to understand the onset of Rayleigh-Bénard convection of cold water near its density maximum in a vertical annular container heated from below and cooled from above, the instability of the static diffusive state was investigated by linear stability analysis. Two kinds of thermal boundary conditions, perfect insulating and conducting sidewalls, were used. The aspect ratio and radius ratio of the annular container varied from 0.5 to 4.5 and 0.1 to 0.8, respectively. Results indicate that the critical Rayleigh number and the critical wave number increase with the increase of density inversion parameter. There are some new flow modes with large azimuthal wave number near the convection onset for cold water with density maximum, which are not observed in Rayleigh-Bénard convection of the Boussinesq fluids. The stratified flow phenomenon in cold water with density maximum is certified. The larger the density inversion parameter is, the more obvious the stratified flow phenomenon becomes. With the increase of the aspect ratio, the critical Rayleigh number decreases, but the critical wave number increases. However, with the increase of the radius ratio, both the critical Rayleigh number and the critical wave number increase continuously. Furthermore, the effect of thermal boundary conditions at the sidewalls on the convection stability is also validated.
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Xiao-Ran Li,En-Bo Ma,Liang-Zhen Yan,Han Meng,Xiao-Wei Du,Zhe-Xue Quan 한국미생물학회 2013 The journal of microbiology Vol.51 No.4
Fermented foods and beverages are important parts of human diet. Fen liquor, a Chinese liquor is a fermented beverage that uses a traditional fermentation process. Starters are the main microbial source and also provide nutrients for microorganisms during fermentation. In this study, starters of Fen liquor were produced through a complex traditional fermentation process. To investigate the community structure and the composition of microorganisms in the starter production process, bacterial 16S rRNA and fungal internal transcribed spacer (ITS) regions were sequenced using clone libraries and pyrosequencing, respectively. There was much higher diversity among the bacteria than among the fungi in the starter production process. Bacteria on the surface of the starters belonged mostly to the Lactobacillaceae family,while members of the Bacillacae family were dominant in the interior of the samples that lacked access to air and water. In the fungi population, diversity was high only in the raw material. In all other samples, nearly all of the fungal sequences were from Pichia kudriavzevii, a member of the Saccharomycetaceae family. Nearly all samples showed similar fungal community structures, indicating that there was little change in the fungal community. To the best of our knowledge, this is the first report to reveal the whole process of the starter production of Chinese traditional liquor. The findings obtained in this study provide new insights into understanding the composition of the microbial community during the traditional Chinese liquor starter production process and information about the production process control and monitoring.
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Zhouxuan Xiao,Licheng Ma,Wan Jiang,Ran Wang,Yuyan Yao,Jie Cai,Jingyu Lin,Lu Li 한국지질과학협의회 2020 Geosciences Journal Vol.24 No.3
Detailed petrologic, geochemical and geochronological investigation on migmatites provide key information on the tectonic-magmatic history of the Quanji Massif, NW China. The studied migmatites are mainly composed of granitic gneisses, with lenticular refractory residua spread along its foliation. Zircon U-Pb ages of 1129.2 ± 7.4 Ma (1σ, MSWD = 0.34, N = 31) and 1135.1 ± 9.5 Ma (1σ, MSWD = 0.05, N = 22) were determined for the granitic gneiss and refractory residue, respectively. Garnet grains from the refractory residue show no distinctive intra-crystalline zonation, and are rich in Fe and Mg, but poor in Ca and Mn, akin to those from metapelite. Samples from the granitic gneisses have high contents of SiO2 (from 67.92% to 69.89%), K2O (from 3.94% to 5.00%) and A/CNK (1.11–1.17), with LREE enrichment and distinctly negative Eu anomalies (Eu/Eu* = 0.49–0.53) in the chondrite-normalized REE patterns, and significantly negative Nb, Ta, Ti and Sr anomalies in the primitive mantle-normalized spider diagrams. Granitic gneisses samples have consistent Nd isotope compositions with negative εNd(t) values ranging from –1.06 to –6.04, and TDM model ages ranging from 1.83 to 2.23 Ga. These geochemical features suggest that the granitic rocks belong to the S-type granites, which were predominately derived from a late Paleoproterozoic crustal source. The granitic gneiss was probably formed by partial melting of the sediments which had been suffered graunlite-facies metamorphism. The components with low melting points (e.g., felsic minerals) might replace the sediments to form migmatites and migmatitic granites, and thus preserved the refractory residua. Therefore, the late Mesoproterozoic orogenic event is the coeval response of the global Grenvillian orogeny, indicating an important crustal remelting episode in the Quanji Massif.
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Zhou Meng-jiao,Yang Jia-jie,Ma Ting-yao,Feng Ge-xuan,Wang Xue-lian,Wang Li-Yong,Ge Yu-ze,Gao Ran,Hong-liang Liu,Shan Lin,Kong Lu,Chen Xiao-hong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
MYB-NFIB fusion and NOTCH1 mutation are common hallmark genetic events in salivary gland adenoid cystic carcinoma (SACC). However, abnormal expression of MYB and NOTCH1 is also observed in patients without MYB-NFIB fusion and NOTCH1 mutation. Here, we explore in-depth the molecular mechanisms of lung metastasis through single-cell RNA sequencing (scRNA-seq) and exome target capture sequencing in two SACC patients without MYB-NFIB fusion and NOTCH1 mutation. Twenty-five types of cells in primary and metastatic tissues were identified via Seurat clustering and categorized into four main stages ranging from near-normal to cancer-based on the abundance of each cell cluster in normal tissue. In this context, we identified the Notch signaling pathway enrichment in almost all cancer cells; RNA velocity, trajectory, and sub-clustering analyses were performed to deeply investigate cancer progenitor-like cell clusters in primary tumor-associated lung metastases, and signature genes of progenitor-like cells were enriched in the “MYC_TARGETS_V2” gene set. In vitro, we detected the NICD1-MYB-MYC complex by co-immunoprecipitation (Co-IP) and incidentally identified retinoic acid (RA) as an endogenous antagonist of genes in the “MYC_TARGETS_V2” gene set. Following this, we confirmed that all-trans retinoic acid (ATRA) suppresses the lung metastasis of SACC by correcting erroneous cell differentiation mainly caused by aberrant NOTCH1 or MYB expression. Bioinformatic, RNA-seq, and immunohistochemical (IHC) analyses of primary tissues and metastatic lung tissues from patients with SACC suggested that RA system insufficiency partially promotes lung metastasis. These findings imply the value of the RA system in diagnosis and treatment.
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