Transcriptome profiling of rubber tree (Hevea brasiliensis) discovers candidate regulators of the cold stress respo

Xiao‑Xiao Gong,Bing‑Yu Yan,Jin Hu,Cui‑Ping Yang,Yi‑Jian Li,Jin‑Ping Liu,Wen‑Bin Liao 한국유전학회 2018 Genes & Genomics Vol.40 No.11

Tropical plant rubber tree (Hevea brasiliensis) is the sole source of commercial natural rubber and low-temperature stress is the most important limiting factor for its cultivation. To characterize the gene expression profiles of H. brasiliensis under the cold stress and discover the key cold stress-induced genes. Three cDNA libraries, CT (control), LT2 (cold treatment at 4 °C for 2 h) and LT24 (cold treatment at 4 °C for 24 h) were constructed for RNA sequencing (RNA-Seq) and gene expression profiling. Quantitative real time PCR (qRT-PCR) was conducted to validate the RNA-Seq and gene differentially expression results. A total of 1457 and 2328 differentially expressed genes (DEGs) in LT2 and LT24 compared with CT were respectively detected. Most significantly enriched KEGG pathways included flavonoid biosynthesis, phenylpropanoid biosynthesis, plant hormone signal transduction, cutin, suberine and wax biosynthesis, Pentose and glucuronate interconversions, phenylalanine metabolism and starch and sucrose metabolism. A total of 239 transcription factors (TFs) were differentially expressed following 2 h or/and 24 h of cold treatment. Cold-response transcription factor families included ARR-B, B3, BES1, bHLH, C2H, CO-like, Dof, ERF, FAR1, G2-like, GRAS, GRF, HD-ZIP, HSF, LBD, MIKC-MADS, M-type MADS, MYB, MYB-related, NAC, RAV, SRS, TALE, TCP, Trihelix, WOX, WRKY, YABBY and ZF-HD. The genome-wide transcriptional response of rubber tree to the cold treatments were determined and a large number of DEGs were characterized including 239 transcription factors, providing important clues for further elucidation of the mechanisms of cold stress responses in rubber tree.

Functional Components and Antioxidant Effects of Colored Onions

Xiao Nan Yang,Enning Xu,Mi Jin Park,In Jong Ha,Jin Seong Moon,Young-Hwa Kang 경북대학교 농업생명과학대학 2015 Current Research on Agriculture and Life Sciences Vol.33 No.2

The antioxidant capacities, total phenolic contents (TPC), and total quercetin contents (TQC) of a red (Chenjujuck), a yellow (Sunpower), and a white (Grasier) onion cultivar were determined in this study. Onion was separated into edible portion and dry skin. In the case of edible portion, the yellow onion had the highest antioxidant activity, followed by the red onion. The white onion showed neither antioxidant activity nor quercetin compounds. On the other hand, the dry skin of the red onion showed higher antioxidant activity than yellow onion skin. The white onion skin had slight antioxidant activity, low TPC, and no quercetin compounds. In addition, the flavonoid compounds of the edible portion and dry skins of these colored onions were analyzed by UFLC(ultra-fast liquid chromatography). The major compounds were quercetin 3,4-diglucoside and quercetin 4- glucoside in yellow and red onion edible portion, whereas the major compounds in yellow and red onion skins were quercetin 4- glucoside, quercetin, and quercetin 3,4-diglucoside.

Review of the Molecular Pathogenesis of Osteosarcoma

He, Jin-Peng,Hao, Yun,Wang, Xiao-Lin,Yang, Xiao-Jin,Shao, Jing-Fan,Guo, Feng-Jin,Feng, Jie-Xiong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Treating the osteosarcoma (OSA) remains a challenge. Current strategies focus on the primary tumor and have limited efficacy for metastatic OSA. A better understanding of the OSA pathogenesis may provide a rational basis for innovative treatment strategies especially for metastases. The aim of this review is to give an overview of the molecular mechanisms of OSA tumorigenesis, OSA cell proliferation, apoptosis, migration, and chemotherapy resistance, and how improved understanding might contribute to designing a better treatment target for OSA.

The Kinase TBK1 controls lgA class switching by negatively regulating noncanonical NF-kF dignaling

( Jin Jin ),( Yichuan Xiao ),( Jae Hoon Chang ),( Jiayi Yu ),( Hongbo Hu ),( Robyn Starr ),( George C Brittain ),( Mikyoung Chang ),( Xuhong Cheng ),( Shao Cong Sun ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0

Immunoglobulin class switching is crucial for the generation of antibody diversity in humoral immunity and, when deregulated, also has severe pathological consequences. How the magnitude of immunoglobulin isotype switching is controlled is still poorly understood. Here we identify thekinase TBK1 as a pivotal negative regulator of class switching to the immunoglobulin A (IgA) isotype. B cell-specific ablation of TBK1 in mice resulted in uncontrolled production of IgA and the development of nephropathy-like disease signs. TBK1 negatively regulated IgA class switchingby attenuating noncanonical signaling via the transcription factor NF-κB, an action that involved TBK1-mediated phosphorylation and subsequent degradation of the NF-κB-inducing kinase NIK. Our findings establish TBK1 as a pivotal negative regulator of the noncanonical NF-κB pathway and identify a unique mechanism that controls IgA production.

從目的論角度看韓國影視劇劇名的中文.譯

Jin Chang-Shan, Zhang Xiao-Ling 조선대학교 국제문화연구원 2013 국제문화연구 Vol.6 No.2

In recent years a growing number of South Korea’s films and TV dramas went intoChina,and they were very popular in cinema, television and DVD. However, as the difference in culture between China and South Korea, the meaning of their names would be changed when they were translated to Chinese. More than 600 South Korean films and TV dramas which were input into China from 2001 to 2012 have been researched in this paper. We discussed the features of their Chinese names and real names and analyzed the translation states of the South Korean film and TV drama in 21st century from aSkopos Theoryperspective.

Dimethylsulfoxide-soluble Smoking Particles and Nicotine Affect Vascular Contractibility

Jin-Yan Zhang,Lei Cao,Cang-Bao Xu,Yong-Xiao Cao,Xiao-Hui Zheng 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10

The aim is to study the effect of dimethylsulfoxide-soluble smoking particles (DSP) and nicotine on the contractility of rat mesenteric artery. The superior mesenteric artery segments were cultured with DSP or nicotine for 24 h. The vascular contractibility was recorded with myograph system. DSP 0.4 mL/L and nicotine 0.48 and 0.96 mg/L shifted the concentrationcontractile curves induced by sarafotoxin 6c, a selective agonist for ETB receptor toward the left with increased Emax. DSP 0.4 mL/L and nicotine 0.96 mg/L shifted ETA receptor-mediated the concentration-contractile curves toward the left with increased Emax. However, nicotine 0.06 mg/L which is the equivalent concentration of nicotine in DSP 0.4 mL/L did not affect the curves and the Emax mediated with ETA receptor and ETB receptor. DSP 0.2 and 0.4 mL/L shifted the concentration-contractile curves induced by noradrenaline toward the right with decreased Emax. Neither did nicotine 0.06 and 0.96 mg/L. Both DSP and nicotine shifted the concentration-contractile curves induced by 5-hydroxytryptamine (5-HT) toward the right parallely. DSP changed the phenotypes towards an increased efficacy of ETA receptor and ETB receptor, and a reduced efficacy of 5-HT receptor and α-adrenocceptor. The effects of DSP on ETB receptor, ETA receptor and α-adrenocceptor were independent of nicotine. The effect on 5-HT receptor was responsible to nicotine.

Experimental Study on the Performance of a Bidirectional Hybrid Piezoelectric-Hydraulic Actuator

Jin, Xiao Long,Ha, Ngoc San,Li, Yong Zhe,Goo, Nam Seo,Woo, Jangmi,Ko, Han Seo,Kim, Tae Heun,Lee, Chang Seop The Korean Society for Aeronautical and Space Scie 2015 International Journal of Aeronautical and Space Sc Vol.16 No.4

The piezoelectric-hydraulic actuator is a hybrid device that consists of a hydraulic pump driven by a piezo-stack coupled to a conventional hydraulic cylinder. The actuator is of compact size, but can produce a moderate energy output. Such hybrid actuators are currently being researched and developed in many industrialized countries due to the requirement for high performance and compact flight systems. In a previous study, we designed and manufactured a unidirectional hybrid actuator. However, the blocking force was not as high as expected. Therefore, in this study, we redesigned the pump chamber and hydraulic cylinder and also improved the system by removing the air bubbles. Two different types of piezo-stacks were used. In order to achieve bidirectional capabilities in the actuator, commercial solenoid valves were used to control the direction of the output cylinder. Experimental testing of the actuator in unidirectional and bidirectional modes was performed to examine performance issues related to driving frequency, bias pressure, reed valve thickness, etc. The results showed that the maximum blocking force was measured as 970.2N when the frequency was 185Hz.

Fatty Acid Synthesis Pathway Genetic Variants and Clinical Outcome of Non-Small Cell Lung Cancer Patients after Surgery

Jin, Xin,Zhang, Ke-Jin,Guo, Xu,Myers, Ronald,Ye, Zhong,Zhang, Zhi-Pei,Li, Xiao-Fei,Yang, Hu-Shan,Xing, Jin-Liang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

Over-expression of de novo lipogenesis (DNL) genes is associated with the prognosis of various types of cancers. However, the effects of single nucleotide polymorphisms (SNPs) in these genes on recurrence and survival of non-small cell lung cancer (NSCLC) patients after surgery are still unknown. In this study, a total of 500 NSCLC patients who underwent surgery treatment were included. Eight SNPs in 3 genes (ACACA, FASN and ACLY) of the DNL pathway were examined using the Sequenom iPLEX genotyping system. Multivariate Cox proportional hazards regression and Kaplan-Meier curves were used to analyze the association of SNPs with patient survival and tumour recurrence. We found that two SNPs in the FASN gene were significantly associated with the recurrence of NSCLC. SNP rs4246444 had a significant association with lung cancer recurrence under additive model (hazard ratio [HR], 0.82; 95% confidence interval [95%CI], 0.67-1.00; p=0.05). Under the dominant model, rs4485435 exhibited a significant association with recurrence (HR, 0.75; 95%CI, 0.56-1.01; p=0.05). Additionally, SNP rs9912300 in ACLY gene was significantly associated with overall survival in lung cancer patients (HR, 1.41; 95%CI, 1.02-1.94, p=0.04) under the dominant model. Further cumulative effect analysis showed moderate dose-dependent effects of unfavorable SNPs on both survival and recurrence. Our data suggest that the SNPs in DNL genes may serve as independent prognostic markers for NSCLC patients after surgery.

《韓國名散文》中國俗語義詞語的漢語翻譯方法硏究

Jin ChangShan,Cui Xiao-Yu 조선대학교 국제문화연구원 2015 국제문화연구 Vol.8 No.1

한 민족어의 의미 체계 속에는 어떤 객체를 표현하는 개념 의미 외에도 해당민족의 역사 문화, 풍속 습관, 민족 정서, 지리 환경등을 표현하는 다양한 문화 상징적 의미도 포함되어 있다. 이런 민족어를 국속(.俗)어휘라고 한다. 한 민족어의 개념의미에 더 첨가된 그 민족만이 갖고 있는 문화 상징적 의미를 국속의미라 하며 이런 국속의미를 연구하는 언어학의 한 분과를 국속의미론이라 한다. 넓은 의미로 말하자면 단어, 성, 속담, 전고 등이 모두 국속어휘에 속한다. 한국어 국속어휘는 한중 문화 교류에서 많이 쓰이고 있으므로 국속어휘의 번역은 단순히 개념의 전환뿐만 아니라 어휘의 은유적인 의미의 다른 문화 간의 전환이라고도 할 수 있어 자못 중요하다. 본 논문의 텍스트 『한국의 명수필』에는 여러 가지 유형의 국속어휘가 씌였는데 그중 단어형 국속어휘가 매우 특징적이다. 단어형 국속어휘는 고유어형 국속어휘와 한자어형 국속어휘 두 가지가 있다. 국속어휘를 온 전하게 번역하면 원문의 뜻을 올바르게 전달할수 있을 뿐만 아니라 독자들의 시야를 넓힐 수도 있다. 본 논문은 『한국의 명수필』에 나타난 단 어형 국속어휘를 대상으로 국속의미론을 적용하여 그 중국어 번역 방법을 모색해 보고자 하였다. 키워드: 국속의미론 국속어휘 중국어 번역

Preparation of Sm-Fe-N by High-Pressure N2 Nitridation and Sm2Fe17 by a Diffusion Process

Xiao, Xiao-Fei,Si, Ping-Zhan,Ge, Hong-Liang,Choi, Chul-Jin Springer-Verlag 2018 Journal of electronic materials Vol.47 No.12