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        Study on changes and mechanisms of cytokines for alloxan-induced hepatic injury by Cr3+-treatment in mice

        Weijiang Fan,Wenhang Wang,Lan Zhang,Lihong Qi,Anjun Liu,Anjun Liu 대한독성 유전단백체 학회 2016 Molecular & cellular toxicology Vol.12 No.2

        This study investigated the effects of treatment with trivalent chromium (Cr3+) on the cytokine levels in mice that had alloxan-induced hepatic injury. The results showed that chromium picolinate (CrPic) may have a protective effect against hepatic injury and that these effects might be related to changes in cytokine expression. Blood ALT and AST levels in the alloxan mice were higher than those in the control and CrPic-treated groups (no significant differences between the latter groups). Luminex assays of cytokines from Th1 (TNF-α, IL-2 and IL-9) and Th2 (IL-3, IL- 5, IL-6, IL-10, IL-13) - as well as G-CSF, M-CSF, and GM-CSF - demonstrated increased levels of TNF-α, IL-2, and IL-9 (55.10%, 1.05-fold, and 2.14-fold, respectively) in alloxan-treated mice compared to control mice. Further, compared to the control group, liver IL- 3, -5, -6, -10, and -13 levels were decreased 2.45-fold, 1.54-fold, 1.01-fold, 12.6% and 37.3%, respectively, in the alloxan-treated mice. In comparison to the control mice, the levels of G-CSF, M-CSF and GM-CSF were decreased in the alloxan-treated mice (25.2%, 49.5%, and 52.9%, respectively). These cytokines were increased 7.91-fold, 43.67% and 34.05%, respectively, in the CrPic-treated group. These findings suggest that Th1/Th2 type cytokines are involved in hepatic injury and induced by alloxan, which may provide a new possible therapeutic approach through CrPic-treatment.

      • Detection of Starch Content in Potato Based on Hyperspectral Imaging Technique

        Wei Jiang,Junlong Fang,Shuwen Wang,Yongcun Fan 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.12

        Detection of starch content in potato is studied applying hyperspectral imaging technique in the paper. The original and preprocessing spectra were processed with partial least square(PLS) method to build prediction model of starch content. The original spectra between 400 and 1000nm was preprocessed with smoothing, second derivation, and multiplicative scatter correction (MSC). Prediction model was built with preprocessing spectra by applying principal component analysis (PCA). Known from the result, the model based on the preprocessing spectra preprocessed with smoothing and PCA is the best of all prediction models built in research. The determination coefficient (R2)of calibration set and prediction set was 0.8234 and 0.9031 respectively. The root mean square error of calibration set (RMSEC) and root mean square error of validation set(RMSEV) was 0.5633 and 0.5025,respectively.It indicated that this method could be applied in detection of starch content in potato. The study could offer theoretical and practical reference for further study in the future.

      • KCI등재

        Synthesis of a novel phosphorus-nitrogen-containing intumescent flame retardant and its application to fabrics

        Wei Jiang,박수진,Fan-Long Jin 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.27 No.-

        A novel phosphorus-nitrogen-containing intumescent flame retardant (IFR), ditrimethylolpropane di-Nhydroxyethylphosphoramide (DDP), was successfully synthesized and used as a flame retardant forvarious fabrics. The chemical structure of DDP was characterized using FT-IR, 1H NMR, 31P NMR, andelemental analysis. The thermal property of DDP was investigated by thermogravimetric analysis. Theeffect of DDP on the flame-retardant properties of fabrics was evaluated by measurement of the burninglength. The optimal synthesis conditions for DDP were determined. DDP showed high flame retardancywhen applied to nylon and moderate flame retardancy when applied to cotton and polyester

      • KCI등재

        Thermo-mechanical behaviors of epoxy resins reinforced with nano-Al2O3 particles

        Wei Jiang,Fan-Long Jin,박수진 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.2

        This study examined the thermo-mechanical behavior of epoxy resins/nano-Al2O3 composites including the curing behavior, thermal stability, dynamic mechanical properties and thermal mechanical properties. The DSC curve peak temperature of the composites was decreased by the addition of nano-Al2O3. The thermal stability of the composites was similar to that of the neat epoxy resins. Dynamic mechanical analysis (DMA) indicated the glass transition temperature of the composites to be approximately 11 8C higher than that of the neat epoxy resins. The coefficient of thermal expansion (CTE)of the composites decreased with increasing nano-Al2O3 content.

      • KCI등재

        Synthesis of ditrimethylolpropane acrylate with low functionality for UV-curable coatings

        Wei Jiang,Fan-Long Jin,박수진 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.5

        An UV-curable acrylic resin, ditrimethylolpropane acrylale (DTMPA), with low functionality was synthesized by esterification of ditrimethylolpropane and acrylic acid. The influences of the synthetic process, such as catalyst, acid/alcohol ratio, inhibitor, solvent, reaction time, and temperature were discussed in detail. The chemical structure of the DTMPA was characterized by FT-IR, 1H NMR, and 13C NMR spectra. The optimal synthesis conditions of the DTMPA were determined, and the resulting product had a yield of 86.5% and pale color. The results of a UV-curing test indicate that the DTMPA has a higher curing speed than that of trimethylolpropane triacrylate.

      • KCI등재

        A novel synthesis of ditrimethylolpropane biphosphoramide diethyleneamine as flame retardant and antistatic textiles

        Wei Jiang,Jin-Feng Li,Zi-Yuan Li,Xiao-Yan Zhang,Fan-Long Jin,박수진 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.4

        A novel phosphorous- and nitrogen-containing flame retardant, ditrimethylolpropane biphosphoramide diethyleneamine (DBD), was synthesized. Its chemical structure is characterized by Fourier-transform infrared spectroscopy and 1H nuclear magnetic resonance spectroscopy. The effect of DBD on the physical, mechanical, and antistatic properties, thermal stability, and flame retardancy of wool fabric was systematically investigated. Thermogravimetric analysis showed that the initial decomposition temperature of DBD was 165 oC and 243 oC under nitrogen and air atmosphere, respectively. Furthermore, after 30 washes, the treated wool fabric exhibited excellent wash durability and good antistatic properties. Vertical burning tests indicated that both the burning time and char length of the treated wool fabric were lower than those of the flame-retardant standard, leading to a B1 flame retardant rating for the treated wool fabric. Compared to untreated wool fabric, the limiting oxygen index value of treated wool fabric increased significantly from 25.7% to 34.7%.

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