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Wang Fei,Luo Defan,Chen Jianxiang,Pan Cuiqing,Wang Zhongyao,Fu Housheng,Xu Jianbing,Yang Meng,Mo Shaowei,Zhuang Liying,Ye Liefu,Wang Weifu 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.2
Purpose: Genetic factors play an indispensable role in the pathogenesis of lifelong premature ejaculation (LPE). The suscep-tibility genes/SNPs that have been discovered are very limited and can only explain part of the genetic effects of LPE. There-fore, discovering more genetic polymorphisms associated with the occurrence and development of LPE will help reveal the pathogenesis of LPE. Materials Materials and and Methods:Methods: We conducted a genome-wide association study of LPE in 486 Chinese male Han people (cases and controls). We used Gene Titan multi-channel instrument and Axiom Analysis Suite 6.0 software for genotyping. Imputation was performed by IMPUTE2 software and the 1000 Genomes Project (Phase3) was used as reference for haplotype. Finally, logistic regression analysis was performed on all loci that passed the quality control. The odds ratio and 95% confidence in-terval were calculated to determine the association between each SNPs and Chinese male Han population LPE risk. Results:Results: The results showed that a total of 33 genetic variants in 13 genes (LACTBL1 , SSBP3 , ACOT11 , LINC02486 , TMEM154, LINC01098, NONE, HCG27, HLA-C, TNFSF8, TNC, FAM53B, SULF2) have a suggestively significant genome-wide association with LPE risk (p<5×10-6). Conclusions:Conclusions: This study is the first to conduct a GWAS on LPE in Chinese male Han population 33 genetic polymorphisms have a suggestive genome-wide association with LPE risk. This study have provided data supplement for the genetic loci of LPE risk, and laid a scientific foundation for the pathogenesis and the targeted therapy of LPE.
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Zhongyao Zhang,Xiaopeng Chen,Jiezhen Liang,Xiaojie Wei,Kaixi Deng,Jiezhong Zou,Linlin Wang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-
The petrol-based random copolymer, e.g., aromatic-hydrocarbon resin, is widely used in industrial production,but the research about its gas–liquid two flow is far from being solved. Herein, the formation,motion, and deformation of a single bubble in six different concentrations of random copolymer solutionswere systemically investigated using high-speed photography (1000 fps), combined with digital imageprocessing technology. The departure time of the bubble first decreases and then increases, and maximumof aspect ratio and specific surface area reduce as the proportion of solute increases. The bubbledeparture time decreases and bubble size increases with viscous force increases in the case of same surfacetension. Based on force balance analysis, added mass force is one of the prime reasons to affect bubbleoscillation during the acceleration phase after bubble detachment, whereas the effect of added massforce decreases as solute increases or as the bubble reaches stability zone. Also, velocity, drag coefficientand aspect ratio of bubble were discussed in detail by dimensionless analysis. Furthermore, three newshape numerical models (based on We, Ta, and WeEo, respectively) were proposed, which allowed for satisfactorypredictions, and new correlations represent well the experimental data in a wider range of Monumbers from the mentioned literature (11.6 logMo 0.63).
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