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Acupuncture for Osteoporosis: a Review of Its Clinical and Preclinical Studies
Tian Yimiao,Wang Lili,Xu Tianshu,Li Rui,Zhu Ruyuan,Chen Beibei,Zhang Hao,Xia Bingke,Che Yiwen,Zhao Dandan,Zhang Dongwei 사단법인약침학회 2022 Journal of Acupuncture & Meridian Studies Vol.15 No.5
Acupuncture has gained growing attention in the management of osteoporosis (OP). However, a comprehensive review has not yet been conducted on the efficacy and challenges of acupuncture in preliminary research and clinical trials. Therefore, an extensive literature search was conducted using electronic databases, including PubMed (www.ncbi.nlm.nih.gov/pubmed), CNKI (www.cnki.net), and Web of Science, for studies published from the beginning of 2000 to the end of May 2022. Combinations of synonyms for OP, acupuncture, traditional Chinese medicine, clinical trial, preclinical study, and animal experiments were searched. A total of 290 papers were consulted, including 115 reviews, 109 clinical observations, and 66 preclinical studies. There is accumulating evidence to support the beneficial role of acupuncture in preserving bone quality and relieving clinical symptoms based on clinical and preclinical investigations. The top ten most commonly used acupoints are BL23, ST36, BL20, BL11, CV4, GV4, SP 6, KI3, BL18, and GB39. The underlying mechanisms behind the benefits of acupuncture may be linked with the regulation of the hypothalamic-pituitary-gonadal (adrenal) axis and activation of the Wnt/β-catenin and OPG/RANKL/RANK signaling pathways. In summary, strong evidence may still come from prospective and well-designed clinical trials to shed light on the potential role of acupuncture in preserving bone loss. Future investigations are needed to explore the potential underlying mechanisms, long-term clinical efficacy, and compliance of acupuncture in OP management.
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Preparation and application of graphene oxide nanocomposites loaded with enzymes and liposomes
Yu Yifan,Wang Ruyuan,Li Meilin,Li Shanshan,Fan Aiping 한국탄소학회 2023 Carbon Letters Vol.33 No.4
The present studies explored the possibility of immobilizing phosphocholine (PC) liposomes on the surface of graphene oxide (GO) which was pre-adsorbed with two kinds of enzymes, horseradish peroxidase and glucose oxidase. The transmission electron microscope images showed that the PC liposomes adsorbed onto the GO surface kept integrity. By using 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-encapsulated liposomes, a one-step colorimetric assay for glucose was developed. In the presence of glucose, the GO nanocomposites catalyzed the cascade enzymatic reaction producing colorimetric signals directly. Under the optimal conditions, the GO nanocomposites produced linearly increased colorimetric signal with increased concentrations of glucose ranging from 50 to 500 µM. The detection limit was 33 µM. The GO nanocomposites also exhibited good selectivity for the detection of glucose and were able to detect glucose in human serum.
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Yang Gang,Liu Xin,Huang Tianyu,Ding Ruyuan,Wang Yuanyin 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.1
BACKGROUND: Teeth can be used as a raw material for preparing bone substitutes due to their similar chemical composition to bone. The objective of our study was to evaluate the effect of odontogenic biphasic calcium phosphate (BCP) incorporating dentin noncollagenous proteins (DNCPs) on osteogenesis and stability in maxillary sinus augmentation. METHODS: The composition, structure and morphology of the odontogenic BCP were tested by X-ray powder diffraction (XRD), Brunauer–Emmett–Teller, and scanning electron microscopy methods. The biocompatibility and osteoinduction of DNCPs and materials were examined in vitro and their bone regeneration capacity was verified in vivo. RESULTS: The results showed that the cells adhered and proliferated well on the DNCP-loaded BCP scaffold. The odontogenic BCP and DNCPs promoted osteogenic differentiation of cells, The new bone formation in the BCP groups and DNCP subgroups was significantly higher than the new bone formation in the control, and the new bone quality was better. The bone regeneration effect of odontogenic BCP was similar to the effect of deproteinized bovine bone mineral, but b- TCP did not maintain the height and volume of bone reconstruction. CONCLUSION: In conclusion, the combined application of DNCPs and odontogenic BCP is an effective strategy for tissue engineering osteogenesis in the maxillary sinus region. The biomimetic strategy could provide a new approach for patients requiring maxillary sinus lifting.
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Zhu Zhendong,Zhao Haolong,Yang Qitai,Li Yajing,Wang RuYuan,Adetunji Adedeji Olufemi,Min Lingjiang 아세아·태평양축산학회 2024 Animal Bioscience Vol.37 No.5
Objective: The present study aimed to investigate the effect of β-nicotinamide mononucleotide (NMN) supplementation on ram sperm quality during storage at 4°C in vitro. Methods: Tris-citric acid-glucose solution containing different doses of NMN (0, 30, 60, 90, and 120 μM) was used to dilute semen collected from rams and it was stored at 4°C. Sperm motility, plasma membrane integrity as well as acrosome integrity were evaluated at 0, 24, and 48 h time points after storage at 4°C. In addition, sperm mitochondrial activity, lipid peroxidation (LPO), malondialdehyde (MDA) content, reactive oxygen species (ROS) content, glutathione (GSH) content, superoxide dismutase (SOD) activity, and apoptosis were measured at 48 h time point after storage at 4°C. Results: Results demonstrate that the values obtained for sperm motility, acrosome integrity, and plasma membrane integrity in the NMN treatments were significantly higher than control (p<0.05). The addition of 60 μM NMN significantly improved ram sperm mitochondrial activity and reduced LPO, MDA content, and ROS content compared to control (p<0.05). Interestingly, sperm GSH content and SOD activity for the 60 μM NMN treatment were much higher than those observed for control. NMN treatment also decreased the level of Cleaved-Caspase 3, Cleaved-Caspase 9, and Bax while increasing Bcl-2 level in sperm at 48 h time point after storage at 4°C. Conclusion: Ram sperm quality can be maintained during storage at 4°C with the addition of NMN at 60 μM to the semen extender. NMN also reduces oxidative stress and apoptosis. Overall, these findings suggest that NMN is efficient in improving the viability of ram sperm during storage at 4°C in vitro.
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