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- 검색키워드
- 저자 : Vendruscolo, Michele (검색결과 5 건)
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I. Takaki,L.E. Bersani-Amado,A. Vendruscolo,S.M. Sartoretto,S.P. Diniz,C.A. Bersani-Amado,R.K.N. Cuman 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.4
Rosmarinus officinalis L. (Family Lamiaceae), popularly named rosemary, is a common household plant grown in many parts of the world, including Brazil. Rosemary leaves are used for food flavoring and have been used in folk medicine for many conditions; they have antispasmodic, analgesic, antirheumatic, carminative, cholagogue, diuretic, expectorant, and antiepileptic effects. The objective of this study was to evaluate the effects of rosemary essential oil (REO) on experimental models of nociception and inflammation in animals. The anti-inflammatory effect of REO was evaluated by inflammatory exudate volume and leukocyte migration in carrageenan-induced pleurisy and carrageenan-induced paw edema tests in rats. Antinociception was evaluated using the acetic acid-induced writhing and hot plate tests in mice. REO (500 mg/kg) significantly reduced the volume of pleural exudate and slightly decreased the number of cells that had migrated compared with the control animals. At doses of 250, 500, and 750 mg/kg, REO significantly inhibited carrageenan-induced edema 1–4 hours after injection of the phlogistic agent. In the hot plate test, REO administration (125, 250, and 500 mg/kg) showed unremarkable effects on response latency, whereas control injection of meperidine induced significant antinociceptive effects. REO at doses of 70, 125, and 250 mg/kg had a significant antinociceptive effect in the acetic acid-induced abdominal writhing test compared with control animals. These data suggest that REO possesses anti-inflammatory and peripheral antinociceptive activity.
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Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation
Ahn, Minkoo,Lee, Byung Il,Chia, Sean,Habchi, Johnny,Kumita, Janet R.,Vendruscolo, Michele,Dobson, Christopher M.,Park, Chan Beum The Royal Society of Chemistry 2019 Chemical communications Vol.55 No.8
<P>The self-assembly of the beta-amyloid peptide (Aβ) into amyloid aggregates is a central phenomenon associated with Alzheimer's disease. Here, we report chemical modifications of key amino acid residues of Aβ42 (Y10, H13, H14, and M35) by photoexcited thioflavin-T (ThT), a fluorescent probe of amyloid structure. The quantitative chemical kinetics analysis shows that the oxidized monomer species does not self-assemble, nor perturb the aggregation kinetics of non-oxidized Aβ42.</P>
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Carlos Eduardo da Silva Oliveira,Tiago Zoz,Eduardo Pradi Vendruscolo,Agner de Freitas Andrade,Cássio de Castro Seron,Travis Wilson Witt 한국작물학회 2020 Journal of crop science and biotechnology Vol.23 No.5
The sowing operation is crucial for the proper initial establishment of seedlings and their development. However, there is a lack of studies about the eff ects of sowing depth of rice, as well as technologies that aid to mitigate the prejudicial eff ects caused by depth. In this way, the present work aimed to evaluate the initial growth of rice plants inoculated with Azospirillum brasiliense and treated with biostimulant sowed at diff erent depths. Randomized complete block design with four replica�tions was used, in a 4 × 4 factorial scheme. The fi rst factor was composed of diff erent seed treatments (a, control—with�out treatment; b, inoculation with A. brasilense ; c, seed treatment with Stimulate® and d, inoculation with A. brasilense associated with seed treatment with Stimulate ® ). The second factor was composed of four sowing depths (1.0, 3.0, 5.0 and 7.0 cm). Treatment of rice seeds with A. brasilense and Stimulate® decreases the rate of emergence. The sowing at 7 cm depth decreases in 41.44% of the emergence, when compared to sowing at 1 cm. Inoculation with A. brasilense and sowing at increasing depths are prejudicial to the growth of rice crop.
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Vitor Hugo Candido Ferreira,Aristilia Tahara Kemp,Joana Vendruscolo,Laurindo Moacir Sassi,Juliana Lucena Schussel 대한구강악안면외과학회 2021 대한구강악안면외과학회지 Vol.47 No.1
Objectives: The aim of this study was to evaluate the profile of patients on antiresorptive therapies for cancer treatment and assess presence of oral lesions, oral hygiene status, and knowledge regarding medication-related osteonecrosis of the jaw (MRONJ). Materials and Methods: This was an observational cross-sectional study that evaluated patients treated with antiresorptive medication at a single cancer hospital. Clinical data were collected and oral examination was performed to assess patient oral health. Results: From July 2017 to December 2018, 90 patients were assessed; 64 were female and 26 were male, and the mean age was 61 years. The most common drug was an intravenous bisphosphonate, zoledronic acid. Among the 90 patients, 47 presented with some type of oral disease, isolated or associated. Among these 47 patients, 9 patients (10%) developed osteonecrosis. Oral hygiene was evaluated, and most patients, with or without MRONJ, presented with regular to poor condition. Regarding patient knowledge of the risks of MRONJ and the risks associated with dental surgery, 60% stated that they were not aware of the risks. Conclusion: Identifying the profile of patients and their needs facilitates not only the preventive process, but also the emergence of new therapeutic options. Our study shows that most patients are weakened both by metastatic disease and antineoplastic treatment as well as by issues associated with aging because most were over 60 years of age. Collectively, this information should be considered for management of preventive and therapeutic measures.
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Henrique M. Neuenschwander,Juliana J. Moreira,Cynthia P. Vendruscolo,Joice Fülber,Sarah R. T. Seidel,Yara M. Michelacci,Raquel Y. A. Baccarin 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.6
The intra-articular use of hyaluronic acid (HA) for the treatment of synovitis and osteoarthritis is still controversial. As a consequence, corticosteroids remain the most frequently employed therapeutic agents, despite their potential systemic and local deleterious effects. This study examined the anti-inflammatory, antioxidant, and chondroprotective activities of low and high molecular weight hyaluronic acid (LMW-HA and HMW-HA) on lipopolysaccharide (LPS)-induced synovitis in horses compared to triamcinolone acetonide (TA). LPS was injected in the metacarpophalangeal joints, which were treated intra-articularly with either TA (as control) or LMW-HA or HMW-HA. Joint clinical evaluation and synovial fluid (SF) analysis were performed at 0, 8, 24, and 48 h. The white blood cell counts (WBC), prostaglandin E2 (PGE2), interleukin (IL)-1, IL-6, IL-10, tumor necrosis factor-α, chondroitin sulfate (CS) and HA concentrations, oxidative burst, and HA molecular weights were measured. TA reduced the lameness, swelling, and PGE2 release but increased the SF CS concentrations enormously at 24 h and 48 h. In contrast, TA decreased the SF HA modal molecular weight. These results indicate the breakdown of articular cartilage aggrecan and SF HA. In contrast, LMW-HA and HMW-HA were less effective in reducing the inflammation symptoms, but preserved the joints because only a modest increase in CS occurred at 24 h, decreasing at 48 h, and the SF HA was maintained. The HA-treatment also had anti-inflammatory actions, and LMW-HA was the most effective in reducing the release of cytokine. In summary, the HA treatment inhibited efficiently the digestion of cartilage proteoglycans and SF HA breakdown.
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