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Nikolaos K. Andrikopoulos,Andriana C. Kaliora,Andreana N. Assimopoulou,Vassilios P. Papageorgiou 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.1
The minor polyphenolic and nonpolyphenolic constituents of olive oil were examined, in var-ious doses, against copper ion induced low-density lipoprotein (LDL) oxidation and werefound, in optimal doses (final concentration, 10 mM or 20 mM), to have remarkable biologi-cal activity, contributing to that previously reported for the major phenolic compounds. Themain phytosterols, b-sitosterol, campesterol, and stigmasterol, were found to have 43.8%,37.3%, and 3.4% LDL mean protection (MP) activity, respectively, while free cholesterol ex-hibited 43.2% MP. The triterpenoid derivative compounds, ursolic acid, uvaol, and oleanolicacid, had similar MP activities of 50.5%, 46.8%, and 46.0%, respectively. Tocopherol (Toc) iso-mers exhibited an increasing effect in the following order: a-Toc (33.6%) , b-Toc (36.1%) ,g-Toc (42.9%) , d-Toc (46.0%). The flavonoid polyphenols, quercetin, luteolin, and rutin, ex-hibited the highest activities 46.8%, 49.5%, and 53.7% MP, respectively, comparable to the49.0% MP activity found for oleuropein. These findings indicate the relative independenceof LDL protection activity in regard to structural differences among the involved compounds.A relation to the Mediterranean diet is also demonstrated.
Athanasios S. Arampatzis,Konstantinos N. Kontogiannopoulos,Konstantinos Theodoridis,Eleni Aggelidou,Angélique Rat,Anne Willems,Ioannis Tsivintzelis,Vassilios P. Papageorgiou,Aristeidis Kritis,Andreana 한국생체재료학회 2021 생체재료학회지 Vol.25 No.3
Background: Current research on skin tissue engineering has been focusing on novel therapies for the effective management of chronic wounds. A critical aspect is to develop matrices that promote growth and uniform distribution of cells across the wound area, and at the same time offer protection, as well as deliver drugs that help wound healing and tissue regeneration. In this context, we aimed at developing electrospun scaffolds that could serve as carriers for the bioactive natural products alkannin and shikonin (A/S). Methods: A series of polymeric nanofibers composed of cellulose acetate (CA) or poly(ε-caprolactone) (PCL) and varying ratios of a mixture of A/S derivatives, has been successfully fabricated and their physico-chemical and biological properties have been explored.