http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Vasanthan Ravichandran,Thuy Giang Nguyen Cao,Dae Gun Choi,Han Chang Kang,Min Suk Shim 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.88 No.-
Combination therapy has gained great attraction as an effective strategy for the treatment of cancers. Inthis study, non-ionic polysorbate-based nanoparticles were prepared for combination chemo/photo-thermal/photodynamic cancer therapy via effective intracellular delivery of piperlongumine (PL) andindocyanine green (ICG). PL was used as a pro-oxidant drug that can induce selective apoptosis throughthe increase of oxidative stress in cancer cells. ICG was used as a near-infrared (NIR) light-absorbingphotothermal and photodynamic agent. Non-ionic Tween 80 (T80) polysorbate was used to prepare PLandICG-loaded micelles with nanoscale diameters. Both PL and ICG were efficiently encapsulated in theT80-based micelles. Storage stability of ICG in aqueous solutions was greatly improved by encapsulationinto the T80-based micelles. ICG-loaded T80 micelles (ICG-T80) showed higher photothermal conversionefficiency than free ICG. T80 also increased cellular uptake of ICG. Moreover, ICG-T80 showed NIR lighttriggeredreactive oxygen species (ROS) generation in MCF-7 human breast cancer cells, owing to thephotodynamic effects of NIR light-absorbing ICG. PL-loaded T80 micelles also increased intracellular ROSlevels in MCF-7 cells owing to the pro-oxidant activity of PL. In vitro study showed that ICG-T80 micellesexhibited efficient anticancer activity under NIR irradiation via combined photothermal therapy (PTT)and photodynamic therapy (PDT). PL- and ICG-loaded T80 micelles (PL-ICG-T80) further increased thecytotoxicity via combined chemo/PTT/PDT. PL-ICG-T80 also showed cancer-selective cytotoxicity. Thisstudy demonstrates that PL-ICG-T80 micelles are effective for NIR light-triggered combination chemo/PTT/PDT.
Vasanthan Ravichandran,Quan Truong Hoang,Thuy Giang Nguyen Cao,심민석 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-
Sonodynamic therapy (SDT) has emerged as a promising noninvasive therapeutic modality due to itsdeep tissue penetration depth. Herein, biodegradable poly(lactic-co-glycolic acid) (PLGA) nanocapsulesencapsulating oxygen-deficient MnWOx nanoparticles (NPs) and doxorubicin (DOX) were fabricatedfor chemo-sonodynamic combination therapy against cancer. To achieve cancer-targeted chemo-SDT,PLGA was conjugated to a cancer-targeting biotin through poly(ethylene glycol) (PEG). Biotin-PEG-PLGA (BP-PLGA) nanocapsules encapsulating DOX and hydrophobic MnWOx NPs(BP-PLGA-DOX@MnWOx) exhibited high physiological stability and pH-responsive drug release. Theoxygen-deficient MnWOx NPs enabled US-triggered generation of singlet oxygen and hydroxyl radicalsowing to their oxygen-deficient structures that prevent electron–hole recombination. Glutathione(GSH) depletion by MnWOx-loaded PLGA nanocapsules was observed in MCF-7 human breast cancercells, which leads to augmented intracellular ROS levels and sonodynamic effects. Notably,BP-PLGA-DOX@MnWOx greatly improved cellular uptake by breast cancer cells, resulting in efficientintracellular delivery of DOX and MnWOx NPs. As a result, BP-PLGA-DOX@MnWOx exhibited efficientand cancer-targeted cytotoxicity in MCF-7 cells upon US irradiation. This study demonstrates that BPPLGA-DOX@MnWOx nanocapsules are promising cancer-targeting nanosonosensitizers for efficientchemo-sonodynamic cancer therapy.