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Carboxymethyl dextran-cyclodextrin conjugate as the carrier of doxorubicin.
Sivasubramanian, Maharajan,Thambi, Thavasyappan,Deepagan, V G,Saravanakumar, Gurusamy,Ko, Hyewon,Kang, Young Mo,Park, Jae Hyung American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.11
<P>The carboxymethyl dextran-y-cyclodextrin (CMD-yCD) conjugate was prepared as the carrier for the delivery of the poorly water-soluble anticancer drug, doxorubicin (DOX). The conjugate could form self-assembled nanoparticles (315 nm in diameter) in an aqueous solution, which might be due to the hydrogen bonding among yCD molecules in the conjugate. DOX was effectively encapsulated into CMD-yCD nanoparticles (CMD-NPs) by the emulsion method. In particular, regardless of the feed amount of DOX, its loading efficiencies were always greater than 70%. CMD-NPs released DOX in a sustained manner, owing to the inclusion complex formation between DOX and yCD. When Cy5.5-labeled CMD-NPs were treated with SCC7 cancer cells, strong fluorescence signals were observed at the cytosol, indicating effective intracellular uptake. In addition, DOX-loaded CMD-NPs exhibited dose-dependent cytotoxicity to SCC7 cancer cells. However, the empty nanoparticles did not show toxicity to the cells, implying their high biocompatibility. Overall, these results suggest that the CMD-gammaCD conjugate could be a useful carrier for the delivery of DOX.</P>
M. Jayaraman,R. Sivasubramanian,S. Babu,V. Balasubramanian 대한금속·재료학회 2009 METALS AND MATERIALS International Vol.15 No.2
Fusion welding of cast A319 (Al-Si-Cu) alloy will lead to many problems including porosity, micro-fissuring, and hot cracking. Friction Stir Welding (FSW) can be used to weld A319 alloy without these defects. In this investigation, an attempt has been made to study the effect of FSW process parameters on the tensile strength of A319 alloy welded joints. Joints were made using different combinations of tool rotation speed, welding speed, and axial force, each at four levels. The quality of weld zone was analyzed using macrostructure and microstructure analysis. Tensile strength of the joints were evaluated and correlated with the weld zone microstructure. The joint fabricated with a 1200 rpm tool rotation speed, 40 mm/min welding speed, and 4 kN axial force showed superior tensile strength compared with the other joints. Fusion welding of cast A319 (Al-Si-Cu) alloy will lead to many problems including porosity, micro-fissuring, and hot cracking. Friction Stir Welding (FSW) can be used to weld A319 alloy without these defects. In this investigation, an attempt has been made to study the effect of FSW process parameters on the tensile strength of A319 alloy welded joints. Joints were made using different combinations of tool rotation speed, welding speed, and axial force, each at four levels. The quality of weld zone was analyzed using macrostructure and microstructure analysis. Tensile strength of the joints were evaluated and correlated with the weld zone microstructure. The joint fabricated with a 1200 rpm tool rotation speed, 40 mm/min welding speed, and 4 kN axial force showed superior tensile strength compared with the other joints.
R.G. Joshi,K.K. Mishra,V. Sivasubramanian,B.V.R. Tata 한국물리학회 2016 Current Applied Physics Vol.16 No.10
We report the propagation of sound waves in a suspension of dense thermo-responsive poly(N-isopropyl acrylamide) (PNIPAM) microgels as a function of temperature using Brillouin light scattering. In the dense PNIPAM microgel glass, a single longitudinal acoustic (LA) mode is found to propagate at the velocity intermediate between that of polymer and water phases, and is attributed to the sound wave propagating through the water-microgel composite media. The LA mode shows two interesting features with respect to temperature: i) frequency of LA mode increases upon increase in temperature with anomalous behavior in the vicinity of glass transition and volume phase transition temperatures, ii) the width of LA mode shows minimum near volume phase transition temperature. These observations are attributed to the variation of size and elasticity of PNIPAM microgel particles with temperature. At room temperature the static and dynamic light scattering (DLS) studies on dense PNIPAM microgel suspension confirm a glassy state. In addition, DLS is used to identify the volume phase transition of microgels and glass transition of dense suspension. These temperatures corresponding to glass transition and volume phase transition are found to be consistent with that obtained from Brillouin light scattering results.