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Dembereldorj, Uuriintuya,Kim, Mira,Kim, Semi,Ganbold, Erdene-Ochir,Lee, So Yeong,Joo, Sang-Woo The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.45
<P>Both <I>in vitro</I> and <I>in vivo</I> glutathione (GSH)-triggered anticancer drug releases were monitored in real time from the PEGylated graphene oxide (PEG-GO) platform. The assembly of the anticancer drug doxorubicin (DOX) on PEG-GO was verified by UV-Vis absorption and infrared spectroscopic tools. The fluorescence of DOX appeared to be quenched significantly by PEG-GO. A part of the initial DOX (10<SUP>−4</SUP> M) in PEG-GO was found to be released by ∼23.5% after treatment with 2 mM glutathione (GSH) within 15 min. Our fluorescence colocalization experiments indicated that PEG-GO–DOX was endocytosed and localized in either lysosomes or endosomes of intracellular compartments. Using fluorescence imaging techniques in real time, we were able to observe an approximately 2.5 times higher <I>in vitro</I> drug release in the live cells by externally triggering glutathione ethyl ester (GSH-OEt) rather than endogeneous GSH. <I>In vivo</I> fluorescence images of DOX were obtained with an order of magnitude larger intensity from the subcutaneous site in living mice after treatment with 0.3 mg of GSH. A real-time release of DOX on PEG-GO at the intended locus can be achieved <I>in vivo</I> after an external triggering of GSH.</P> <P>Graphic Abstract</P><P>Real-time monitoring of glutathione (GSH)-induced anticancer drug release was achieved using the PEGylated graphene oxide (PEG-GO) platform both <I>in vitro</I> and <I>in vivo</I>. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm34853e'> </P>
Dembereldorj, Uuriintuya,Joo, Sang-Woo Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.1
Adsorption structures of the self-assembled thin films of $\alpha$-cyano-4-hydroxycinnamic acid (CHCA) anchoring on $TiO_2$ surfaces have been studied by using temperature-dependent diffuse reflectance infrared Fourier-transform (DRIFT) spectroscopy. From the presence of the strong $\nu(COO^-)$ band at ~1390 $cm^{-1}$ along with the disappearance of the OH bands in the carboxylic acid group in the DRIFT spectra at room temperature, CHCA appeared to adsorb onto $TiO_2$ surfaces as a carboxylate form. The absence of the out-of-plane benzene ring modes of CHCA in the DRIFT spectra suggests a rather vertical orientation of CHCA on $TiO_2$. Above ~220$ ^{\circ}C$, CHCA seemed to start to thermally degrade on $TiO_2$ surfaces referring from the disappearance of most vibrational modes in the DRIFT spectra, whereas the $\nu$(C ≡ N) bands were found to remain relatively conspicuous as the temperature increased even up to ~460$^{\circ}C$.
Uuriintuya Dembereldorj,주상우 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.1
Adsorption structures of the self-assembled thin films of α-cyano-4-hydroxycinnamic acid (CHCA) anchoring on TiO2surfaces have been studied by using temperature-dependent diffuse reflectance infrared Fourier-transform (DRIFT)spectroscopy. From the presence of the strong ν(COO−) band at ~1390 cm-1 along with the disappearance of the OH bands in the carboxylic acid group in the DRIFT spectra at room temperature, CHCA appeared to adsorb onto TiO2 surfaces as a carboxylate form. The absence of the out-of-plane benzene ring modes of CHCA in the DRIFT spectra suggests a rather vertical orientation of CHCA on TiO2. Above ~220 oC, CHCA seemed to start to thermally degrade on TiO2 surfaces referring from the disappearance of most vibrational modes in the DRIFT spectra, whereas the ν(C ≡ N) bands were found to remain relatively conspicuous as the temperature increased even up to ~460 C.
Hydrogen bonding-induced color recovery of gold nanoparticles upon conjugation of amino acids
Park, Jin-Ho,Ganbold, Erdene Ochir,Uuriintuya, Dembereldorj,Lee, Kangtaek,Joo, Sang-Woo The Royal Society of Chemistry 2009 Chemical communications Vol.2009 No.47
<p>Hydrogen bonding-induced redispersion of the aggregated Au nanoparticles upon <I>N</I>-hydroxysuccinimide ester bioconjugations may provide a simple and colorimetric tool as an optical sensor to detect a trace amount of amino acids as low as ∼10<SUP>−6</SUP> M in an aqueous solution.</p> <P>Graphic Abstract</P><P>Redispersion of the aggregated Au nanoparticles induced by hydrogen bonding between the amide linkages may provide a useful optical sensor of the amino acid bioconjugations. <img src='http://pubs.rsc.org/ej/CC/2009/b918687e/b918687e-ga.gif'> </P>
Infrared spectroscopy characterization of normal and lung cancer cells originated from epithelium
So Yeong Lee,Kyong-Ah Yoon,장수화,Erdene Ochir Ganbold,Dembereldorj Uuriintuya,Sang-Mo Shin,류판동,주상우 대한수의학회 2009 JOURNAL OF VETERINARY SCIENCE Vol.10 No.4
The vibrational spectral differences of normal and lung cancer cells were studied for the development of effective cancer cell screening by means of attenuated total reflection infrared spectroscopy. The phosphate monoester symmetric stretching νs(PO32-) band intensity at ∼970 cm-1 and the phosphodiester symmetric stretching νs(PO2-) band intensity at ∼1,085 cm-1 in nucleic acids and phospholipids appeared to be significantly strengthened in lung cancer cells with respect to the other vibrational bands compared to normal cells. This finding suggests that more extensive phosphorylation occur in cancer cells. These results demonstrate that lung cancer cells may be prescreened using infrared spectroscopy tools.