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A dense, pinholes-free pure cubic phase CsPbBr3 nanocrystals film for high-performance photodetector
Thanh-Tung Duong,Phuong-Nam Tran,Tuan-Pham Van,Duy-Hung Nguyen,Van-Dang Tran 대한금속·재료학회 2024 ELECTRONIC MATERIALS LETTERS Vol.20 No.2
This study demonstrates a simple centrifugal coating method to prepare high-quality pure cubic phase CsPbBr 3 nanocrystalfi lm. The resultant perovskite layers possess a uniform and dense 500 nm-thick, with a bandgap of 2.38 eV, a low trap-statedensity of 6.9 × 10 − 15 cm − 3 , and carrier mobility of approximately 19.8 cm 2 V − 1 s − 1 . Furthermore, CsPbBr 3 NCs-basedself-powered photodetectors with high charge carriers’ charge transfer are fabricated. The device shows a low dark currentdensity of 1.93 × 10 − 7 A/cm 2 at room temperature. Such photodetectors show the highest responsivity of 3.0 AW − 1 ,specifi c detectivity of 1.2 × 10 13 Jones, and external quantum effi ciency (EQE) of 920% at zero bias voltage. The proposedmethod shows signifi cant promise for use in the lab fabrication of optoelectronic devices based on thin fi lms of nanocrystalperovskite materials.
Tran, Tuan Hiep,Nguyen, Hanh Thuy,Pham, Tung Thanh,Choi, Ju Yeon,Choi, Han-Gon,Yong, Chul Soon,Kim, Jong Oh American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.51
<P>Despite tremendous progress in chemotherapy, drug resistance remains a major challenge for anticancer treatment. The combinations of chemo-photothermal and chemo-chemo treatments have been reported to be potential solutions to overcome drug resistance. In this study, we developed a dual-in-dual synergistic therapy based on the use of dual anticancer drug-loaded graphene oxide (GO) stabilized with poloxamer 188 for generating heat and delivering drugs to kill cancer cells under near-infrared (NIR) laser irradiation. The nanocomparable system is stable and uniform in size, generating sufficient heat to induce cell death. Dual drugs (doxorubicin and irinotecan)-loaded GO (GO-DI) in combination with laser irradiation caused higher cytotoxicity than that caused by the administration of a free single drug as well as a combination of drugs and blank GO in various cancer cells, especially in MDA-MB-231 resistant breast cancer cells. Exposure to “hot” NIR and GO-DI activated the intrinsic apoptosis pathway, which was confirmed based on changes in the morphology of cell nuclei and overexpression of apoptosis-related proteins. On the basis of the results, the combined treatment showed a synergistic effect compared to the effect of chemotherapy or photothermal treatment alone, demonstrating higher therapeutic efficacy to overcome one of the most severe problem in anticancer therapy, that of intrinsic resistance to chemotherapeutics.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2015/aamick.2015.7.issue-51/acsami.5b10426/production/images/medium/am-2015-104266_0005.gif'></P>
Thanh Bui Trung,Van Pham Hung,Hai Tran Hoang,Le Minh Tung,이재령 한국자원공학회 2015 Geosystem engineering Vol.18 No.4
A method for detecting glypican 3 (GPC3) liver cancer cells by coupling of anti-glypican 3 antibody (anti-GPC3) and magnetite nanoparticles (NPs) was investigated to detect GPC3 by enzyme-linked immunosorbent assay (ELISA) in this study. Magnetite NPs with the average size of 11 nm were synthesized by using co-precipitation method of Fe2+ and Fe3+ in NH3·H2O solution. First, silica was coated on the magnetite NPs using Stöber method to obtain Fe3O4/SiO2 core-shell structures and then 3-aminopropyltriethoxysilane (APTES) was treated on the Fe3O4/SiO2 by silanization reaction to achieve Fe3O4/SiO2/APTES nanostructures. After modified by APTES, the nanostructures were activated by glutaraldehyde (GA) to obtain functional groups on the nanostructures surface to bind with anti-GPC3 by covalent immobilization. The UV–vis spectroscopy was carried out to investigate the binding of anti-GPC3 to the NPs and binding efficiency (88.35%) was estimated by the Bradford method. The NPs bound anti-GPC3 (NPs/anti-GPC3) can detect GPC3 by using ELISA at low concentration (0.16 ng/ml).