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      • Case Study Report Electrochemical Capacitor Latest Application

        Toshihiko Furukawa,Naoki Akiba,Hiroyuki Wakabayashi,Shin Watanabe,Shinichi Matsunaga,Masakazu lsobe,Takariro Kikuta 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

        * Capacitor is a power device and Battery is an energy device * The device should be selected for a suitable solution from an overall cost performance viewpoint

      • Poster Session:PS 0205 ; Endocrinology : 31yrs. Old Young Female Presented with Weight Loss, Polyuria, Polydipsia and Hypertensive Urgency: Diagnosed to Have Malignant Phaechromocytoma

        ( Toshihiko Hata ),( Hiroyuki Sato ),( Ako Machino ),( Mai Wakabayashi ),( Morito Kise ),( Hiroki Ohashi ),( Daisuke Yamashita ),( Kaoru Sakural ),( Toru Matsubayashi ),( Masahiko Hatao ),( Ken Ueda ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        31yrs. old female known to have hypertension and dyslipidemia for 1 yr.presented with h/o weight loss around 10 kg for 1 yr,palpiations,diaphoresis and hypertensive urgencyBp 210/110 mmhg)and also found to have diabetes (newly diagnosed)further investigations shows large adrenal mass (left side)suspicion of phaechromocytoma and urine catecholamoines was high, urology was consulted and she underwent left adrenalectomy and biopsy confi rm the diagnosis of malignant phaechromcytoma. Repeat Urine catecholamines which was quite high on presentation later normalized after surgey. Now she is under active follow up with endocrinologist and on antihypertensive medications very minimal doses and for her diabetes she is not on any medications as well after surgery.

      • SCOPUSSCIEKCI등재

        A Morphologically Atypical Case of Atlantoaxial Rotatory Subluxation

        Umebayashi, Daisuke,Hara, Masahito,Nishimura, Yusuke,Wakabayashi, Toshihiko The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.55 No.5

        A rare case of atlantoaxial rotatory subluxation occurred after pediatric cervical spine surgery performed to remove a dumbbell-shaped meningioma at the level of the C1/C2 vertebrae. This case is classified as a post-surgical atlantoaxial rotatory subluxation, but has a very rare morphology that has not previously been reported. Although there are several reports about post-surgical atlantoaxial rotatory subluxation, an important point of this case is that it might be directly related to the spinal cord surgery in C1/C2 level. On day 6 after surgery, the patient presented with the Cock Robin position, and a computed tomography scan revealed a normal type of atlantoaxial rotatory subluxation. Manual reduction was performed followed by external fixation with a neck collar. About 7 months after the first surgery, the subluxation became severe, irreducible, and assumed an atypical form where the anterior tubercle of C1 migrated to a cranial position, and the posterior tubercle of C1 and the occipital bone leaned in a caudal direction. The pathogenic process suggested deformity of the occipital condyle and bilateral C2 superior facets with atlantooccipital subluxation. A second operation for reduction and fixation was performed, and the subluxation was stabilized by posterior fixation. We encountered an unusual case of a refractory subluxation that was associated with an atypical deformity of the upper spine. The case was successfully managed by posterior fixation.

      • KCI등재

        Biomechanical Analysis of a Pedicle Screw-Rod System with a Novel Cross-Link Configuration

        Yasuhiro Nakajima,Masahito Hara,Daisuke Umebayashi,Shoichi Haimoto,Yu Yamamoto,Yusuke Nishimura,Toshihiko Wakabayashi 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.6

        Study Design: The strength effects of a pedicle screw-rod system supplemented with a novel cross-link configuration were biomechanically evaluated in porcine spines. Purpose: To assess the biomechanical differences between a conventional cross-link pedicle screw-rod system versus a novel crosslink instrumentation, and to determine the effect of the cross-links. Overview of Literature: Transverse cross-link systems affect torsional rigidity, but are thought to have little impact on the sagittal motion of spinal constructs. We tested the strength effects in pullout and flexion-compression tests of novel cross-link pedicle screw constructs using porcine thoracic and lumbar vertebrae. Methods: Five matched thoracic and lumbar vertebral segments from 15 porcine spines were instrumented with 5.0-mm pedicle screws, which were then connected with 6.0-mm rods after partial corpectomy in the middle vertebral body. The forces required for construct failure in pullout and flexion-compression tests were examined in a randomized manner for three different cross-link configurations: un-cross-link control, conventional cross-link, and cross-link passing through the base of the spinous process. Statistical comparisons of strength data were analyzed using Student’s t -tests. Results: The spinous process group required a significantly greater pullout force for construct failure than the control group (p =0.036). No difference was found between the control and cross-link groups, or the cross-link and spinous process groups in pullout testing. In flexion-compression testing, the spinous processes group required significantly greater forces for construct failure than the control and cross-link groups (p <0.001 and p =0.003, respectively). However, there was no difference between the control and cross-link groups. Conclusions: A novel cross-link configuration that features cross-link devices passing through the base of the spinous processes increased the mechanical resistance in pullout and flexion-compression testing compared to un-cross-link constructs. This configuration provided more resistance to middle-column damage under flexion-compression testing than conventional cross-link configuration.

      • SCISCIESCOPUS

        Olig2 labeling index is correlated with histological and molecular classifications in low-grade diffuse gliomas.

        Suzuki, Aya,Nobusawa, Sumihito,Natsume, Atsushi,Suzuki, Hiromichi,Kim, Young-Ho,Yokoo, Hideaki,Nagaishi, Masaya,Ikota, Hayato,Nakazawa, Takuro,Wakabayashi, Toshihiko,Ohgaki, Hiroko,Nakazato, Yoichi M. Nijhoff ; Kluwer Academic Publishers 2014 Journal of neuro-oncology Vol.120 No.2

        <P>Diagnosis of low-grade diffuse gliomas based on morphology is highly subjective and, therefore, is often difficult, with significant intra- and interobserver variability. Here, we investigated WHO grade II diffuse astrocytomas, oligoastrocytomas and oligodendrogliomas for immunohistochemical expression of Olig2, measuring its labeling index (LI), and evaluated the significance of Olig2 LI in the histological and molecular classifications. The means of Olig2 LI in glioma cells were 43.7 % in diffuse astrocytomas, 59.3 % in oligoastrocytomas and 76.1 % in oligodendrogliomas. There was a statistically significant difference between all pairs of histological types. The mean of Olig2 LI of gliomas with 1p/19q loss ± IDH1/2 mutation, the majority of them being oligodendrogliomas, was significantly higher than the means of those with TP53 mutation ± IDH1/2 mutation and IDH1/2 mutation only, the majority of which were diffuse astrocytomas (70.1 vs. 47.2 and 46.5 %, respectively). When categorized according to the classification of Jiao et al., Olig2 LI of I-CF gliomas (cases with IDH and one or more of CIC, FUBP1 or combined 1p/19q loss; mean 71.0 %) was significantly higher than that of I-A gliomas (cases with IDH and ATRX alterations; mean 45.3 %). These molecular classifications were reported to correlate well with clinical outcome. However, borderlines of Olig2 LI were broad and could not clearly distinguish genotypes in the molecular classifications. In conclusion, Olig2 LI cannot be taken as a complete surrogate marker for molecular genotype, but could possibly provide some ancillary information when molecular assay is not availabe.</P>

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