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- 저자 : Thai LE (검색결과 129 건)
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Le, Thai Minh Duy,Duong, Huu Thuy Trang,Thambi, Thavasyappan,Giang Phan, V.H.,Jeong, Ji Hoon,Lee, Doo Sung American Chemical Society 2018 Biomacromolecules Vol.19 No.8
<P>Despite great potential, the delivery of genetic materials into cells or tissues of interest remains challenging owing to their susceptibility to nuclease degradation, lack of permeability to the cell membrane, and short in vivo half-life, which severely restrict their widespread use in therapeutics. To surmount these shortcomings, we developed a bioinspired in situ-forming pH- and temperature-sensitive injectable hydrogel depot that could control the delivery of DNA-bearing polyplexes for versatile biomedical applications. A series of multiblock copolymer, comprised of water-soluble poly(ethylene glycol) (PEG) and pH- and temperature-responsive poly(sulfamethazine ester urethane) (PSMEU), has been synthesized as in situ-forming injectable hydrogelators. The free-flowing PEG-PSMEU copolymer sols at high pH and room temperature (pH 8.5, 23 °C) were transformed to stable gel at the body condition (pH 7.4, 37 °C). Physical and mechanical properties of hydrogels, including their degradation rate and viscosity, are elegantly controlled by varying the composition of urethane ester units. Subcutaneous administration of free-flowing PEG-PSMEU copolymer sols to the dorsal region of Sprague-Dawley rats instantly formed hydrogel depot. The degradation of the hydrogel depot was slow at the beginning and found to be bioresorbable after two months. Cationic protein or DNA-bearing polyplex-loaded PEG-PSMEU copolymer sols formed stable gel and controlled its release over 10 days in vivo. Owing to the presence of urethane linkages, the PEG-PSMEU possesses excellent adhesion strength to wide range of surfaces including glass, plastic, and fresh organs. More importantly, the hydrogels effectively adhered on human skin and peeled easily without eliciting an inflammatory response. Subcutaneous implantation of PEG-PSMEU copolymer sols effectively sealed the ruptured skin, which accelerated the wound healing process as observed by the skin appendage morphogenesis. The bioinspired in situ-forming pH- and temperature-sensitive injectable adhesive hydrogel may provide a promising platform for myriad biomedical applications as controlled delivery vehicle, adhesive, and tissue regeneration.</P> [FIG OMISSION]</BR>
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Examining the Non-Linear Impact of External Debt on Economic Convergence
Thai Hong Le,Lan Trinh Thi Phan 세종대학교 경제통합연구소 2022 Journal of Economic Integration Vol.37 No.3
This article investigates the impact of external debt on economic convergence in 201 economies from 1990 to 2020. Panel data collected from the fiscal space database of the World Bank are analyzed using the conditional beta convergence framework. Results show that external debt negatively affects growth and there is no evidence to support the non-linear association. However, external debt influences the convergence speed in an inverted-U-shaped fashion. The economic convergence speeds up as the level of indebtedness increases to a threshold above which the convergence slows down as the level of foreign debts continues to increase. We also disaggregate external debt into its six sub-components and discover the non-linear effects of private debts and debts denominated in domestic currency on the convergence process.
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Spanwise coherent structure of wind turbulence and induced pressure on rectangular cylinders
Le, Thai-Hoa,Matsumoto, Masaru,Shirato, Hiromichi Techno-Press 2009 Wind and Structures, An International Journal (WAS Vol.12 No.5
Studying the spatial distribution in coherent fields such as turbulence and turbulence-induced force is important to model and evaluate turbulence-induced forces and response of structures in the turbulent flows. Turbulence field-based coherence function is commonly used for the spatial distribution characteristic of the turbulence-induced forces in the frequency domain so far. This paper will focus to study spectral coherent structure of the turbulence and induced forces in not only the frequency domain using conventional Fourier transform-based coherence, but also temporo-spectral coherence one in the time-frequency plane thanks to wavelet transform-based coherence for better understanding of the turbulence and force coherences and their spatial distributions. Effects of spanwise separations, bluff body flow, flow conditions and Karman vortex on coherent structures of the turbulence and induced pressure, comparison between turbulence and pressure coherences as well as intermittency of the coherent structure in the time-frequency plane will be investigated here. Some new findings are that not only the force coherence is higher than the turbulence coherence, the coherences of turbulence and forces depend on the spanwise separation as previous studies, but also the coherent structures of turbulence and forces relate to the ongoing turbulence flow and bluff body flow, moreover, intermittency in the time domain and low spectral band is considered as the nature of the coherent structure. Simultaneous measurements of the surface pressure and turbulence have been carried out on some typical rectangular cylinders with slenderness ratios B/D=1 (without and with splitter plate) and B/D=5 under the artificial turbulent flows in the wind tunnel.
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Spanwise coherent structure of wind turbulence and induced pressure on rectangular cylinders
Thai-Hoa Le,Masaru Matsumoto,Hiromichi Shirato 한국풍공학회 2009 Wind and Structures, An International Journal (WAS Vol.12 No.5
Studying the spatial distribution in coherent fields such as turbulence and turbulence-induced force is important to model and evaluate turbulence-induced forces and response of structures in the turbulent flows. Turbulence field-based coherence function is commonly used for the spatial distribution characteristic of the turbulence-induced forces in the frequency domain so far. This paper will focus to study spectral coherent structure of the turbulence and induced forces in not only the frequency domain using conventional Fourier transform-based coherence, but also temporo-spectral coherence one in the timefrequency plane thanks to wavelet transform-based coherence for better understanding of the turbulence and force coherences and their spatial distributions. Effects of spanwise separations, bluff body flow, flow conditions and Karman vortex on coherent structures of the turbulence and induced pressure, comparison between turbulence and pressure coherences as well as intermittency of the coherent structure in the timefrequency plane will be investigated here. Some new findings are that not only the force coherence is higher than the turbulence coherence, the coherences of turbulence and forces depend on the spanwise separation as previous studies, but also the coherent structures of turbulence and forces relate to the ongoing turbulence flow and bluff body flow, moreover, intermittency in the time domain and low spectral band is considered as the nature of the coherent structure. Simultaneous measurements of the surface pressure and turbulence have been carried out on some typical rectangular cylinders with slenderness ratios B/D=1 (without and with splitter plate) and B/D=5 under the artificial turbulent flows in the wind tunnel.
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Rectangular prism pressure coherence by modified Morlet continuous wavelet transform
Thai-Hoa Le,Luca Caracoglia 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.20 No.5
This study investigates the use of time-frequency coherence analysis for detecting and evaluating coherent “structures” of surface pressures and wind turbulence components, simultaneously on the time-frequency plane. The continuous wavelet transform-based coherence is employed in this time-frequency examination since it enables multi-resolution analysis of non-stationary signals. The wavelet coherence quantity is used to identify highly coherent “events” and the “coherent structure” of both wind turbulence components and surface pressures on rectangular prisms, which are measured experimentally. The study also examines, by proposing a “modified” complex Morlet wavelet function, the influence of the time-frequency resolution and wavelet parameters (i.e., central frequency and bandwidth) on the wavelet coherence of the surface pressures. It is found that the time-frequency resolution may significantly affect the accuracy of the time-frequency coherence; the selection of the central frequency in the modified complex Morlet wavelet is the key parameter for the time-frequency resolution analysis. Furthermore, the concepts of time-averaged wavelet coherence and wavelet coherence ridge are used to better investigate the time-frequency coherence, the coherently dominant events and the time-varying coherence distribution. Experimental data derived from physical measurements of turbulent flow and surface pressures on rectangular prisms with slenderness ratios B/D=1:1 and B/D=5:1, are analyzed.
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Rectangular prism pressure coherence by modified Morlet continuous wavelet transform
Le, Thai-Hoa,Caracoglia, Luca Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.20 No.5
This study investigates the use of time-frequency coherence analysis for detecting and evaluating coherent "structures" of surface pressures and wind turbulence components, simultaneously on the time-frequency plane. The continuous wavelet transform-based coherence is employed in this time-frequency examination since it enables multi-resolution analysis of non-stationary signals. The wavelet coherence quantity is used to identify highly coherent "events" and the "coherent structure" of both wind turbulence components and surface pressures on rectangular prisms, which are measured experimentally. The study also examines, by proposing a "modified" complex Morlet wavelet function, the influence of the time-frequency resolution and wavelet parameters (i.e., central frequency and bandwidth) on the wavelet coherence of the surface pressures. It is found that the time-frequency resolution may significantly affect the accuracy of the time-frequency coherence; the selection of the central frequency in the modified complex Morlet wavelet is the key parameter for the time-frequency resolution analysis. Furthermore, the concepts of time-averaged wavelet coherence and wavelet coherence ridge are used to better investigate the time-frequency coherence, the coherently dominant events and the time-varying coherence distribution. Experimental data derived from physical measurements of turbulent flow and surface pressures on rectangular prisms with slenderness ratios B/D=1:1 and B/D=5:1, are analyzed.
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