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Development of Low Voltage 2 Level IGBT Inverter and Converter for Industrial Applications
Tetsuya Okamoto,Yusuke Ishida,Yoshihito Kato,S. Miyazaki 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
This paper presents a new IGBT based AC drive inverter and its DC source converter, which were developed for industrial applications. AC drive inverter provides some benefits to customer, very large capacity for an induction motor, a compact footprint and a secured safety stop sequence which is compliant with ISO/IEC functional safety standard. And DC source converter to supply DC input power to AC drive system also provides some benefits as same as AC drive inverter. In addition, it is expected that new PWM control “Instantaneous Current Control PWM (IccPWM)” can improve performance to suppress a harmful harmonics against other surrounding devices and provide a simple harmonic filter to comply with IEEE-519 harmonic limits.
( Toshiyuki Sato ),( Tetsuya Takagawa ),( Yoichi Kakuta ),( Akihiro Nishio ),( Mikio Kawai ),( Koji Kamikozuru ),( Yoko Yokoyama ),( Yuko Kita ),( Takako Miyazaki ),( Masaki Iimuro ),( Nobuyuki Hida ) 대한장연구학회 2017 Intestinal Research Vol.15 No.3
Background/Aims: Recent genome-wide analyses have provided strong evidence concerning adverse events caused by thiopurine drugs such as azathioprine (AZA) and 6-mercaptopurine. The strong associations identified between NUDT15 p.Arg139Cys and thiopurine-induced leukopenia and severe hair loss have been studied and confirmed over the last 2 years. However, other coding variants, including NUDT15 p.Val18_Val19insGlyVal, NUDT15 p.Val18Ile, and FTO p.Ala134Thr, and a noncoding variation in RUNX1 (rs2834826) remain to be examined in detail in this respect. Therefore, we investigated the correlation between these adverse events and the 5 recently identified variants mentioned above among Japanese patients with inflammatory bowel diseases (IBD). Methods: One hundred sixty thiopurine-treated patients with IBD were enrolled. Genotyping was performed using TaqMan SNP Genotyping Assays or Sanger sequencing. Results: None of the 5 variants were associated with gastrointestinal intolerance to AZA. However, NUDT15 p.Arg139Cys was significantly associated with the interval between initiation and discontinuation of AZA among patients with gastrointestinal intolerance. This variant was strongly associated with early (<8 weeks) and late (≥8 weeks) leukopenia and severe hair loss. Moreover, it correlated with the interval between initiation of thiopurine therapy and leukopenia occurrence, and average thiopurine dose. NUDT15 p.Val18_Val19insGlyVal, NUDT15 p.Val18Ile, FTO p.Ala134Thr, and RUNX1 rs2834826 exhibited no significant relationship with the adverse events examined. Conclusions: Of the 5 variants investigated, NUDT15 p.Arg139Cys had the strongest impact on thiopurineinduced leukopenia and severe hair loss; therefore, its genotyping should be prioritized over that of other variants in efforts to predict these adverse events in Japanese patients with IBD. (Intest Res 2017;15:328-337)
Tetsuta Kubo,Tetsuya K. Matsumoto,Yuko Miyazaki,Okihito Yano 국립중앙과학관 2024 Journal of Asia-Pacific Biodiversity Vol.17 No.1
Effective pollinators of Arisaema nambae Kitam., endemic to western Okayama and eastern Hiroshimaprefectures, western Japan, were determined, and 113 insects from 24 spathes of A. nambae in threepopulations in Okayama Prefecture were collected. Most floral visitors were fungus gnats (Mycetophi lidae and Sciaridae). Their maximum body width was less than the internal diameter (ca. 2 mm) of theexit at the bottom of the staminate spathe. Pollen grains of Arisaema attached to the bodies of fungusgnats collected from pistillate spathes provided evidence that they visited the pistillate spathe afterescaping from staminate spathes. Based on their visitation frequency, size compatibility between theirbody and the exit from the staminate spathes and the pollen loads they carry, fungus gnats appear to playan important role in the pollination of A. nambae.
Taguchi, Satoru,Fukuhara, Hiroshi,Kakutani, Shigenori,Takeshima, Yuta,Miyazaki, Hideyo,Suzuki, Motofumi,Fujimura, Tetsuya,Nakagawa, Tohru,Igawa, Yasuhiko,Kume, Haruki,Homma, Yukio Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Background: Adjuvant androgen deprivation therapy (ADT) is a treatment option for prostate cancer (PC) patients after radical prostatectomy (RP). Although it can achieve a good progression-free survival rate, some patients still develop clinical metastasis. We here investigated risk factors of clinical metastasis in post-prostatectomy patients who received immediate adjuvant ADT. Materials and Methods: We identified 197 patients with non-metastatic PC who underwent RP at our institution between 2000 and 2012, followed by adjuvant ADT. The associations of various clinicopathologic factors with clinical metastasis (primary endpoint) and cancer-specific survival (secondary endpoint) were assessed. Multivariate analysis was conducted using a Cox proportional hazards model. Median follow-up was 87 months after RP. Results: Nine (4.6%) patients developed clinical metastasis and six (3.0%) died from PC. Eight of nine metastatic patients had a pathologic Gleason score (GS) 9 and developed bone metastasis, while the remaining one had pathologic GS 7 and developed metastasis only to para-aortic lymph nodes. On multivariate analyses, pathologic GS ${\geq}9$ and regional lymph node metastasis (pN1) were independent predictors of clinical metastasis and pathologic GS ${\geq}9$ was an independent predictor of cancer-specific death. Conclusions: Pathologic GS ${\geq}9$ and pN1 were independent predictors of clinical metastasis in post-prostatectomy patients who received immediate adjuvant ADT. Furthermore, pathologic GS ${\geq}9$ was an indispensable condition for bone metastasis, which may imply that patients with GS ${\leq}8$ on adjuvant ADT are unlikely to develop bone metastasis.