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Yuping Zhu,Suzhen Zhai,Bei Li,Ziyi Zhao,Jiao Xie,Tingyuan Ren 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.11
To explore hypoglycemic effect of wild Rosa roxburghii tratt (RRT) juice at different altitudes on type 1diabetes mellitus (T1DM). The T1DM mouse model was induced by streptozotocin (STZ), and the experiment included anormal group (NC), model group (MC), wild RRT juice groups high (HF), medium (MF), low altitude (DF) and cultivatedcontrol group (PC). During experiment, food intake, water intake, body weight, and fasting blood glucose were measured. After 28 days of administration, glucose tolerance, glycogen level, lipid profiles, and antioxidation levels in serum and liverwere measured, and histomorphological changes of liver and kidney were observed by hematoxylin and eosin staining. The results showed that wild RRT juice reduced blood glucose level, alleviated liver and kidney tissue damage, improvedglucose and lipid metabolism disorders and attenuated oxidative damage in T1DM mice. Western blot showed that wild RRTjuice at grown at different altitudes significantly increased protein abundance of PI3K, Akt, and GLUT2 in liver of T1DMmice. In conclusion, wild RRT juice from different altitudes improved glucose and lipid metabolism disorders and oxidativedamage in T1DM mice, which may be attributed to activation of PI3K/Akt pathway. Overall effect: MF > PC > HF > DF.
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Molecular simulation of adsorption of NO and CO2 mixtures by a Cu-BTC metal organic framework
Guanghao Meng,Xuedan Song,Min Ji,Juanyuan Hao,Yantao Shi,Suzhen Ren,Jieshan Qiu,Ce Hao 한국물리학회 2015 Current Applied Physics Vol.15 No.9
Environmental problems due to the discharge of gases, including NO and CO2, in addition, diseases caused by improper concentration of NO and CO2 in vivo must be resolved. In this study, Grand canonical Monte Carlo (GCMC) simulations are combined with density functional theory (DFT) to calculate the adsorption of NO and CO2 from a dual-component mixture to the Cu-BTC metal organic framework. The results show that the adsorption isotherms for various molar ratios of the gaseous mixture followed a Langmuir distribution. At higher pressures more CO2 than NO was adsorbed by Cu-BTC, with NO showing a tendency to desorb. However, better results for adsorption of NO were observed at lower pressures. For the different pressure and molar ratios of the gaseous mixture examined, more CO2 than NO was always adsorbed. Compared with three-way catalysts, Cu-BTC offers benefits to adsorption of CO2 and NO from gaseous mixtures without increased durability problems.
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