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Yoon, Hyonok,Kim, Do-Sung,Lee, Geum-Hwa,Kim, Ji Ye,Kim, Diana H,Kim, Kee-Won,Chae, Soo-Wan,You, Wan-Hee,Lee, Yong Chul,Park, Seoung Ju,Kim, Hyung-Ryong,Chae, Han-Jung Pharmaceutical Society of Great Britain 2009 Journal of pharmacy and pharmacology Vol.61 No.11
<P>OBJECTIVES: This study tested whether sodium para-amino salicylic dihydrate, an antibacterial drug for tuberculosis, could block manganese-induced apoptosis in SK-N-MC neurons. METHODS: Cell viability, Hoechst staining, dichlorofluorescin diacetate analysis for reactive oxygen species measurement, and immunoblotting were performed. KEY FINDINGS: In vitro, manganese chloride significantly decreased the viability of SK-N-MC cells, accompanied by apoptotic features such as changes in nuclear morphology. Sodium para-amino salicylic dihydrate inhibited these apoptotic characteristics through reducing intracellular reactive oxygen species generation, protecting mitochondrial membrane potential and caspase-3 activation. CONCLUSIONS: Sodium para-amino salicylic dihydrate inhibits manganese-induced apoptosis in neurons and may reduce manganese-mediated neurodegeneration.</P>
Sung, Kew Yong,Jeon, Wook,Jung, Yoon,Lim, Jeong Eun,Uhm, H.S.,Choi, Eun Ha Institute of Electrical and Electronics Engineers 2005 IEEE transactions on plasma science Vol.33 No.4
We have investigated the influence of anode-cathode (A-K) gap distance on the output characteristics of high-power microwave from coaxial virtual cathode oscillator (vircator). This high-power microwave generator is powered by the "Chundoong" (Max 600 kV, 88 kA, 60 ns), which is an intense relativistic electron beam-pulse generator. In this experiment, it was observed that the microwave power has been strongly dependent upon the A-K gap distance, where the A-K gap has been varied from 4 to 8 mm. The maximum microwave power is observed to be 244 MW, whose efficiency is about 2.75% at the A-K gap distance 4 mm. Also the microwave frequencies are measured to be 5.1⩽f⩽5.9 GHz from the combination of a coupled line band pass filter with a 1-GHz bandwidth and dispersive delay line method. It is noted that measured output microwave frequency is in good agreement with that of simulation. It is also found that the dominant mode of output microwave is a TM<SUB>01</SUB> in this simulation result.
Yoon, Jung H,Choi, Sung S,Kim, Olga,Choi, Won S,Park, Yong K,Nam, Suk W,Lee, Jung Y,Park, Won S Springer Science and Business Media LLC 2016 Modern pathology Vol.29 No.2
<P>Intestinal metaplasia in gastric mucosa is considered a preneoplastic lesion that progresses to gastric cancer. However, the molecular networks underlying this lesion formation are largely unknown. NKX6.3 is known to be an important regulator in gastric mucosal epithelial differentiation. In this study, we characterized the effects of NKX6.3 that may contribute to gastric intestinal metaplasia. NKX6.3 expression was significantly reduced in gastric mucosae with intestinal metaplasia. The mRNA expression levels of both NKX6.3 and CDX2 predicted the intestinal metaplasia risk, with an area under the receiver operating characteristic curve value of 0.9414 and 0.9971, respectively. Notably, the NKX6.3 expression level was positively and inversely correlated with SOX2 and CDX2, respectively. In stable AGS(NKX6.3) and MKN1(NKX6.3) cells, NKX6.3 regulated the expression of CDX2 and SOX2 by directly binding to the promoter regions of both genes. Nuclear NKX6.3 expression was detected only in gastric epithelial cells without intestinal metaplasia. Furthermore, NKX6.3-induced TWSG1 bound to BMP4 and inhibited BMP4-binding activity to BMPR-II. These data suggest that NKX6.3 might function as a master regulator of gastric differentiation by affecting SOX2 and CDX2 expression and the NKX6.3 inactivation may result in intestinal metaplasia in gastric epithelial cells.</P>
Lim, Yong-Sik,Nugraha, Ahmad R. T.,Cho, Sung-Jae,Noh, Min-Young,Yoon, Eun-Jin,Liu, Huaping,Kim, Ji-Hee,Telg, Hagen,Há,roz, Erik H.,Sanders, Gary D.,Baik, Sung-Hoon,Kataura, Hiromichi,Doorn, Step American Chemical Society 2014 NANO LETTERS Vol.14 No.3
<P>Using a macroscopic ensemble of highly enriched (6,5) single-wall carbon nanotubes, combined with high signal-to-noise ratio and time-dependent differential transmission spectroscopy, we have generated vibrational modes in an ultrawide spectral range (10–3000 cm<SUP>–1</SUP>). A total of 14 modes were clearly resolved and identified, including fundamental modes of A, E<SUB>1</SUB>, and E<SUB>2</SUB> symmetries and their combinational modes involving two and three phonons. Through comparison with continuous wave Raman spectra as well as calculations based on an extended tight-binding model, we were able to identify all the observed peaks and determine the frequencies of the individual and combined modes. We provide a full summary of phonon frequencies for (6,5) nanotubes that can serve as a basic reference with which to refine our understanding of nanotube phonon spectra as well as a testbed for new theoretical models.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2014/nalefd.2014.14.issue-3/nl404536b/production/images/medium/nl-2013-04536b_0005.gif'></P>
Impact of Pyrazinamide Usage on Serious Adverse Events in Elderly Tuberculosis Patients
( Joonyoung Yoon ),( Yong-soo Kwon ),( Jinsoo Min ),( Ju Sang Kim ),( Hyung Woo Kim ),( Yong Hyun Kim ),( Sung Soo Jeong ),( Jee Youn Oh ),( Jin Woo Kim ),( Sang Haak Lee ),( Sung Kyoung Kim ),( Sun-h 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0
Breeding of the Korean Native Bumblebee, Bombus ignitus
Hyung Joo Yoon,Kyeong Yong Lee,Mi Ae Kim,Sang Mi Han,In Gyun Park 한국응용곤충학회 2012 한국응용곤충학회 학술대회논문집 Vol.2012 No.10
Many bumblebee species have declined in number in recent decades, particularly in developing regions. Widespread declines of bumblebee species threaten the pollination levels of both wildflowers and crops. Here, we investigated the body weight and colony-developmental characteristics of Korean native bumblebee (B. ignitus) queens collected from 2000 to 2010 for conservation of native bumblebees for breeding. The average weight of 6,852 queens was 0.77 ± 0.44 g. The weight of B. ignitus queens collected in 2005 was the greatest, 0.87 ± 0.12 g, which was 1.0–1.3-fold heavier than any other year. The average oviposition rate was 81.6 ± 10.7%, and 2004 showed the highest rate, 95.0%. This value corresponded to 1.1-1.6-fold increases over the queens collected in the other years. The average rate of colony foundation was 60.9 ± 11.0%. Queens in 2008 exhibited the best performance, 75.4%, which was 1.0-1.9-fold higher than the other years. The rate of progeny-queen production averaged 27.0 ± 9.4% (Fig. 5) and peaked in 2001 at 43.2%; this value was 1.1–4.7-fold higher than other years. The average number of queens produced and number of generations begotten by queens was 27.6 ± 10.1% and 4.8 ± 2.0, respectively. Queens in 2000 averaged 9 generations of offspring, which was 1.1-3.1-fold greater than other years. These results indicate that the colony-developmental characteristics of the collected queens changed significantly between 2000 and 2010. In addition, there was no correlation between body weight and number of queens collected, although body weight was affected by collection year. Since 2008, the colony- developmental characteristics of queens have worsened.
YOO, KWANG H.,KIM, YOUNG S.,SHEEN, SEUNG S.,PARK, JOO H.,HWANG, YONG I.,KIM, SANG‐,HA,YOON, HO I.,LIM, SUNG C.,PARK, JAE Y.,PARK, SEOUNG J.,SEO, KI H.,KIM, KI U.,OH, YEON‐,MOK,LEE, NA Y.,K Blackwell Publishing Asia 2011 Respirology Vol.16 No.4
<P><B>ABSTRACT</B></P><P><B>Background and objective: </B> Because the mortality and social burden associated with COPD is increasing, repeated surveys of the prevalence of COPD have been used to assess risk factors, detect potential patients, and establish early diagnoses and management protocols. We report the prevalence of spirometrically detected COPD in Korea in 2008, using data from the fourth Korean National Health and Nutrition Survey.</P><P><B>Methods: </B> Using nationwide stratified random sampling, based on the Korean Statistical Office census, 6840 subjects aged ≥19 years underwent spirometry, which was performed by four trained technicians, during 2008. The place of residence, levels of education and income and smoking status, as well as other results from a COPD survey questionnaire were also assessed.</P><P><B>Results: </B> Airflow obstruction (FEV<SUB>1</SUB>/FVC < 0.7) was detected in 8.8% of subjects aged ≥19 years (11.6% of men and 5.9% of women) and COPD was detected in 13.4% of subjects aged ≥40 years (19.4% of men and 7.9% of women). Of the 6840 subjects, 27.3% were current smokers and 17.2% were former smokers, and the prevalence of COPD was higher in current and former smokers than in never smokers. Approximately 94% of patients with COPD had mild‐to‐moderate disease, without apparent symptoms; only 2.4% had been diagnosed by a physician and only 2.1% of patients had been treated. The independent risk factors for COPD were smoking, advanced age and male gender.</P><P><B>Conclusions: </B> Although the prevalence of COPD in Korea is high, the disease is underdiagnosed and most COPD patients are under‐treated.</P>