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서기석,이진우,김상태 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1
Verrucous mycosis fungoides is very rare variant of cutaneous T cell lymphoma that manifests verrucous crusted lesion and may be clinically misdiagnosed as a wart, deep fungal infection or atypical mycobacterial infection. If it is located acrally, it might then be better classified as mycosis fungoides palmaris et plantaris or pagetoid reticulosis. We report a case of solitary verrucous mycosis fungoides on the left knee in 25-year-old woman successfully treated ultraviolet A-1 phototherapy.
Efficacy of Ultraviolet A1 Phototherapy in Recalcitrant Skin Diseases
( Kee Suck Suh ),( Jin Seuk Kang ),( Jae Woo Baek ),( Tae Kwon Kim ),( Jin Woo Lee ),( Young Seung Jeon ),( Min Soo Jang ),( Sang Tae Kim ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.1
Background: Ultraviolet (UV) radiation has been used for decades to treat a variety of skin diseases. UVA1 was used initially as an effective treatment for acute exacerbated atopic dermatitis. Since then, UVA1 has been attempted for recalcitrant skin diseases. Objective: This study examined the efficacy of UVA1 phototherapy in three recalcitrant skin diseases. Methods: This retrospective study reviewed the efficacy and follow-up of 26 patients with atopic dermatitis (AD), mycosis fungoides (MF) and localized scleroderma (LS). SUPUVASUN 3000 (Mutzhas Co., Munich, Germany) and SELLAMED 3000 (Sellas Medizinische Gerate GmbH, Gevelsberg, Germany) were the UVA1 equipment used. Irradiation was performed in accordance with the disease. Low-dose (20 J/cm2), medium-dose (65 J/cm2) and high-dose regimens (100 J/cm2) of UVA1 therapy were employed. The frequency of the therapy ranged from 3 to 5 times weekly. The therapeutic effectiveness was assessed according to the clinical examination before and after the last treatment. Results: In patients with AD, complete and partial remission was achieved in four (80%) and one (20%) patient, respectively. In patients with MF, complete and partial remission was observed in thirteen (86.7%) and two (13.3%) patients, respectively. In patients with LS, complete and partial remission was observed in three (50%) and three (50%) patients, respectively. Conclusion: UVA1 phototherapy is an effective treatment modality for acute exacerbated AD, MF and LS. (Ann Dermatol 22(1) 1∼8, 2010)
Hur, Jin,Yoon, Choon-Sik,Ryu, Young Hoon,Yun, Mi Jin,Suh, Jin-Suck Lippincott Williams Wilkins, Inc. 2007 Journal of computer assisted tomography Vol.31 No.5
PURPOSE:: The aim of this study was to compare the accuracy of fluorodeoxyglucose-positron emission tomography (FDG-PET) with bone scan for diagnosis of single bone metastasis using a semiquantitative method. MATERIAL AND METHODS:: Seventy-six patients with suspected single bone metastasis, who underwent both FDG-PET and a bone scan, were selected. The number and location of lesions detected upon both FDG-PET and bone scan were recorded, and the lesions were compared using the McNemar test. For semiquantitative analysis, a maximum (max) standard uptake value (SUV) of 2.5 was used as the positive cutoff value for metastasis. The difference in max SUV value among 3 groups (osteolytic, osteoblastic, and benign lesions) was assessed using the Student-Newman-Keuls method. Biopsy results, other imaging findings (multirow detector computed tomography, magnetic resonance imaging), and the patient's clinical course were used as references. RESULTS:: There were 47 single bone metastases and 29 benign lesions. The sensitivity, specificity, and accuracy of bone scans for diagnosing bone metastases were 89%, 41%, and 71%, respectively, and those of FDG-PET were 85%, 52%, and 72%, respectively. These data were not significantly different (P > 0.05). Using a max SUV of 2.5 as the positive cutoff value for metastasis, the specificity and accuracy of FDG-PET, 83% for each, improved. When classifying bone metastasis as osteoblastic or osteolytic, the max SUV was significantly higher in osteolytic metastasis than in osteoblastic and benign lesions (P = 0.001). CONCLUSIONS:: Fluorodeoxyglucose-positron emission tomography (FDG-PET) using the semiquantitative parameter SUV improves the diagnostic ability to differentiate between single bone metastases and benign lesions.
The Inhibitory Effect of Phytoclear-EL1 on Melanogenesis
( Kee Suck Suh ),( Jae Woo Baek ),( Tae Kwon Kim ),( Jin Woo Lee ),( Hyo Jin Roh ),( Young Seung Jeon ),( Sang Tae Kim ) 대한피부과학회 2009 Annals of Dermatology Vol.21 No.4
Background: Phytoclear-EL1, an extract from Euphorbia lathyris seeds, has a whitening effect due to inhibition of tyrosinase activity. Objective: The purpose of this study was to investigate the inhibitory effect of phytoclear-EL1 on melanogenesis. Methods: Cultured B-16 melanoma cells and 30 human volunteers were used for in vitro and in vivo studies, respectively. Phytoclear-EL1 was added to the cultured B-16 melanoma cells, and applied to UVB-induced hyperpigmented lesions of human volunteers twice daily for 7 weeks. Changes in the number of B-16 melanoma cells, as well as changes in morphology, melanin content, and tyrosinase activity, were measured and then compared with the normal control and the 10-3M arbutin groups. Also, the effect of phytoclear-EL1 on UVB-induced hyperpigmented lesions was examined through subjective and objective measurements. Results: In the in vitro study (p<0.05), the number, melanin content, and tyrosinase activity of cultured B-16 melanoma cells were decreased in the 5 μg/ml phytoclear-EL1 group compared to the control group. On objective assessment with a chromameter, the 0.2% phytoclear-EL1 group had a larger difference in the mean L values before and 7 weeks after applying phytoclear-EL1 as compared to the other groups. On subjective assessment by both the researchers and subjects 7 weeks after applying experimental materials, the 0.2% phytoclear-EL1 group and positive control (3% arbutin) had higher scores than the placebo groups. These results demonstrated that phytoclear-EL1 in vivo and in vitro had an inhibitory effect on melanogenesis. Conclusion: Phytoclear-EL1 may be a candidate extract in the control of hyperpigmentary disorders. (Ann Dermatol 21(4) 369~375, 2009)
Granulocyte Colony-Stimulating Factor (G-CSF) 투여 후 비정형 골수세포와 혈관염을 보인 약진
서기석 ( Kee Suck Suh ),이진우 ( Jin Woo Lee ),노효진 ( Hyo Jin Roh ),최수영 ( Soo Young Choi ),도기승 ( Ki Seung Doh ),김상태 ( Sang Tae Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.10
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor (HGF) with many applications in cancer therapy. Many cutaneous adverse reactions associated with G-CSF have been reported in recent years, including injection site reactions, pyoderma gangrenosum, Sweet`s syndrome, cutaneous leukocytoclastic vasculitis, and widespread folliculitis. We report a case of vasculitis with atypical myeloid cell induced by G-CSF on the lower extremities (Korean J Dermatol 2007;45(10):1078∼1082)
서기석 ( Kee Suck Suh ),이진우 ( Jin Woo Lee ),노효진 ( Hyo Jin Roh ),최수영 ( Soo Young Choi ),도기승 ( Ki Seung Doh ),김상태 ( Sang Tae Kim ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.8
Palmoplantar lichen planus is a rare, localized variant of the disease that may create difficulty in diagnosis if it is present as an isolated finding. As palmoplantar lichen planus do not usually have the classically clinical features of lichen planus, a biopsy is very useful. Histopathologic findings are identical to classic lichen planus. According to literature, similar lichen planus may be found elsewhere on the body in palmoplantar lichen planus. We report a case of lichen planus limited to the soles in a 50 year-old female, who presents with erythematous hyperkeratotic crusted pruritic plaques on both soles. (Korean J Dermatol 2007;45(8):855∼857)
서기석 ( Kee Suck Suh ),이진우 ( Jin Woo Lee ),노효진 ( Hyo Jin Roh ),최수영 ( Soo Young Choi ),도기승 ( Ki Seung Doh ),김상태 ( Sang Tae Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.1
Morphea is a rare, sclerotic connective tissue disorder and is thought to be caused by a decreased collagenase activity. Numerous treatment modalities have been tried, such as infiltration with glucocorticosteroid, D-penicillamine, antimalarial agents and cyclosporine. However, all have shown only limited success. We report a case of a 21 year-old female with localized scleroderma, who showed a marked improvement after localized therapy with high dose UVA-1. (Korean J Dermatol 2007;45(1):76~78)