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RISS 인기검색어
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- 저자 : Sudhanshu Sharma (검색결과 3 건)
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Vijay Mandal,Shashank Sharma,Sudhanshu S. Singh,J. Ramkumar 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.1
Laser surface texturing can improve the surface properties of the metallic components. In this work, surface texturing hasbeen carried in a powder bed fusion of Inconel 718 (IN718) rather than material removal process. A 2D fnite element method(FEM) has been built to simulate the thermo-fuidic dynamics of surface texturing, incorporating the phase-feld method inthe preplaced IN718 powder. The temperature and induced velocity felds have been predicted using transient heat transferand fuid fow based on the conservation of mass, momentum, and energy in the melt pool. Furthermore, the roles of drivingforces such as Marangoni force, recoil pressure, and thermal buoyancy force on the melt pool behavior have been evaluated. Micro-textures were developed using laser on the powder bed by using diferent scanning patterns, such as line, circle, hatchand convex dimple. The efect of process parameters (pitch distance, number of pulses and number of layers) on the surfacehydrophobicity were evaluated by measuring the contact angle, where the convex dimple texture exhibited the maximumcontact angle. The hydrophobicity was afected by the ripples (2nd level of roughness) on the surface, which increased withan increase in number of pulses.
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Sadashiv,Anupama Modi,Manoj Khokhar,Praveen Sharma,Rajnish Joshi,Sudhanshu Shekhar Mishra,Rajay N Bharshankar,Sunita Tiwari,Pankaj Kumar Singh,Vivek Vidyadhar Bhosale,Mahendra Pal Singh Negi 대한비만학회 2021 The Korean journal of obesity Vol.30 No.3
Background: It is well established that obesity is a major health risk in diabetes and associated diseases. Epigenetic changes, specially DNA methylation, play an important role in regulation of adipokines. The objective of the present study was to evaluate the DNA methylation status at the promoter region of the leptin gene in obese individuals and its association with metabolic risk factors. Methods: The study included obese (n=100) and non-obese (n=75) individuals aged 25–45 years, and measured their physical, biochemical parameters (glucose, insulin, and lipid profiles) and leptin, DNA methyltransferase 1 (DNMT1), and DNA methyltransferase 3 beta (DNMT3b) mRNA expressions with real-time reverse transcription-polymerase chain reaction (qRT-PCR). DNA methylation of the leptin gene at the promoter region was analyzed by methyl-specific qPCR . Results: The study found that the DNA methylation level at the promoter area of the leptin gene was negatively associated with weight in obese subjects. Furthermore, study findings showed that the DNA methylation level was negatively associated with fasting insulin, glucose, homeostatic model assessment for insulin resistance, and total cholesterol. There was also a higher expression of DNMT1 and DNMT-3b in obese subjects as compared with non-obese subjects. Conclusion: The leptin epigenetic profile may be associated with obesity and its associated metabolic risk factors.
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Understanding the electrocatalysis OER and ORR activity of ultrathin spinel Mn3O4
Chinmayee Chowde Gowda,Ankita Mathur,Arko Parui,Partha Kumbhakar,Prafull Pandey,Sudhanshu Sharma,Amreesh Chandra,Abhishek K. Singh,Aditi Halder,Chandra Sekhar Tiwary 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.113 No.-
Rapid depletion of non-renewable sources has made us look into possible green energy alternatives tomeet energy challenges. Electrocatalytic reactions involving oxygen evolution reaction (OER) and oxygenreduction reaction (ORR) play crucial roles in assisting the derivation of clean forms of energy. Here, wedemonstrate that few layers of the manganese oxide: hausmannitene (atomically thin two dimensional(2D-Mn3O4) can be exfoliated from its bulk form hausmannite (Mn3O4). Most significantly, the hausmanniteneexhibits catalytic activity towards oxygen reduction and evolution reactions. The hausmannitenehas enhanced Mn(III) ions (65%) compared to its parent structure hausmannite (31%). The Mn(III) ionsin a distorted lattice show the highest catalytic activity towards OER performance with the oxygen electrodeactivity (DE) of 1.08 eV for hausmannitene. The density functional theory (DFT) calculations, confirmedthe presence of both Mn(III) and Mn(II) sites on the (112)-oriented surface of Mn3O4 which arehighly active for OER and ORR, having vacant and filled orbitals of lowest and highest energy, respectively. Increased oxidation sites aiding to better performance of 2D structure was theoretically manifested. Therefore, demonstrating that similar mechanisms can be used to explore other 2D oxides aspossible efficient stable electrocatalyst substitute for energy conversion.
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