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Metal Oxide Sensor Array를 이용한 사과와 귤의 신선도 분석
임향주,한도수,조성동,김기윤 조선대학교 기초과학연구소 2000 自然科學硏究 Vol.23 No.1
The Electronic Nose has been designed to provide objective and reproducible aroma discrimination on a wide variety to human nose. The sensor array in combination with sophisticated chemometrics and artificial neural network software provides the output displaying the closeness of difference in aroma patterns of different samples. As an application the system has been used to discriminate of the fresh and decomposing apples and oranges. The discrimination has been successfully demonstrated.
나경민,한호석,예수향,김현구 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.5
The present study was conducted to investigate extraction characteristics and antioxidative activity of Cassia tora L. extracts, Casia tora L. was extracted by reflux extraction under different extraction conditions including solvent. The solid yield, turbidity, color value, titratable acidity, free sugar contents, electron donating ability and superoxide dismutase-like ability of Cassia tora L. extracts were determined. The highest solid yield value was obtained with water of 10 fold. No significant difference in turbidity and color value were found among the extracts prepared with various extraction solvents, 75% ethanol, 50% ethanol and water. The highest titratable acidity was obtained with 50% ethanol of Cassia tora L.. The free sugar contents of Cassia tora L. extracted with water showed the highest value. Cassia tora L. extracts with water included higher contents of free sugar compared with those of the other solvent extracts, 50% ethanol and 75% ethanol extracts. The total polyphenol compound content of Cassia tora L. extracted with 50% ethanol showed the highest value. Cassia tora L. extracts with 50% ethanol included higher contents of total polyphenol compound compared with those of the other solvent extracts, water and 75% ethanol extracts.
김현구,나경민,예수향,한호석 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.5
The present study was conducted to investigate extraction characteristics and antioxidative activity of Schiznadra chinensis extracts. Schiznadra chinensis was extracted by reflux extraction(RE) under different extraction conditions including solvent. The solid yield, turbidity, color value, titratable acidity, free sugar contents, electron donating ability(EDA) and superoxide dismutase(SOD)-like ability of Schiznadra chinensis extracts were determined. The highest solid yield value was obtained with water of 10 fold. No significant difference in turbidity and color value were found among the extracts prepared with various extraction solvents, 75% ethanol, 50% ethanol and water. The highest titratable acidity was obtained with water extracts of Schiznadra chinensis. The free sugar contents of Schiznadra chinensis extracted with water showed the highest value. Schiznadra chinensis extracts with water included higher contents of free sugar compared with those of the other solvent extracts, 50% ethanol and 75% ethanol extracts. The total polyphenol compound content of Schiznadra chinensis extracted with 50% ethanol showed the highest value. Schiznadra chinensis extracts with 50% ethanol included higher contents of total polyphenol compound compared with those of the other solvent extracts, water and 75% ethanol extracts. The electron donating ability of extracts were 60.87% in water, 57.24% in 50% ethanol, and 55.61% in 75% ethanol.
Long non-coding RNAs: key regulators of liver and kidney fibrogenesis
( Su-hyang Han ),( Je Yeong Ko ),( Eun Seo Kang ),( Jong Hoon Park ),( Kyung Hyun Yoo ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.7
Fibrosis is a pathological condition that is characterized by an abnormal buildup of extracellular matrix (ECM) components, such as collagen, in tissues. This condition affects various organs of the body, including the liver and kidney. Early diagnosis and treatment of fibrosis are crucial, as it is a progressive and irreversible process in both organs. While there are certain similarities in the fibrosis process between the liver and kidney, there are also significant differences that must be identified to determine molecular diagnostic markers and potential therapeutic targets. Long non-coding RNAs (lncRNAs), a class of RNA molecules that do not code for proteins, are increasingly recognized as playing significant roles in gene expression regulation. Emerging evidence suggests that specific lncRNAs are involved in fibrosis development and progression by modulating signaling pathways, such as the TGF-β/Smad pathway and the β-catenin pathway. Thus, identifying the precise lncRNAs involved in fibrosis could lead to novel therapeutic approaches for fibrotic diseases. In this review, we summarize lncRNAs related to fibrosis in the liver and kidney, and propose their potential as therapeutic targets based on their functions. [BMB Reports 2023; 56(7): 374-384]
원수희(Su-hee Won),김수겸(Su-kyum Kim),채종원(Jong-won Chae),한조영(Cho-young Han),전형열(Hyoung-yoll Jun),이준희(Jun-hui Lee),박수향(Su-hyang Park),이재원(Jae-won Lee) 한국추진공학회 2013 한국추진공학회 학술대회논문집 Vol.2013 No.5
1N급 단일추진제 하이드라진 추력기 개발모델에 대한 인수수준 랜덤 진동시험이 수행되었다. 랜덤 진동시험은 기존 항공우주연구원의 1lbf 추력기의 시험절차를 참고하여 진행되었다. 랜덤 진동시험 결과로부터 1N급 추력기 개발모델로 구성된 이중추력기모듈의 고유진동수는 기준치를 훨씬 상회하였으며, 구조적으로 강건하다는 것을 확인하였다. 또한 진동시험 동안 추력기 내부 촉매의 손상은 없었으며, 이로 인한 연료공급 유로의 막힘 현상도 발생하지 않았다. Acceptance level random vibration test for development model of 1N-class monopropellant thruster has been performed. The random vibration test was carried out based on the KARI test procedure for 1lbf thruster. From the test results of random vibration, the natural frequency of the dual thurst module composed of 1N-class development model thrusters was much higher than the standard and the structural robustness was verified. The catalyst damage during the vibration test was not observed and the plugging phenomenon was not occurred either.
Role of RNA Polymerase II Carboxy Terminal Domain Phosphorylation in DNA Damage Response
Su-Jin Jeong,Hye-Jin Kim,Yong-Jin Yang,설자환,Bo-Young Jung,Jeong-Whan Han,Hyang-Woo Lee,조은정 한국미생물학회 2005 The journal of microbiology Vol.43 No.6
The phosphorylation of C-terminal domain (CTD) of Rpb1p, the largest subunit of RNA polymerase II plays an important role in transcription and the coupling of various cellular events to transcription. In this study, its role in DNA damage response is closely examined in Saccharomyces cerevisiae, focusing specifically on several transcription factors that mediate or respond to the phosphorylation of the CTD. CTDK-1, the pol II CTD kinase, FCP1, the CTD phosphatase, ESS1, the CTD phosphorylation dependent cis-trans isomerase, and RSP5, the phosphorylation dependent pol II ubiquitinating enzyme, were chosen for the study. We determined that the CTD phosphorylation of CTD, which occurred predominantly at serine 2 within a heptapeptide repeat, was enhanced in response to a variety of sources of DNA damage. This modification was shown to be mediated by CTDK-1. Although mutations in ESS1 or FCP1 caused cells to become quite sensitive to DNA damage, the characteristic pattern of CTD phosphorylation remained unaltered, thereby implying that ESS1 and FCP1 play roles downstream of CTD phosphorylation in response to DNA damage. Our data suggest that the location or extent of CTD phosphorylation might be altered in response to DNA damage, and that the modified CTD, ESS1, and FCP1 all contribute to cellular survival in such conditions. The phosphorylation of C-terminal domain (CTD) of Rpb1p, the largest subunit of RNA polymerase II plays an important role in transcription and the coupling of various cellular events to transcription. In this study, its role in DNA damage response is closely examined in Saccharomyces cerevisiae, focusing specifically on several transcription factors that mediate or respond to the phosphorylation of the CTD. CTDK-1, the pol II CTD kinase, FCP1, the CTD phosphatase, ESS1, the CTD phosphorylation dependent cis-trans isomerase, and RSP5, the phosphorylation dependent pol II ubiquitinating enzyme, were chosen for the study. We determined that the CTD phosphorylation of CTD, which occurred predominantly at serine 2 within a heptapeptide repeat, was enhanced in response to a variety of sources of DNA damage. This modification was shown to be mediated by CTDK-1. Although mutations in ESS1 or FCP1 caused cells to become quite sensitive to DNA damage, the characteristic pattern of CTD phosphorylation remained unaltered, thereby implying that ESS1 and FCP1 play roles downstream of CTD phosphorylation in response to DNA damage. Our data suggest that the location or extent of CTD phosphorylation might be altered in response to DNA damage, and that the modified CTD, ESS1, and FCP1 all contribute to cellular survival in such conditions.
Han, Ye Ri,Shim, Su-Hyang,Kim, Dong-Su,Jun, Chul-Ho THE AMERICAN CHEMICAL SOCIETY 2017 ORGANIC LETTERS Vol.19 No.11
<P>A new cascade double N-annulation method has been developed for the synthesis of benzoquinolizinium salts. The process takes place between allylamines, internal alkynes, and HBF4 in the presence of Rh(III)/Cu(II) complexes and leads to formation of multisubstituted benzoquinolizinium salts. Importantly, the resulting benzoquinolizinium salts serve as fluorescent materials whose emission wavelengths can be tuned by selection of appropriate substituents.</P>
Micromelia, Arthrogryposis, and Congenital Polycystic Disease in Newborn Piglets
Hyang Jee,Byungchul Kang,Su-Chung Yeom,Bong Kyun Park,Ho Jae Han,Dae-Yong Kim 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.3
Defect of musculoskeletal system and congenital polycystic disease were diagnosed in two newborn piglets, respectively. Case 1 piglet was diagnosed as micromelia of the limbs and arthrogryposis of the hindlimbs. These are quite common in defect of musculoskeletal system and the causes such as viral infection and heredity should be primarily considered. Case 2, a ten-day-old piglet that was diagnosed as congenital polycystic disease, was dead without any clinical signs. At necropsy, numerous cysts filled with serous fluid were present in the liver and kidney. In addition, cleft palate was noted in hard palatine as well as soft palatine. Polycystic disease is generally inherited as an autosomal dominant trait.