http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Hee Joung Joung ),( Yong Ho Lee ),( In Su Lim ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1
Purpose: The Purpose of this study was to report changes in body composition, Insulin, Glucose, lipid profiles and IGF-1 in a Prader Willi syndrome (PWS) patient with type 2 diabetes during long-term exercise. In addition, this paper would like to propose the use of exercise as a basis treatment for PWS patients for not only relieving GH side effect but also improving obesity. Method: The subject was a 23-year-old man in a weight (107kg), height (151.1cm) and BMI (47.4kg/m²). He was diagnosed PWS and type 2 diabetes at age 12 years. He has taken medison and injection for type 2 diabetes. Exercise sessions were performed 5 times per week for 24 weeks. Intensity of exercise gradually increased, including the endurance and resistance exercise. Result: Body composition decreased in BMI to 44.4kg/m², weight to 101.3kg, fat mass to 51.1 % and lean mass to 29.6kg. Mean blood glucose concentration decreased from 123mg/dL to 109mg/dL, while insulin values increased from 2.3μU/mL to 9.9 μU/ml. At 15 and 20 week, he was prescribed to stop the insulin injection. Although lipid profiles increased, TG/HDL-C ratio decreased from 3 at risk level to 1.4 at normal level. Leptin level waxed and waned. IGF-1 levels increased from 90μg/L to 170μg/L. Conclusion: This case presents that long-term exercise could have beneficial effects on improvement of abnormal body composition, insulin sensitivity and IGF-1 in a PWS patient with type 2 diabetes. With these findings, although exercise in PWS patients cannot entirely substitute for a GH treatment, it could take the role of relieving side effects of GH treatment and improving obesity. We therefore conclude that long-term exercise in PWS patients with type 2 diabetes and GHD may not only improve risk factors related to obesity but also relieve GH side effects. Thus, we propose that exercise would be used as a basis treatment for PWS patients with or without GH treatment.. ……..
Volatile Flavor Compounds in the Leaves of Fifteen Taxa of Korean Native Chrysanthemum Species
Su Jeong Kim,Tae Joung Ha,Jongyun Kim,Jung Hwan Nam,Dong Lim Yoo,Jong Taek Suh,Ki Sun Kim 한국원예학회 2014 원예과학기술지 Vol.32 No.4
This study was conducted to compare the volatile flavor compounds found in the leaves of 15 taxa of Korean native Chrysanthemum species. The volatile flavor compounds from the taxa were collected using a simultaneous steam distillation and extraction technique and were analyzed using gas chromatography/mass selective detector (GC/MSD). A total of 45 volatile flavor compounds were identified with six functional groups: 14 alcohols, 4 ketones, 19 hydrocarbons, 5 esters, 2 acids, and 1 aldehyde. The main functional group in 15 taxa of Chrysanthemum species was alcohols, accounting for 28.7% of volatile flavor compounds, followed by ketones (21.2%) and hydrocarbons (13.2%). Camphor, which is known for its antimicrobial properties, was the most abundant volatile compound (30%) in C. zawadskii ssp. latilobum and var. leiophyllum. In particular, C. indicum subspecies and C. boreale contained -thujone, which has outstanding anti-bacterial, anti-cancer, anti-inflammatory, anti-ulcer, and anti-diabetic efficacies. C. indicum var. albescens could be used in perfumes, since it showed 21 times more camphene than C. indicum. In addition, C. indicum var. acuta contained a fairly high content of 1,8-cineole, which has an inhibitory effect on mutagenesis. C. lineare contained only pentadecanoic acid compounds, whereas other taxa hexadecanoic acids. Overall, the Korean native Chrysanthemum species had considerable variation in volatile flavor compounds in their leaves. This study provides a good indication of specific potential use for various applications.
Neuroprotective Effects of Berberine in Neurodegeneration Model Rats Induced by Ibotenic Acid
Lim, Jung-Su,Kim, Hyo-Sup,Choi, Yoon-Seok,Kwon, Hyock-Man,Shin, Ki-Soon,Joung, In-Sil,Shin, Mi-Jung,Kim, Yun-Hee The Korean Society for Integrative Biology 2008 Animal cells and systems Vol.12 No.4
Berberine, an isoquinoline alkaloid found in Coptidis Rhizoma(goldenthread) extract, has multiple pharmacological effects such as anti-inflammatory, antimicrobial and anti-ischemic effects. In the present study, we examined the effects of berberine on neuronal survival and differentiation in a hippocampal precursor cell line and in the memory deficient rat model. Berberine increased in a dose dependent manner the survival of hippocampal precursor cells as well as differentiated cells. In addition, berberine promoted neuronal differentiation of hippocampal precursor cells. In the memory deficient rat model induced by stereotaxic injection of ibotenic acid into entorhinal cortex(Ibo model), hippocampal cells were increased about 2.7 fold in the pyramidal layer of CA1 region and about 2 fold in the dentate gyrus by administration of berberine after 2 weeks of ibotenic acid injection. Furthermore, neuronal cells immunoreactive to calbindin were increased in the hippocampus and entorhinal cortex area by administration of berberine. Taken together, these results suggest that berberine has neuroprotective effect in the Ibo model rat brain by promoting the neuronal survival and differentiation.
Lim Byung-Hyuk,Im Jee-Aee,Jo Yoon-Kyung,Kim In-Sik,Lee Kyu-Jae,Yang Eun-Ju,Lim Su-Joung,Ryang Yong-Suk The Korean Society for Biomedical Laboratory Scien 2004 Journal of biomedical laboratory sciences Vol.10 No.4
Eosinophils play an essential role in allergy reaction after parasite infection. To examine the immune reaction induced by eosinophils, we investigated the allergy reaction in BALB/c mice infected with Echinostoma hortense's metacercariae, as well as the effect of ketotifen, an anti-allergy drug, on eosinophil immune reaction in the villi of host intestine. The worm recovery rate was higher in ketotifen-treated mice than in untreated mice and the worms in ketotifen-treated mice survived longer than those in untreated mice. The antibody titer in the serum of ketotifen-treated mice was very low. Especially, Echinostoma hortense infection strongly increased serum IgE level and eosinophil infiltration into the villi of the mouse intestine. Ketotifen treatment suppressed eosinophil infiltration into the infected areas and inhibited IL-4 production. The reduced IL-4 production may be related with the reduction of IgE, IgG1 and IgG2 production. In conclusion, ketotifen inhibited eosinophil infiltration functioning in the allergy reaction induced by parasite infection and the expression of immunoglobulins and cytokines.
PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain
Lim, Ilhan,Joung, Hye-Young,Yu, A Ram,Shim, Insop,Kim, Jin Su Hindawi Publishing Corporation 2016 BioMed research international Vol.2016 No.-
<P>A considerable number of patients with breast cancer complain of cognitive impairment after chemotherapy. In this study, we showed that donepezil enhanced memory function and increased brain glucose metabolism in a rat model of cognitive impairment after chemotherapy using behavioral analysis and positron emission tomography (PET). We found that chemotherapy affected spatial learning ability, reference memory, and working memory and that donepezil improved these cognitive impairments. According to PET analysis, chemotherapy reduced glucose metabolism in the medial prefrontal cortex and hippocampus, and donepezil increased glucose metabolism in the bilateral frontal lobe, parietal lobe, and hippocampus. Reduced glucose metabolism was more prominent after treatment with doxorubicin than cyclophosphamide. Our results demonstrated the neural mechanisms for cognitive impairment after chemotherapy and show that cognition was improved after donepezil intervention using both behavioral and imaging methods. Our results suggested that donepezil can be employed clinically for the treatment of cognitive deficits after chemotherapy.</P>