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04 포스터 발표 : 농식품 환경분야(PF) ; PF-01 : 마우스모델에서 PKC 독립적 오토파아지와 아팝토시스유도를 통한 대장암세포 손상 조절에 관여하는 푸마니신 B1의 역할
마헨드라 ( Mahendra Pal Singh ),소렌폴 ( Souren Paul ),강선철 ( Sun Chul Kang ) 한국환경농학회 2015 한국환경농학회 학술대회집 Vol.2015 No.-
Induction of pro-death mechanisms during oxidative stress can be divided into two categories, autophagy and apoptosis. FB1 induced toxicity in colon tissues include particular type of cell death via oxidative stress is not clear yet. For this purpose, we employed murine model and intraperitoneally injected with FB1 (2.5mg/kg body weight) to explore the cellular damage response in colon tissue. As a result of consecutive four days treatment of FB1 led to disorganized tissue architecture elucidated by hematoxyline and eosin staining, altered activity of basic metabolic enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in blood serum and plasma. Moreover, FB1 treatment activated autophagy and apoptosis related signaling mechanisms characterized by induced expression of associated markers such as PERK, IRE1α, BECN1 and LC3II. In addition, we observed reduced protein kinase c (PKC) activity. All these recorded parameters clearly depict oxidative stress mediated induction of autophagy and apoptosis which led to colon tissue damage in response to FB1 treatment in independent to PKC expression. Therefore, altogether these results indicate the role oxidative stress induced autophagy and apoptosis mechanism in FB1 mediated colon tissue damage.
농식품 환경 분야(PF) : 말굽버섯에서 분리된 다당류의 항암활성
리카자카 ( Rekha Jakhar ),소렌폴 ( Souren Paul ),강선철 ( Sun Chul Kang ) 한국환경농학회 2014 한국환경농학회 학술대회집 Vol.2014 No.-
Mushrooms are known to complement chemotherapy and radiation therapy by countering the side-effects of cancer. Recently, a great deal of interest has been developed to isolate novel bioactive compounds from mushrooms because of their numerous health beneficial effects. Chemically water-extractable polysaccharide (MFKF-AP1β) was isolated from fruiting bodies of mushroom Fomes fomentarius. In this research, we investigated the anticancer effects of MFKF-AP1β on human lung carcinoma A549 cell. Results showed that MFKF-AP1β distinctly inhibited A549 cells growth in a dose-dependent manner and induced cell apoptosis evidenced by apoptosis assay. Besides that, MFKF-AP1β induced the LDH release and causes morphological alterations. Furthermore, the MFKF-AP1β (25.100 μg/ml) resulted in a significant single strand DNA breakage, on A549 cells as shown by comet assay. Taken together, our results demonstrate that MFKF-AP1β possesses strong antitumor activities through the induction of apoptosis. All these results suggested that MFKF-AP1β has evident anticancer activity through apoptotic induction.