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Cell Therapy Products in Alzheimer Disease
( Hyeon Jin Song ),( Tae-hee Kim ),( Hae-hyeog Lee ),( Jun-mo Kim ),( Yoo Jin Park ),( Arum Lee ),( Soo Ah Kim ),( Hye Ji Choi ) 대한폐경학회 2017 대한폐경학회지 Vol.23 No.1
We are rapidly becoming an aging society, with the ongoing increase in challenges of the elderly. The age-related cognitive decline in accordance with aging society is of major importance in public health. Recent studies have proved the impacts of sex-steroid hormone on the brain; compliant with aging, menopause and decrease in estrogen have an effect on the occurrence and prevention of Alzheimer`s disease. A new hypothesis states that Alzheimer`s disease is a postmenopausal dementia, and is a negative form of estrogen deficiency. In this review article, we reckoned the cause of postmenopausal Alzheimer`s disease. We further investigated new cell therapies for postmenopausal Alzheimer`s disease, which are under development in some pharmaceutical companies. One remedy is cell therapy that inhibits the amyloid beta formation, and the other is the umbilical cord blood derived mesenchymal stem cell therapy. (J Menopausal Med 2017;23:1-4)
Mo, Min Ju,Hwang, Doo Ree,Lee, Ju Hyeon,Kim, Dong Hoo,Hwang, Seon Hye,Sohn, Soo Ah,Hwang, Ji Hoo Korean AcupunctureMoxibustion Medicine Society 2017 대한침구의학회지 Vol.24 No.5
Objectives : Cervical herniated intervertebral disc (HIVD) are common diseases. They can be managed with acupuncture, but the evidence for effectiveness is uncertain. This review analyzed the acupuncture studies of domestic neck pain and cervical HIVD; the purpose of this study was to provide basic data useful for future research. Methods : We investigated acupuncture treatments for neck pain and cervical HIVD by searching 5 Korean Internet databases. The keywords used were "neck pain", "HIVD-cervical spine", and "nuchal pain". A total of 53 research papers (17 case reports, 16 clinical data analyses, 11 randomized controlled trials, and 9 non-randomized controlled trials) were found and analyzed according to the publication year, type of study, treatment, use of filiform needles, and type of pharmacopuncture used acupoint. The effectiveness of acupuncture treatment was determined. Results : 1. Filiform needles have been primarily used in domestic research and were used in at least half of published pharmacopuncture studies. 2. In 51 papers using filiform needles, many studies used only local acupoints; few studies used only distant acupoints. 3. All studies using pharmacopuncture were performed using local acupoints. In particular, the studies based on A-shi point, trigger point, and radiologic lesion sites were useful for multiple purposes. Conclusion : In this study, we analyzed the acupuncture contents of the domestic neck pain and HIVD-cervical spine clinical studies. This study considers the assessment of the quality and efficacy of each study, which is likely to require research that reflects the future.
가토에서 헤파린은 허혈 재관류로 인한 신장의 조직 손상을 완화하는가?
정현주,신증수,김갑수,방은치,안진모,김정열 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.1
Background : Increasing degrees of medullary hyperemia induced by ischemia reperfusion injury were associated with renal dysfunction. A possible mechanism may be that ischemia causes alterations in the structure and function of vascular membranes which leads to an aggregation of red blood cells in the medullary vessel. It has been shown that heparin prevents postischemic endothelial cell dysfunction. Aim of this study was to evaluate heparin effects on renal hyperemia induced by ischemia reperfusion injury. Method : In this study, fifteen rabbits were randomized to either heparin treatment group(500 IU/kg IV bolus 10 minutes before renal artery occlusion, n=8) or control group(n=7). One side kidney underwent 60 minutes ischemia only by clamping renal pedicle and after that kidney tissue sample was obtained for histologic evaluation. The other side of kidney were permitted 60 minutes ischemia following 60 minutes reperfusion and after that kidney tissue sample was obtained for histologic evaluation. Results : There was significant difference in the degree of congestion(2.6±0.2 vs 1.1±0.3, P<0.05) between outer medulla of control and heparin treatment group. Conclusion : Heparin significantly attenuated outer medullary congestion induced ischemic injury. (Korean J Anesthesiol 1998; 35: 23∼28)
Lee, Soo Jung,Kang, Byung Woog,Moon, Joon Ho,Chae, Yee Soo,Kim, Jong Gwang,Jung, Joo Seop,Cho, Goon-Jae,Jo, Deog-Yeon,Kim, Yeo Kyeoung,Kim, Hyeoung Joon,Ryoo, Hun-Mo,Eom, Hyeon Seok,Le, Sang Min,Joo, S. Karger AG 2012 Acta haematologica Vol.127 No.2
<P>Abstract</P><P>This study compared the results of allogeneic peripheral blood stem cell transplantation (PBSCT) from unrelated and related donors in 142 consecutive patients with acute myeloid leukemia (AML). The cumulative incidence of acute graft-versus-host disease (GVHD) was 37.6% in the related PBSCT group and 53.7% in the unrelated PBSCT group. The cumulative incidence of extensive chronic GVHD was also higher in the unrelated PBSCT group (19.5%) than in the related PBSCT group (8.9%). The overall survival rate at 4 years was 62.4 ± 5.4 and 53.8 ± 1.2% (p = 0.535) in the related and unrelated PBSCT group, respectively. In a multivariate analysis, unrelated PBSCT was identified as a risk factor for the development of extensive chronic GVHD (hazard ratio = 3.019, p = 0.027). Unfavorable cytogenetics and the disease status at the time of transplantation were found to be related to overall survival. In the case of high-risk AML, the survival rate and relapse incidence were significantly better in the matched unrelated PBSCT group (p = 0.047 and 0.039, respectively). In conclusion, the allogeneic PBSCT outcomes for AML were comparable in the matched related and matched unrelated groups. Nonetheless, for high-risk AML patients, matched unrelated PBSCT was found to be preferable to matched related PBSCT.</P><P>Copyright © 2011 S. Karger AG, Basel</P>
Jun, Soo Youn,Jang, In Jin,Yoon, Seonghae,Jang, Kyungho,Yu, Kyung-Sang,Cho, Joo Youn,Seong, Moon-Woo,Jung, Gi Mo,Yoon, Seong Jun,Kang, Sang Hyeon American Society for Microbiology 2017 Antimicrobial Agents and Chemotherapy Vol.61 No.6
<P><B>ABSTRACT</B></P><P>This study was a phase 1, single-center, randomized, double-blind, placebo-controlled, single-dosing, and dose-escalating study of intravenous SAL200. It is a new candidate drug for the treatment of antibiotic-resistant staphylococcal infections based on a recombinant form of the phage endolysin SAL-1. The study evaluated the pharmacokinetics, pharmacodynamics, and tolerance among healthy male volunteers after the intravenous infusion of single ascending doses of SAL200 (0.1, 0.3, 1, 3, and 10 mg/kg of body weight). SAL200 was well tolerated, and no serious adverse events (AEs) were observed in this clinical study. Most AEs were mild, self-limiting, and transient. The AEs reported in more than three participants were fatigue, rigors, headache, and myalgia. No clinically significant values with respect to the findings of clinical chemistry, hematology, and coagulation analyses, urinalysis, vital signs, and physical examinations were observed, and no notable trends in our electrocardiogram (ECG) results for any tested dose were noticed. A greater-than-dose-proportional increase with regard to systemic exposure and the maximum serum concentration was observed when the SAL200 dose was increased from 0.1 mg/kg to 10 mg/kg. This investigation constitutes the first-in-human phase 1 study of an intravenously administered, phage endolysin-based drug. (This study has been registered at ClinicalTrials.gov under identifier NCT01855048 and at the Clinical Research Information Service [https://cris.nih.go.kr/cris/] under identifier KCT0000968.).</P>