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RISS 인기검색어
- 검색키워드
- 저자 : Somanathan, S.S. (검색결과 4 건)
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Kumar, K. Asok,Umamaheswari, M.,Sivashanmugam, A.T.,Subhadradevi, V.,Somanathan, S.S.,Ravi, T.K. Kyung Hee Oriental Medicine Research Center 2009 Oriental pharmacy and experimental medicine Vol.9 No.4
Oxidative stress plays an important role in the pathogenesis of various diabetic complications and small intestine is vulnerable to damage resulting in morphological and functional changes. In this study, the effects of Asystasia gangetica leaf extract (AGLE) on oxidative stress status in small intestine of diabetic rats were examined. The leaves of Asystasia gangetica was extracted with 70% ethanol. Oral administration of AGLE once daily (100 mg/kg and 200 mg/kg b.w.) for 28 days to diabetic rats significantly (P < 0.05) increased antioxidant levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione, GSSH, carbohydrate metabolizing enzyme, glucose-6-phosphate dehydrogenase. The increased levels of protein carbonyl content, lipid peroxidation and xanthine oxidase/xanthine dehydrogenase in diabetic rats were reverted back to near normal levels on treatment with AGLE. Both doses of AGLE offered significant activity (P < 0.01) against oxidative damage and were comparable with standard, glibenclamide. The results revealed the occurrence of oxidative stress in small intestine during diabetes and suggest the potential of AGLE as an antioxidant in protecting the tissue defense system against oxidative damage in streptozotocin-induced diabetes.
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K Asok Kumar,M Umamaheswari,AT Sivashanmugam,V Subhadradevi,SS Somanathan,TK Ravi 경희대학교 융합한의과학연구소 2009 Oriental Pharmacy and Experimental Medicine Vol.9 No.4
Oxidative stress plays an important role in the pathogenesis of various diabetic complications and small intestine is vulnerable to damage resulting in morphological and functional changes. In this study, the effects of Asystasia gangetica leaf extract (AGLE) on oxidative stress status in small intestine of diabetic rats were examined. The leaves of Asystasia gangetica was extracted with 70% ethanol. Oral administration of AGLE once daily (100 mg/kg and 200 mg/kg b.w.) for 28 days to diabetic rats significantly (P < 0.05) increased antioxidant levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione, GSSH, carbohydrate metabolizing enzyme, glucose-6- phosphate dehydrogenase. The increased levels of protein carbonyl content, lipid peroxidation and xanthine oxidase/xanthine dehydrogenase in diabetic rats were reverted back to near normal levels on treatment with AGLE. Both doses of AGLE offered significant activity (P < 0.01) against oxidative damage and were comparable with standard, glibenclamide. The results revealed the occurrence of oxidative stress in small intestine during diabetes and suggest the potential of AGLE as an antioxidant in protecting the tissue defense system against oxidative damage in streptozotocin-induced diabetes. Oxidative stress plays an important role in the pathogenesis of various diabetic complications and small intestine is vulnerable to damage resulting in morphological and functional changes. In this study, the effects of Asystasia gangetica leaf extract (AGLE) on oxidative stress status in small intestine of diabetic rats were examined. The leaves of Asystasia gangetica was extracted with 70% ethanol. Oral administration of AGLE once daily (100 mg/kg and 200 mg/kg b.w.) for 28 days to diabetic rats significantly (P < 0.05) increased antioxidant levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione, GSSH, carbohydrate metabolizing enzyme, glucose-6- phosphate dehydrogenase. The increased levels of protein carbonyl content, lipid peroxidation and xanthine oxidase/xanthine dehydrogenase in diabetic rats were reverted back to near normal levels on treatment with AGLE. Both doses of AGLE offered significant activity (P < 0.01) against oxidative damage and were comparable with standard, glibenclamide. The results revealed the occurrence of oxidative stress in small intestine during diabetes and suggest the potential of AGLE as an antioxidant in protecting the tissue defense system against oxidative damage in streptozotocin-induced diabetes.
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Determinants of Participation in a Breast Cancer Screening Trial in Trivandrum District, India
Frie, Kirstin Grosse,Ramadas, Kunnambath,Anju, Gopan,Mathew, Beela Sara,Muwonge, Richard,Sauvaget, Catherine,Thara, Somanathan,Sankaranarayanan, Rengaswamy Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background: Conspicuous differences in participation rates for breast self-examination (BSE), clinical breast examination (CBE), and referral for further investigations have been observed indicating involvement of a number of different factors. This study analysed determinants for participation in different levels of the breast cancer screening process in Indian females. Materials and Methods: An intervention group of 52,011 women was interviewed in a breast cancer screening trial in Trivandrum district, India. In order to assess demographic, socio-economic, reproductive, and cancer-related determinants of participation in BSE, CBE, and referral, uni- and multi-variate logistic regression was employed. Results: Of the interviewed women, 23.2% reported practicing BSE, 96.8% had attended CBE, and 49.1% of 2,880 screen-positives attended referral. Results showed an influence of various determinants on participation; women who were currently not married or who had no family history of cancer were significantly less likely to attend the screening process at any level. Conclusions: Increasing awareness about breast cancer, early detection methods, and the advantages of early diagnoses among women, and their families, as well as health care workers offering social support, could help to increase participation over the entire screening process in India.
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라지아추단,Thomas Nesakumar Jebakumar Immanuel Edison,Mani Shanmugam,Suguna Perumal,Rajangam Vinodh,Thirunavukkarasu Somanathan,이용록 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.98 No.-
Here, a unique heteroatom-doped spongy carbonaceous material from dwarf banana peel has beensynthesized successfully using the one-step hydrothermal method. The discarded banana peel wasreused as a carbon source for the formation of heteroatom-doped porous carbon. This biowaste-derivedheteroatom-doped porous carbonaceous material (BH-PCM) has plenty of interconnected pores with anacceptable surface area of 213 m2 g 1. Thoroughly characterized BH-PCM has been used as electrodematerial for supercapacitor using a three-electrode system with an aqueous 1 M H2SO4 solution. The assynthesizedBH-PCM holds an excellent specific capacitance of 137 F g 1 at 0.5 A g 1 and an impressiverate performance with a capacitance enduring 51 F g 1 at 5.0 A g 1. After 10,000 galvanostatic charge–discharge cycles, an initial capacitance of 94% was maintained. To show the practical applicability of theBH-PCM, the symmetrical two-electrode cell was fabricated and delivered the gravimetric specificcapacitances of 87 F g 1 at 1 A g 1. The excellent electrochemical performance of BH-PCM towardssupercapacitor was due to their high surface area, reasonable heteroatom doping rate, and a suitabledegree of graphitization. This study offers a green approach for the development of environmental-friendly potential carbon-based electrode, by converting biowaste to clean/green energy.
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