심박동변이 검사를 통한 수은의 심장 자율신경기능 영향

임신예,최민철,조기옥,백도명 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.4

목적 최근 수은이 심혈관계통에 미치는 영향에 대한 연구들이 발표되고 있다 본 연구는 지역사회 주민들을 대상으로 모발에서 수은 분석 및 심박동변이 검사를 실시하여 이들 간의 관계를 분석함으로써 수은의 심장 자율신경기능에 미지는 영향을 알아보고자 하였다 방법 모발 채취는 미용사가 후두부에서 모근에서 최대한 가깝도록 자른 다음 모근부위를 표시하여 보관하였다 모발 수은 측정은 열분해 촉매변환 아말감화와 원자흡수분광법의 네단계를 거쳐 분석하는 Direct Mercury Analyzer (DMA-80)를 이용하여 분석하였다 심혈관계질환의 알려진 위험요인을 조사하기 위해 의사가 면담을 통하여 고혈압 당뇨병 등의 과거력을 확인하였고 혈압을 측정하였으며 신체계측으로 비만여부를 확인하였고 총콜레스테롤 중성지방 고밀도지단백 콜레스테롤 등을 분석하기 위때 정맥혈을 채취하였다 심박동변이는 Medi-core사의 SA-3000P를 이용하여 조용한 방에서 가만히 앉아 있는 상태에서 5분 동안 시간 범위와 주파수 범위를 측정하였다 심혈관질환 위험요인들을 보정한 상태에서 모발 수은과 심박동변이검사와의 관계를 분석하였다 통계분석은 SAS 9 1 3을 이용하였다 결과 건강검진에 참여하여 의사검진 혈액검사 모발 수은 검사 및 심박동변이 검사를 수행한 671명(남자 307명 여자 364명)을 대상으로 결과를 분석하였다 평균 연령은 36세(범위 6~83세)였다 조사대상자들에서의 모발수은의 기하평균은 0.90 ppm(범위 0.12-13.36 ppm) 이었다 남자에서 연령이 증가할수록 현재 흡연군 잦은 음주군 농업 임업 및 어업숙련 종사자군과 임원 및 관리자군에서 모발 수은 농도가 높았다 모발 수은 농도와 연령 수축기 및 이완기 혈압 총콜레스테롤 중성지방 저밀도지단백 콜레스테롤 체질량지수와 모발 수은은 유의한 양의 상관관계를 보였고 심박동수와 고밀도지단백 콜레스테롤 SDNN TP LF HF 값과는 유의한 음의 상관관계를 보였다 모발 수은 농도가 높은 군에서 낮은 군에 비해 심박동수 및 SDNN LF HF 값이 유의하게 감소하고 수축기 및 이완기 혈압은 유의하게 증가하는 경향을 보였다 다중선형회귀분석을 이용하여 성별 연령 등 심혈관질환 위험요인들을 보정한 후에도 모발 수은 농도가 로그 1 ppm 증가함에 따라 심박동수는 2.6회/분 감소하고 Ln (HF)값은 0.131 msec² HF norm은 2.550 감소하였다 결론 본 연구를 통하여 수은 노출이 심장의 부교감신경계 기능에 미치는 영향을 확인하였다 추가적인 연구를 통하여 수은 노출과 심혈관계 질환의 장기영향 조사가 필요하다 Objectives The effect of mercury on the cardiovascular system has recently been reported on but the mechanisms as well as its nature of this effect still need to be confirmed In this study the mercury in the hair of a community population was analyzed in relation to the cardiac autonomic activity. Methods A hair sample was obtained from the occiput area and the mercury in the hair was analyzed by using a Direct Mercury Analyzer. We measured the cardiovascular risk factors including total Cholesterol, triglyceride blood pressure and the body mass index (BMI) Heart rate variability was assessed for 5 minutes in the time and frequency domain by using SA-3000P from the Medi-core company The association between the mercury in the hair and heart rate variability was assessed after controlling for the other cardiovascular risk factors Results The mean age of the 671 total subjects was 36 years The geometric mean of the hair mercury was 0.90 ppm The hair mercury level was elevated in males adults smokers and drinkers Hair mercury and age the systolic and diastolic blood pressure total cholesterol triglyceride. LDL cholesterol and BMI were all positively correlated However hair mercury and heart rate, HDL cholesterol standard deviation of the NN intervals (SDNN) total power (TP) low-frequency (LF) high- frequency (HF) were negatively correlated In the higher mercury group heart rate SDNN LF and HF indices were Significantly lower compared with those of the lower mercury group Heart rate was decreased 2.6 beats/min Ln (HF) was decreased 0.131 msec² and HF norm was decreased 2.550 with a 1 ppm increase of Ln (Hg), according to multiple linear regression analysis after controlling for age gender and other cardiovascular risk factors Conclusion This cross-sectional study showed that mercury may affect the cardiac autonomic activity through parasympathetic dysfunction.

The relationship between spontaneous abortion and female workers in the semiconductor industry

Heechan Kim,Ho-Jang Kwon,Jeongbae Rhie,Sinye Lim,Yun-Dan Kang,Sang-Yong Eom,Hyungryul Lim,Jun-Pyo Myong,Sangchul Roh 대한직업환경의학회 2017 대한직업환경의학회지 Vol.29 No.-

Background: This study investigated the relationship between job type and the risk for spontaneous abortion to assess the reproductive toxicity of female workers in the semiconductor industry. Methods: A questionnaire survey was administered to current female workers of two semiconductor manufacturing plants in Korea. We included female workers who became pregnant at least 6 months after the start of their employment with the company. The pregnancy outcomes of 2,242 female workers who experienced 4,037 pregnancies were investigated. Personnel records were used to assign the subjects to one of three groups: fabrication process workers, packaging process workers, and clerical workers. To adjust for within-person correlations between pregnancies, a generalized estimating equation was used. The logistic regression analysis was limited to the first pregnancy after joining the company to satisfy the assumption of independence among pregnancies. Moreover, we stratified the analysis by time period (pregnancy in the years prior to 2008 vs. after 2009) to reflect differences in occupational exposure based on semiconductor production periods. Results: The risk for spontaneous abortion in female semiconductor workers was not significantly higher for fabrication and packaging process workers than for clerical workers. However, when we stratified by time period, the odds ratio for spontaneous abortion was significantly higher for packaging process workers who became pregnant prior to 2008 when compared with clerical workers (odds ratio: 2.21; 95% confidence interval: 1.01–4.81). Conclusions: When examining the pregnancies of female semiconductor workers that occurred prior to 2008, packaging process workers showed a significantly higher risk for spontaneous abortions than did clerical workers. The two semiconductor production periods in our study (prior to 2008 vs. after 2009) had different automated processes, chemical exposure levels, and working environments. Thus, the conditions prior to 2008 may have increased the risk for spontaneous abortions in packaging process workers in the semiconductor industry.

Emotional labor and dysmenorrhea in women working in sales and call centers

In-Jung Cho,Hyunjoo Kim,Sinye Lim,Sung-Soo Oh,Hee-Tae Kang 대한직업환경의학회 2014 대한직업환경의학회지 Vol.26 No.-

Objectives: This study was conducted to investigate the association between emotional labor and dysmenorrhea among women working in sales and call centers in Seoul, South Korea. Methods: Working women in sales jobs and call centers in Seoul were interviewed face-to-face by well-trained interviewers. In total, 975 participants were analyzed in the final model. Emotional labor was measured using a constructed questionnaire with two components: an emotive effort component with three questions and an emotive dissonance component with five questions. To examine the association between emotional labor and dysmenorrhea, chi-squared tests and logistic regression were applied. Results: The prevalence of dysmenorrhea among sales workers and call center workers were 43.0% and 61.1%, respectively. The adjusted odds ratios (OR) of emotive effort and emotive dissonance for dysmenorrhea in call center workers were 1.88 (95% confidence interval [CI], 1.07?3.28) and 1.72 (95% CI, 1.13?2.63), respectively. The adjusted OR of emotive effort and emotive dissonance for dysmenorrhea in sales workers were 1.71 (95% CI, 0.92?3.16) and 1.15 (95% CI, 0.67?1.98), respectively. Conclusions: Emotional labor was found to be associated with dysmenorrhea in call center workers. Further studies to investigate other factors, such as management strategies and the relationship between emotional labor and dysmenorrhea, are needed to support interventions to prevent dysmenorrhea that will further promote the quality of health and life of working women.

The Unequal Burden of Self-Reported Musculoskeletal Pains Among South Korean and European Employees Based on Age, Gender, and Employment Status

Bahk, Jinwook,Khang, Young-Ho,Lim, Sinye Occupational Safety and Health Research Institute 2021 Safety and health at work Vol.12 No.1

Background: The objective of this study was to elucidate the relationships musculoskeletal pains with combined vulnerability in terms of age, gender, and employment status Methods: The fifth European Working Conditions Survey (EWCS) in 2010 (43,816 participants aged 15 years and over) analyzed for European employees and the third Korean Working Conditions Survey (KWCS) in 2011 (50,032 participants aged 15 years and older) analyzed for Korean employees. In this study, three well known vulnerable factors to musculoskeletal pains (older age, female gender, and precarious employment status) were combined and defined as combined vulnerability. Associations of musculoskeletal pains with combined vulnerability were assessed with prevalence ratios (PRs) and 95% confidence intervals (CIs) estimated by Poisson regression models with robust estimates of variance. Results: The prevalences of musculoskeletal pains were lower but the absolute and relative differences between combined vulnerabilities were higher among Korean employees compared with the European employees. Furthermore, the increased risk of having musculoskeletal pains according to combined vulnerability was modestly explained by socioeconomic factors and exposure to ergonomic risk factors, especially in Republic of Korea. Conclusions: The results of this study showed that the labor market may be more unfavorable for female and elderly workers in Republic of Korea. Any prevention strategies to ward off musculoskeletal pains, therefore, should be found and implemented to mitigate or buffer against the most vulnerable work population, older, female, and precarious employment status, in Republic of Korea.

The relationship between night work and involuntary weight change

Jongho Kwon,Jung-Woo Park,Jin-Soo Park,Seyoung Kim,Hyunrim Choi,Sinye Lim 대한직업환경의학회 2016 대한직업환경의학회지 Vol.28 No.-

Background: Previous studies on the association between shift or night work and weight change have been focused on finding the risk of weight gain caused by shift or night work. In this study, we aimed to reveal the risk of weight gain and weight loss associated with night work by using a nationwide representative data. Methods: This study was performed on 1605 full-time wage workers between the age of 20 and 69 based on the fifth Korea National Health and Nutrition Examination Survey (KNHANES 2010–2012). The association between night work and involuntary weight change in the previous year was divided into the categories of weight gain and weight loss and studied with modifications in socio-demographic variables, health behavior-related variables, and occupational characteristic variables. Results: The participants working in night work accounted for 10.6 % of total study participants (male; 11.9 %, female 7.4 %). Workers who worked more than 48 hours per week on average accounted for 41.6 % of the total study participants (male; 46.3 %, female 29.1 %). Odds ratio (OR) of weight loss associated with night work in male workers was 0.34 (95 % confidence interval (CI) 0.16–0.76) after controlling for several related factors. OR of weight loss associated with night work in female workers with long working hours was 1.95 (95 % CI 0.47–80.86) and that of weight gain was 2.83 (95 % CI 0.12–69.83) after adjusting associated factors. Conclusions: In this cross-sectional study with national representative sample, night work may lower the risk of weight loss in male workers and induce weight change (weight loss or weight gain) in female workers with long working hours. Therefore, future studies with cohort study design for night workers are needed to reveal the mechanisms and health effects of weight change associated with night work and establish proper management solutions with health and labor policies for Korean night workers.

탄소 섬유에 노출된 포장 작업자들의 피부질환 집단 발생 사례

이혜은(Hye Eun Lee),변참범(Chang Bum Byun),임신예(Sinye Lim),전승호(Seung Ho Jeon),오상용(Sang-Yong Oh),김형렬(Hyoung-Ryoul Kim),최순(Soon Choi),백도명(Domyung Paek),박미진(Mijin Park) 대한직업환경의학회 2006 대한직업환경의학회지 Vol.18 No.3

The association between long working hours and hearing impairment in noise unexposed workers

Jung-Woo Park,Jin-Soo Park,Seyoung Kim,Minkyu Park,Hyunrim Choi,Sinye Lim 대한직업환경의학회 2016 대한직업환경의학회지 Vol.28 No.-

Background: This study is aimed at finding out the relationship between long working hours, one of major job stress elements, and hearing impairment in unexposed workers to occupational and environmental noise. Methods: This study was performed on 1628 regular, full-time wage workers between the age of 25-64 who indicated in the survey of having no experience of exposure to noise, normal otoscopic findings, and not suffering from diabetes based on the data from the fifth Korea National Health and Nutrition Examination Survey (KNHANES 2010–2012). The average working hours per week was categorized into 40 h and lower group, more than 40 to 48 h group, more than 48 to 60 h group, and more than 60 h group. The groups were defined as suffering from low or high frequencies hearing impairment if the average hearing threshold for 0.5, 1, 2 kHz or 3, 4, 6 kHz in both ears exceeds 25 dB based on the pure tone audiometry. The association between average weekly working hours and hearing impairment was analyzed using logistic regression after gender stratification. Results: The prevalences of low and high frequencies hearing impairment in male workers were 4.3 and 28.6 %, respectively, which were much higher than female’s prevalence of 2.7 and 11.1 %. For male workers, no significant association was found between average weekly working hours and low and high frequencies hearing impairment. For female workers, odds ratios (OR) of low and high frequencies hearing impairment were 4.22 (95 % confidence interval (CI) 1.09–16.27) and 4.49 (95 % CI 1.73–11.67), respectively, after controlling for several related factors, such as, age, Body Mass Index (BMI), socio-economic status, health-related behavioral, and occupational characteristics variables, in the final model in the group working more than 60 h compared to the group working 40 h and lower. In addition, a dose-response relationship was observed that ORs of low and high frequencies hearing impairment were increased according to increasing average weekly working hours. Conclusions: The association between long working hours and hearing impairment in both low and high frequencies was significant in Korean female workers with a dose-response relationship. Therefore, the law to change the culture of long working hours should be enacted in order to protect the workers’ health and improve the quality of life in Korean workers.

내분비계 환경호르몬 노출과 사춘기 발달과의 연관성

범은애(Eunae Burm),하미나(Mina Ha),손미아(Mia Son),임신예(Sinye Lim),김유미(Yu-Mi Kim),홍영습(Young-Seoub Hong),박인호(Inho Park),정해관(Hae-Kwan Cheong),강희태(Hee-Tae Kang),사공준(Joon Sakong),오경재(Gyung-Jae Oh),김수영(Soo-Young Kim 환경독성보건학회 2014 한국독성학회 심포지움 및 학술발표회 Vol.2014 No.5

Relationship between personal care products usage and triclosan exposure

Minkyu Park,Seyoung Kim,Yeji Kim,Do Jin Nam,Jae-Hong Ryoo,Sinye Lim 대한직업환경의학회 2019 대한직업환경의학회지 Vol.31 No.-

Background: We aimed to find the exposure level of triclosan (TCS), a known endocrine disruptor, related to the use of personal care products using a nationally representative data of the general population in Korea. Methods: This study included data of 6288 adults aged 19 years and older (2692 men, 3596 women), based on the Second Korean National Environmental Health Survey (KoNEHS 2012–2014). The data were divided according to gender. The frequency and proportion of each variable were determined by dividing participants into two groups based on the top 75th percentile concentration of urinary TCS (male: 1.096 μg/g creatinine, female: 1.329 μg/g creatinine). Odds ratios (ORs) were calculated using logistic regression analysis for the high TCS exposure and low TCS exposure groups. Results: Overall, the proportion of participants using personal care products was higher in women than in men. There was a significantly higher proportion of participants in the high TCS exposure group with younger age, higher education and income levels and with more frequent use of fragrance products, hair care products, body cleansers, cosmetics, and antimicrobial agents. In both men and women, ORs tended to increase with increased frequency of use of hair care products, body cleansers, and cosmetics before and after adjustment. Conclusions: Our findings demonstrate that as the frequency of use of personal care products increases, urine TCS concentration increases. Because TCS is a well-known endocrine disruptor, further studies are needed and explore other health effects with exposure to TCS in general population in Korea.

Female non-smokers’ environmental tobacco smoking exposure by public transportation mode

Seyoung Kim,Jin-Soo Park,Minkyu Park,Yeji Kim,Sinye Lim,Hye-Eun Lee 대한직업환경의학회 2018 대한직업환경의학회지 Vol.30 No.-

Background: This study aimed to analyze environmental tobacco smoking exposure in female nonsmokers by public transportation mode using representative data of Koreans. Methods: Data from the Second Korean National Environmental Health Survey (2012-2014) were analyzed. Urine cotinine was analyzed by public transport behavior, secondhand smoke exposure, socioeconomic factors, and health-related factors. Participants were 1322 adult females; those with the top 75% urine cotinine concentrations were assigned to the high exposure group. A logistic regression analysis was performed considering appropriate weights and stratification according to the sample design of the Second Korean National Environmental Health Survey. Results: The geometric mean of urine cotinine concentrations differed according to public transportation modes: subway (1.66 μg/g creatinine) bus (1.77 μg/g creatinine), and taxi (1.94 μg/g creatinine). The odds ratio [OR] was calculated for the high exposure group. The OR of the taxi (2.39; 95% confidence interval, 1.00-5.69) was statistically significantly higher than the subway value (reference), and marginally significant after adjusted with life style, sociodemographic factors and involuntary smoking frequency (2.42, 95% confidence interval, 0.97-6.04). Conclusions: The odds ratio of passengers who mainly used taxis was marginally significantly higher than those of passengers who used subways and buses after adjusted with life style and sociodemographic factors. Implementation of supplementary measures and further studies on exposure to environmental tobacco smoking in taxis are warranted.