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[타이어운동특성부문] 내압 및 수직하중을 받는 레디얼 타이어 카카스의 변형율에 관한 연구
박인정(Injeong Park),유현승(Hyunseung Yoo),성경진(Kyoungjin Seong),김두만(Dooman Kim),구본희(Bonhee Ku),심현우(Hyunwoo Shim) 한국자동차공학회 2001 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2001 No.11_2
In this paper, carcass strain on the sidewall of radial tire were measured by using the strain gage and compared with the results of finite element analysis. Nonlinear behavior of tire sidewall must be considered for the analysis of tire strain with inflation pressure. On calculating the inflation strain of carcass, material nonlinearity is essential.
Jung Kyeongmin,Yoon Joohyun,Ahn Yeeun,Kim Soyeon,Shim Injeong,Ko Hyunwoong,Jung Sang-Hyuk,Kim Jaeyoung,Kim Hyejin,Lee Dong June,Cha Soojin,Lee Hyewon,Kim Beomsu,Cho Min Young,Cho Hyunbin,Kim Dan Say,K 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Irritability is a heritable core mental trait associated with several psychiatric illnesses. However, the genomic basis of irritability is unclear. Therefore, this study aimed to 1) identify the genetic variants associated with irritability and investigate the associated biological pathways, genes, and tissues as well as single-nucleotide polymorphism (SNP)-based heritability; 2) explore the relationships between irritability and various traits, including psychiatric disorders; and 3) identify additional and shared genetic variants for irritability and psychiatric disorders. We conducted a genome-wide association study (GWAS) using 379,506 European samples (105,975 cases and 273,531 controls) from the UK Biobank. We utilized various post-GWAS analyses, including linkage disequilibrium score regression, the bivariate causal mixture model (MiXeR), and conditional and conjunctional false discovery rate approaches. This GWAS identified 15 independent loci associated with irritability; the total SNP heritability estimate was 4.19%. Genetic correlations with psychiatric disorders were most pronounced for major depressive disorder (MDD) and bipolar II disorder (BD II). MiXeR analysis revealed polygenic overlap with schizophrenia (SCZ), bipolar I disorder (BD I), and MDD. Conditional false discovery rate analyses identified additional loci associated with SCZ (number [n] of additional SNPs = 105), BD I (n = 54), MDD (n = 107), and irritability (n = 157). Conjunctional false discovery rate analyses identified 85, 41, and 198 shared loci between irritability and SCZ, BD I, and MDD, respectively. Multiple genetic loci were associated with irritability and three main psychiatric disorders. Given that irritability is a cross-disorder trait, these findings may help to elucidate the genomics of psychiatric disorders.